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    TACR1 tachykinin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 6869, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis.

    Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis.
    Al-Keilani MS, Almomani BA, Jaradat SA, Al-Sawalha NA, Qawasmeh MA.

    02/7/2024
    TNF-alpha evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

    TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.
    Gao X, Bayraktutan U.

    08/30/2023
    Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjogren's Syndrome (pSS) Pathogenesis.

    Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjögren's Syndrome (pSS) Pathogenesis.
    Rosso P, Fico E, Colafrancesco S, Bellizzi MG, Priori R, Cerbelli B, Leopizzi M, Giordano C, Greco A, Tirassa P, Severini C, Fusconi M., Free PMC Article

    07/10/2023
    The neuropeptide substance P/neurokinin-1 receptor system and diabetes: From mechanism to therapy.

    The neuropeptide substance P/neurokinin-1 receptor system and diabetes: From mechanism to therapy.
    Kokabi F, Ebrahimi S, Mirzavi F, Ghiasi Nooghabi N, Hashemi SF, Hashemy SI.

    06/8/2023
    Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis.

    Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis.
    Guan L, Yuan S, Ma J, Liu H, Huang L, Zhang F., Free PMC Article

    02/11/2023
    Upregulated expression of substance P and NK1R in blood monocytes and B cells of patients with allergic rhinitis and asthma.

    Upregulated expression of substance P and NK1R in blood monocytes and B cells of patients with allergic rhinitis and asthma.
    Han P, Chen L, Chen D, Yang R, Wang W, Liu J, He S, Zhang H., Free PMC Article

    10/29/2022
    Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-kappaB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.

    Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
    Li M, Zhong X, Xu WT., Free PMC Article

    10/15/2022
    The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma.

    The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma.
    Muñoz MF, Argüelles S, Rosso M, Medina R, Coveñas R, Ayala A, Muñoz M., Free PMC Article

    07/23/2022
    A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641.

    A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641.
    Ji T, Ma K, Wu H, Cao T., Free PMC Article

    05/28/2022
    The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors.

    The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors.
    Kolorz J, Demir S, Gottschlich A, Beirith I, Ilmer M, Lüthy D, Walz C, Dorostkar MM, Magg T, Hauck F, von Schweinitz D, Kobold S, Kappler R, Berger M., Free PMC Article

    04/2/2022
    Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR.

    Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR.
    Zhang XW, Li L, Hu WQ, Hu MN, Tao Y, Hu H, Miao XK, Yang WL, Zhu Q, Mou LY., Free PMC Article

    03/26/2022
    Prognostic Significance of Substance P/Neurokinin 1 Receptor and Its Association with Hormonal Receptors in Breast Carcinoma.

    Prognostic Significance of Substance P/Neurokinin 1 Receptor and Its Association with Hormonal Receptors in Breast Carcinoma.
    Mehboob R, Gilani SA, Hassan A, Sadaf, Tanvir I, Javaid S, Khalid S, Hasan S, Waseem H, Alwazzan A, Munoz M., Free PMC Article

    02/12/2022
    Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.

    Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
    Winning L, El Karim IA, Linden GJ, Irwin CR, Killough SA, Lundy FT.

    01/22/2022
    Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids.

    Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids.
    Feickert M, Burckhardt BB.

    12/4/2021
    Investigation of the Role of Neurokinin-1 Receptor Inhibition Using Aprepitant in the Apoptotic Cell Death through PI3K/Akt/NF-kappaB Signal Transduction Pathways in Colon Cancer Cells.

    Investigation of the Role of Neurokinin-1 Receptor Inhibition Using Aprepitant in the Apoptotic Cell Death through PI3K/Akt/NF-κB Signal Transduction Pathways in Colon Cancer Cells.
    Ghahremanloo A, Javid H, Afshari AR, Hashemy SI., Free PMC Article

    10/2/2021
    Neurokinin receptors in drug and alcohol addiction.

    Neurokinin receptors in drug and alcohol addiction.
    Schank JR., Free PMC Article

    07/31/2021
    New insight into the role of substance P/neurokinin-1 receptor system in breast cancer progression and its crosstalk with microRNAs.

    New insight into the role of substance P/neurokinin-1 receptor system in breast cancer progression and its crosstalk with microRNAs.
    Ebrahimi S, Javid H, Alaei A, Hashemy SI.

    07/3/2021
    Analysis of pharmacogenomic factors for chemotherapy-induced nausea and vomiting in patients with breast cancer receiving doxorubicin and cyclophosphamide chemotherapy.

    Analysis of pharmacogenomic factors for chemotherapy-induced nausea and vomiting in patients with breast cancer receiving doxorubicin and cyclophosphamide chemotherapy.
    Tsuji D, Matsumoto M, Kawasaki Y, Kim YL, Yamamoto K, Nakamichi H, Sahara Y, Makuta R, Yokoi M, Miyagi T, Itoh K.

    06/26/2021
    Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK1 and NK2 tachykinin receptors.

    Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.
    Dai L, Perera DS, Burcher E, Liu L.

    06/5/2021
    Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes.

    Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes.
    Pappa V, Spitsin S, Gaskill PJ, Douglas SD., Free PMC Article

    05/29/2021
    lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1.

    lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1.
    Hongfeng Z, Andong J, Liwen S, Mingping B, Xiaowei Y, Mingyong L, Aimin Y.

    05/1/2021
    SP/NK-1R promotes gallbladder cancer cell proliferation and migration.

    SP/NK-1R promotes gallbladder cancer cell proliferation and migration.
    Deng XT, Tang SM, Wu PY, Li QP, Ge XX, Xu BM, Wang HS, Miao L., Free PMC Article

    10/24/2020
    TGFbeta regulates NK1R-Tr to affect the proliferation and apoptosis of breast cancer cells.

    TGFβ regulates NK1R-Tr to affect the proliferation and apoptosis of breast cancer cells.
    Wang L, Wang N, Zhang R, Dong D, Liu R, Zhang L, Ji W, Yu M, Zhang F, Niu R, Zhou Y.

    09/5/2020
    The neuropeptide substance P regulates aldosterone secretion in human adrenals.

    The neuropeptide substance P regulates aldosterone secretion in human adrenals.
    Wils J, Duparc C, Cailleux AF, Lopez AG, Guiheneuf C, Boutelet I, Boyer HG, Dubessy C, Cherifi S, Cauliez B, Gobet F, Defortescu G, Ménard JF, Louiset E, Lefebvre H., Free PMC Article

    08/29/2020
    The significant role of NK1R in mediating ESCC cell proliferation depended on the activation of SP and might be related to the downstream regulation of Hes1.

    SP promotes cell proliferation in esophageal squamous cell carcinoma through the NK1R/Hes1 axis.
    Wang F, Liu S, Liu J, Feng F, Guo Y, Zhang W, Zheng G, Wang Q, Cai L, Guo M, Lian X, Xu G, Zhang H.

    07/25/2020
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