| Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice. | Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice.
Heida A, van Dijk T, Smit M, Koehorst M, Koster M, Kloosterhuis N, Havinga R, Bloks VW, Wolters JC, de Bruin A, Kuivenhoven JA, de Boer JF, Kuipers F, van de Sluis B. | 02/5/2024 |
| Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation. | Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.
Walpole GFW, Plumb JD, Chung D, Tang B, Boulay B, Osborne DG, Piotrowski JT, Catz SD, Billadeau DD, Grinstein S, Jaumouillé V., Free PMC Article | 05/8/2021 |
| The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance. | The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.
Wijers M, Zanoni P, Liv N, Vos DY, Jäckstein MY, Smit M, Wilbrink S, Wolters JC, van der Veen YT, Huijkman N, Dekker D, Kloosterhuis N, van Dijk TH, Billadeau DD, Kuipers F, Klumperman J, von Eckardstein A, Kuivenhoven JA, van de Sluis B., Free PMC Article | 09/19/2020 |
| WASH deficiency impairs the association of RNF2 with AMBRA1 to impede AMBRA1 degradation. | RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.
Xia P, Wang S, Huang G, Du Y, Zhu P, Li M, Fan Z., Free PMC Article | 04/4/2015 |
| WASH complex regulates Arp2/3 complex and is required for cytokinesis and polar body extrusion. | WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes.
Wang F, Zhang L, Zhang GL, Wang ZB, Cui XS, Kim NH, Sun SC., Free PMC Article | 02/28/2015 |
| WASH is required for the differentiation commitment of hematopoietic stem cells by acting as an upstream regulator to modulate c-Myc transcription. | WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, Du Y, Fan Z., Free PMC Article | 11/22/2014 |
| WASH can suppress Beclin 1 ubiquitination to inactivate Vps34 activity leading to suppression of autophagy. | WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.
Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z., Free PMC Article | 12/21/2013 |
| WASH is a newly recognized regulator of T cell receptor, CD28, LFA-1, and GLUT1 endosome-to-membrane recycling. | WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.
Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD., Free PMC Article | 04/13/2013 |
| WASH-mediated F-actin is requisite for the integrity of both endosomal and lysosomal networks in mammalian cells. | Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.
Gomez TS, Gorman JA, de Narvajas AA, Koenig AO, Billadeau DD., Free PMC Article | 12/29/2012 |
| WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells | Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
Monfregola J, Napolitano G, D'Urso M, Lappalainen P, Ursini MV., Free PMC Article | 05/11/2011 |
| show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes. | The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.
Derivery E, Sousa C, Gautier JJ, Lombard B, Loew D, Gautreau A. | 10/4/2010 |