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    TAP1 transporter 1, ATP binding cassette subfamily B member [ Homo sapiens (human) ]

    Gene ID: 6890, updated on 6-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of TAP1 1177A>G and 2090A>G gene polymorphisms with latent tuberculosis infections in sheltered populations, in the metropolitan area of Guadalajara, Mexico: a pilot study.

    Association of TAP1 1177A>G and 2090A>G gene polymorphisms with latent tuberculosis infections in sheltered populations, in the metropolitan area of Guadalajara, Mexico: a pilot study.
    Cazarez-Navarro G, Palomares-Marín J, Rodríguez-Preciado SY, Pereira-Suárez AL, Martínez-López E, Bacilio-Medrano EA, Huerta-Olvera S, Hernández-Cañaveral II., Free PMC Article

    08/28/2021
    Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population.

    Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population.
    Yang J, Liu W, Yan Z, Li C, Liu S, Yang X, Li Y, Shi L, Yao Y.

    07/24/2021
    Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production.

    Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production.
    Zhao J, Li R, Li Y, Chen J, Feng F, Sun C., Free PMC Article

    05/29/2021
    Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma.

    Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma.
    Zhou XT, Ding J, Li HY, Zuo JL, Ge SY, Jia HL, Wu J., Free PMC Article

    05/1/2021
    Associations of genetic variants at TAP1 and TAP2 with pulmonary tuberculosis risk among the Chinese population.

    Associations of genetic variants at TAP1 and TAP2 with pulmonary tuberculosis risk among the Chinese population.
    Zhang M, Wang X, Zhu Y, Chen S, Chen B, Liu Z., Free PMC Article

    04/24/2021
    Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival.

    Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival.
    Attaran N, Gu X, Coates PJ, Fåhraeus R, Boldrup L, Wilms T, Wang L, Sgaramella N, Zborayova K, Nylander K., Free PMC Article

    02/27/2021
    ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy.

    ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy.
    Nomura H, Tsuji D, Demachi K, Mochizuki N, Matsuzawa H, Yano T, Daiko H, Fujii S, Kojima T, Itoh K, Kawasaki T.

    02/20/2021
    Studied transporter 1 ATP binding cassette (TAP1) gene polymorphisms and human menstrual blood papillomavirus DNA as diagnostic/prognostic markers of Cervical Squamous Intraepithelial Lesion.

    Menstrual Blood Human Papillomavirus DNA and TAP1 Gene Polymorphisms as Potential Biomarkers for Screening and Monitoring of Cervical Squamous Intraepithelial Lesion.
    Wong SCC, Au TCC, Chan SCS, Ng LPW, Tsang HF.

    09/21/2019
    TAP polymorphisms have no or limited effect on peptide transport or MHC class I expression.

    The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.
    Praest P, Luteijn RD, Brak-Boer IGJ, Lanfermeijer J, Hoelen H, Ijgosse L, Costa AI, Gorham RD Jr, Lebbink RJ, Wiertz EJHJ.

    03/30/2019
    Our finding suggested that TAP1-rs1135216, TAP1-rs4148873, TAP2-rs2228396, TAP2-rs241447 and TAP2-rs4148873 might not be involved in cancer risk, but the T allele of TAP2-rs4148876 might be a potential biomarker for judging cancer risk [review, meta-analysis]

    An update meta-analysis and systematic review of TAP polymorphisms as potential biomarkers for judging cancer risk.
    Meng J, Li W, Zhang M, Hao Z, Fan S, Zhang L, Liang C.

    11/10/2018
    In a meta-analyses of 6 studies with 415 cases and 659 controls, a significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and ankylosing spondylitis compared with combined control group.

    Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis.
    Qian Y, Wang G, Xue F, Chen L, Wang Y, Tang L, Yang H.

    04/21/2018
    Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor

    Downregulation of TAP1 and TAP2 in early stage breast cancer.
    Henle AM, Nassar A, Puglisi-Knutson D, Youssef B, Knutson KL., Free PMC Article

    12/9/2017
    The structure shows that herpes simplex virus ICP47 traps human TAP in an inactive conformation distinct from the normal transport cycle.

    Structure of the transporter associated with antigen processing trapped by herpes simplex virus.
    Oldham ML, Grigorieff N, Chen J., Free PMC Article

    11/4/2017
    PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo.

    A case-control study on association of proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1) polymorphisms and their transcript levels in vitiligo from Gujarat.
    Jadeja SD, Mansuri MS, Singh M, Dwivedi M, Laddha NC, Begum R., Free PMC Article

    09/30/2017
    Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization.

    D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.
    Vakkasoglu AS, Srikant S, Gaudet R., Free PMC Article

    09/23/2017
    Significant associations between sorafenib exposure and the studied polymorphisms were observed for ABCB2

    Correlation between clinical response to sorafenib in hepatocellular carcinoma treatment and polymorphisms of P-glycoprotein (ABCB1) and of breast cancer resistance protein (ABCG2): monocentric study.
    Tandia M, Mhiri A, Paule B, Saffroy R, Cailliez V, Noé G, Farinotti R, Bonhomme-Faivre L.

    06/24/2017
    this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB signaling and the innate immune response by targeting the TAK1 complex

    Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
    Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y.

    05/6/2017
    there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients

    Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease.
    Mo MS, Huang W, Sun CC, Zhang LM, Cen L, Xiao YS, Li GF, Yang XL, Qu SG, Xu PY., Free PMC Article

    03/11/2017
    The disruption of TAP1 and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity.

    Generating hESCs with reduced immunogenicity by disrupting TAP1 or TAPBP.
    Cui D, Wang J, Zeng Y, Rao L, Chen H, Li W, Li Y, Li H, Cui C, Xiao L.

    01/28/2017
    TAP1/2 gene polymorphisms might be associated with pulmonary tuberculosis susceptibility among patients in Zahedan, southeast Iran.

    Association of TAP1 and TAP2 Gene Polymorphisms with Susceptibility to Pulmonary Tuberculosis.
    Naderi M, Hashemi M, Amininia S.

    01/28/2017
    The results suggest an association between a TAP1 promoter SNP (rs2071480) and susceptibility to alopecia areata in a Korean population.

    Association between TAP1 gene polymorphisms and alopecia areata in a Korean population.
    Kim HK, Lee H, Lew BL, Sim WY, Kim YO, Lee SW, Lee S, Cho IK, Kwon JT, Kim HJ.

    11/5/2016
    IFNalpha upregulates TAP1 expression in peripheral blood mononuclear cells (PBMCs) of patients with malignant melanoma receiving adjuvant high-dose immunotherapy.

    Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma.
    Heise R, Amann PM, Ensslen S, Marquardt Y, Czaja K, Joussen S, Beer D, Abele R, Plewnia G, Tampé R, Merk HF, Hermanns HM, Baron JM., Free PMC Article

    07/16/2016
    cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I

    A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.
    Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J., Free PMC Article

    02/13/2016
    this ultrasensitive method for the first time permits quantification of TAP activity under close to physiological conditions in scarce primary cell subsets such as antigen cross-presenting dendritic cells.

    Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.
    Fischbach H, Döring M, Nikles D, Lehnert E, Baldauf C, Kalinke U, Tampé R., Free PMC Article

    02/6/2016
    PSF1 expression correlates with a more aggressive phenotype as well as worse prognosis in hepatocellular carcinoma patients.

    Overexpression of PSF1 is correlated with poor prognosis in hepatocellular carcinoma patients.
    Zhou L, Sun XJ, Liu C, Wu QF, Tai MH, Wei JC, Lei L, Meng FD, Qu K, Xu J.

    11/28/2015
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