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    TBX3 T-box transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 6926, updated on 16-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TBX3 and TBX5 duplication: A family with an atypical overlapping Holt-Oram/ulnar-mammary syndrome phenotype.

    TBX3 and TBX5 duplication: A family with an atypical overlapping Holt-Oram/ulnar-mammary syndrome phenotype.
    Cenni C, Andres S, Hempel M, Strom TM, Thomas E, Davies A, Timoney N, Frigiola A, Logan M, Holder-Espinasse M.

    08/14/2021
    Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.

    Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
    Cai J, Drewry MD, Perkumas K, Dismuke WM, Hauser MA, Stamer WD, Liu Y., Free PMC Article

    07/3/2021
    USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57(KIP2) repression.

    USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57<sup>KIP2</sup> repression.
    Xie P, Wang H, Xie J, Huang Z, Chen S, Cheng X, Zhang X, Liu F, Li Y, Huang D.

    07/3/2021
    Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.

    Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
    van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott IC, Christoffels VM.,

    05/29/2021
    Transcription box3 protects human umbilical vein endothelial cells in a highglucose environment through sirtuin 1/AKT signaling.

    Transcription box‑3 protects human umbilical vein endothelial cells in a high‑glucose environment through sirtuin 1/AKT signaling.
    Yu Z, Zhang W, Zhang X, Xu D, Wang N., Free PMC Article

    04/17/2021
    Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells.

    Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells.
    Zhao H, Wang F, Zhang W, Yang M, Tang Y, Wang X, Zhao Q, Huang C.

    03/20/2021
    A de novo TBX3 mutation presenting as dorsalization of the little fingers: A forme fruste phenotype of ulnar-mammary syndrome.

    A de novo TBX3 mutation presenting as dorsalization of the little fingers: A forme fruste phenotype of ulnar-mammary syndrome.
    Al-Qattan MM, Maddirevula S, Alkuraya FS.

    10/3/2020
    Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.

    Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.
    Krstic M, Hassan HM, Kolendowski B, Hague MN, Anborgh PH, Postenka CO, Torchia J, Chambers AF, Tuck AB., Free PMC Article

    09/26/2020
    TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-beta1/Smad signaling.

    TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-β1/Smad signaling.
    Lee YJ, Park JH, Oh SM.

    08/22/2020
    Authors demonstrate that COL1A2 mediates the pro- and anti-migratory effects of TBX3 in chondrosarcoma and fibrosarcoma cells respectively. Data reveal that the AKT1/TBX3/COL1A2 axis plays an important role in sarcomagenesis.

    COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration.
    Omar R, Cooper A, Maranyane HM, Zerbini L, Prince S.

    06/13/2020
    TBX3 promotes progression of pre-invasive breast cancer cells in ductal carcinoma in situ by directly up-regulating SLUG expression and inducing epithelial mesenchymal transformation.

    TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG.
    Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMillan CD, Williams KC, Leong HS, Brackstone M, Torchia J, Chambers AF, Tuck AB., Free PMC Article

    04/18/2020
    The bioinformatic analysis identified TBX3 as a key regulator for the differentiation of cytotrophoblast into syncytiotrophoblast.

    Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses.
    Lv B, An Q, Zeng Q, Zhang X, Lu P, Wang Y, Zhu X, Ji Y, Fan G, Xue Z., Free PMC Article

    02/29/2020
    overexpression of TBX3 and HCN2 could reprogram human-induced pluripotent stem cells-derived cardiomyocytes into pacemaker-like cells

    <i>HCN2</i> and <i>TBX3</i> Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells.
    Zhao H, Wang F, Tang Y, Wang X, Wang T, Zhao Q, Huang C.

    02/22/2020
    Although TBX3 and TBX18 do not play a significant role in promoting the enrichment and differentiation of HiPS into sinoatrial node-like cells, TBX3 shows a certain promoting trend, which can be further explored in the future.

    [Role of over-expression of TBX3 and TBX18 in the enrichment and differentiation of human induced pluripotent stem cells into sinoatrial node-like cells].
    Liu F, Fang Y, Xiong Q, Luo L, Zhou R, Liao B., Free PMC Article

    08/10/2019
    Study demonstrates that TBX3 plays an essential role in papillary thyroid carcinoma (PTC) progression. TBX3 is able to promote cell proliferation and tumorigenesis of PTC possibly by facilitating the G1/S transition in the cell cycle.

    TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57<sup>KIP2</sup> repression.
    Li X, Ruan X, Zhang P, Yu Y, Gao M, Yuan S, Zhao Z, Yang J, Zhao L.

    03/2/2019
    High TBX3 expression is associated with Hepatocellular Carcinoma.

    T-box Transcription Factor Tbx3 Contributes to Human Hepatocellular Carcinoma Cell Migration and Invasion by Repressing E-Cadherin Expression.
    Feng X, Yao W, Zhang Z, Yuan F, Liang L, Zhou J, Liu S, Song J., Free PMC Article

    02/9/2019
    Our results indicate that the R608W and R616Q variants of TBX2 as well as the A192T and A562V variants of TBX3 contribute to Conotruncal heart defects (CTDs)etiology; this was the first association of variants of TBX2 and TBX3 to CTDs based on a large population.

    Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing.
    Xie H, Zhang E, Hong N, Fu Q, Li F, Chen S, Yu Y, Sun K., Free PMC Article

    02/2/2019
    TBX3 is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites.

    Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3.
    Colasanto MP, Eyal S, Mohassel P, Bamshad M, Bonnemann CG, Zelzer E, Moon AM, Kardon G., Free PMC Article

    12/9/2017
    High TBX3 expression is associated with invasive breast cancer.

    The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer.
    Krstic M, Macmillan CD, Leong HS, Clifford AG, Souter LH, Dales DW, Postenka CO, Chambers AF, Tuck AB., Free PMC Article

    09/30/2017
    genetic variation of Tbx3 is associated with left ventricular mass in a healthy Japanese population [meta-analysis]

    Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population.
    Sano M, Kamitsuji S, Kamatani N, Tabara Y, Kawaguchi T, Matsuda F, Yamagishi H, Fukuda K, Japan Pharmacogenomics Data Science Consortium (JPDSC).., Free PMC Article

    07/22/2017
    Study demonstrates that miR-206 directly targets Tbx3, that miR-206 and Tbx3 mRNA are inversely correlated in human breast cancer and that Tbx3 repression is necessary to elicit a significant functional effect of miR-206 in breast cancer cells.

    Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer.
    Amir S, Simion C, Umeh-Garcia M, Krig S, Moss T, Carraway KL 3rd, Sweeney C., Free PMC Article

    06/3/2017
    The c.1423C>T (p.Q475*) nonsense mutation in exon 6 of the TBX3 gene associated with ulnar-mammary syndrome.

    Novel TBX3 mutation in a family of Cypriot ancestry with ulnar-mammary syndrome.
    Tanteles GA, Nicolaou N, Syrimis A, Metaxa R, Nicolaou M, Christophidou-Anastasiadou V, Skordis N.

    03/18/2017
    Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples

    Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion.
    Miao ZF, Liu XY, Xu HM, Wang ZN, Zhao TT, Song YX, Xing YN, Huang JY, Zhang JY, Xu H, Xu YY.

    02/18/2017
    These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 and TBX5, and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1

    Novel copy number variants and major limb reduction malformation: Report of three cases.
    Shamseldin HE, Anazi S, Wakil SM, Faqeih E, El Khashab HY, Salih MA, Al-Qattan MM, Hashem M, Alsedairy H, Alkuraya FS.

    01/14/2017
    this new molecular-grade based on the combination of TBX2 and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.

    Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer.
    Beukers W, Kandimalla R, Masius RG, Vermeij M, Kranse R, van Leenders GJ, Zwarthoff EC.

    03/26/2016
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