| TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-gamma-mediated ferroptosis. | TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-γ-mediated ferroptosis.
Yang Y, Ma Y, Yu S, Lin Z, Yan C, Wang Y, Yuan Q, Meng Z, Yan G, Wu Z, Tang H, Peng Z, Huang J, Zhuang G. | 11/29/2022 |
| TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice. | TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
Xia X, Wang S, Wu L, Li G, Hou K, Yu A, Yang Z. | 11/19/2022 |
| Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
Yao R, Kong L, Yang C, Du J, Zhao G, Li Y., Free PMC Article | 05/14/2022 |
| TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer. | TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
Etwebi Z, Goldsmith JR, Bou-Dargham M, Tian Y, Hood R, Spitofsky N, Li M, Sun H, Lou Y, Liu S, Lengner C, Chen YH., Free PMC Article | 05/14/2022 |
| Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
Lou Y, Song M, Han M, Zhong J, Tian X, Ren Y, Song Y, Duan L, Zhao P, Song X, Zhang W, Chen YH, Wang H. | 05/7/2022 |
| TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity. | TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
Bi J, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H., Free PMC Article | 04/16/2022 |
| TNF-alpha-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice. | TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
Liu SQ, Ren C, Yao RQ, Wu Y, Luan YY, Dong N, Yao YM., Free PMC Article | 02/5/2022 |
| TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway. | TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
Wang H, Zhong B, Geng Y, Hao J, Jin Q, Zhang Y, Dong L, Gao D, Li J, Hou W., Free PMC Article | 01/29/2022 |
| Tumor Necrosis Factor alpha-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation. | Tumor Necrosis Factor α-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
Liu Y, Song J, Yang J, Zheng J, Yang L, Gao J, Tian S, Liu Z, Meng X, Wang JC, Dai Z, Tang YD. | 01/15/2022 |
| Tumor necrosis factor alphainduced protein 8like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharideinduced acute lung injury in a mouse model. | Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model.
Yuan M, Jing G, Kong Q, Ming T, Song X, Wu X. | 01/8/2022 |
| TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis. | TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L., Free PMC Article | 01/1/2022 |
| Up-regulating TIPE2 alleviates inflammatory pain by suppressing microglial activation-mediated inflammatory response via inhibiting Rac1/NF-kappaB pathway. | Up-regulating TIPE2 alleviates inflammatory pain by suppressing microglial activation-mediated inflammatory response via inhibiting Rac1/NF-κB pathway.
Sun X, Li X, Zhou Y, Wang Y, Liu X. | 10/2/2021 |
| mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice. | mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice.
Xu Z, Lu W, Miao Y, Li H, Xie X, Zhang F. | 05/29/2021 |
| Microarray gene expression profiling provides insights into functions of TIPE2 in HBV-related apoptosis. | Microarray gene expression profiling provides insights into functions of TIPE2 in HBV-related apoptosis.
Cui J, Zhang N, Liu Y, Zhang L, Gao C, Liu S. | 04/3/2021 |
| Protective Effect of Dexmedetomidine on Acute Lung Injury via the Upregulation of Tumour Necrosis Factor-alpha-Induced Protein-8-like 2 in Septic Mice. | Protective Effect of Dexmedetomidine on Acute Lung Injury via the Upregulation of Tumour Necrosis Factor-α-Induced Protein-8-like 2 in Septic Mice.
Kong Q, Wu X, Qiu Z, Huang Q, Xia Z, Song X., Free PMC Article | 04/3/2021 |
| The SCF(beta-TrCP) E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2. | The SCF(β-TrCP) E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2.
Lou Y, Han M, Song Y, Zhong J, Zhang W, Chen YH, Wang H. | 01/2/2021 |
| Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation. | Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation.
Zhou J, Chen P, Li Z, Zuo Q. | 12/12/2020 |
| Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases. | Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases.
Liu R, He X, Geng W, Wang T, Ruan Q., Free PMC Article | 10/31/2020 |
| Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice. | Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.
Miao Y, Wang N, Shao W, Xu Z, Yang Z, Wang L, Ju C, Zhang R, Zhang F. | 09/19/2020 |
| TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. | TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X., Free PMC Article | 09/12/2020 |
| TIPE2 promoted host resistance to Pseudomonas aeruginosa Keratitis by suppressing corneal inflammation via regulating TAK1 signaling negatively and inhibiting the infiltration of inflammatory cells. | TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.
Wang Q, Ma L, Liu T, Ge C, Zhou Q, Wei C, Shi W. | 05/23/2020 |
| Our study shows that the increased expression of AAV-mediated TIPE2 in the lungs of mice inhibits acute inflammation and apoptosis and suppresses the activation of NF-kappaB and JNK in a murine model of acute lung injury (ALI). Our results indicate that TIPE2 might be useful as a potential therapeutic target for sepsis-induced ALI. | TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury.
Wu X, Kong Q, Zhan L, Qiu Z, Huang Q, Song X., Free PMC Article | 03/21/2020 |
| Downregulation of TIPE2 in vivo can reduce the apoptosis of CD4 T lymphocytes following thermal damage, and activate the TGFss downstream signaling of Smad2/Smad3, upregulating Bim, and downregulating Bcl-2. | Tumor Necrosis Factor-α-Induced Protein 8-like 2 Downregulation Reduces CD4⁺ T Lymphocyte Apoptosis in Mice with Thermal Injury.
Huang H, Cui Y, Tian Z, Li T, Yao Y., Free PMC Article | 03/14/2020 |
| our results indicate that a reduction of TIPE2 expression is observed in dystrophic skeletal muscle, when compared to WT and more importantly that TIPE2 gene delivery may provide as a novel anti-inflammatory therapy to alleviate the muscle weakness in DMD patients. | TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.
Gao S, Lu A, Amra S, Guo P, Huard J. | 02/8/2020 |
| TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells. | Egress of murine regulatory T cells from the thymus requires TIPE2.
Fan T, Huang X, Liu C, Liu R, Wang T, Ruan Q. | 09/22/2018 |