| Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFalpha-mediated osteoclastogenesis. | Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFα-mediated osteoclastogenesis.
Yoshida S, Ikedo A, Yanagihara Y, Sakaue T, Saeki N, Imai Y. | 04/30/2024 |
| Expression of the checkpoint kinase BUB1 is a predictor of response to cancer therapies. | Expression of the checkpoint kinase BUB1 is a predictor of response to cancer therapies.
Cicirò Y, Ragusa D, Sala A., Free PMC Article | 03/8/2024 |
| The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma. | The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma.
Cicirò Y, Ragusa D, Nevado PT, Lattanzio R, Sala G, DesRochers T, Millard M, Andersson MK, Stenman G, Sala A. | 02/5/2024 |
| Knockdown of BUB1 inhibits tumor necrosis factor-alpha-induced proliferation and migration of rheumatoid arthritis synovial fibroblasts by regulating PI3K/Akt pathway. | Knockdown of BUB1 inhibits tumor necrosis factor-α-induced proliferation and migration of rheumatoid arthritis synovial fibroblasts by regulating PI3K/Akt pathway.
He Q, Jia L, Wang X, Feng D, Mao T. | 10/11/2023 |
| BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling. | BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling.
Banerjee A, Chen C, Humphrey L, Tyson JJ, Joglekar AP., Free PMC Article | 08/27/2022 |
| BUB1 predicts poor prognosis and immune status in liver hepatocellular carcinoma. | BUB1 predicts poor prognosis and immune status in liver hepatocellular carcinoma.
Qi W, Bai Y, Wang Y, Liu L, Zhang Y, Yu Y, Chen H. | 07/9/2022 |
| BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer. | BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.
Wang S, Liu X, Yang M, Yuan D, Ye K, Qu X, Wang X., Free PMC Article | 05/14/2022 |
| Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation. | Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.
Carvalhal S, Bader I, Rooimans MA, Oostra AB, Balk JA, Feichtinger RG, Beichler C, Speicher MR, van Hagen JM, Waisfisz Q, van Haelst M, Bruijn M, Tavares A, Mayr JA, Wolthuis RMF, Oliveira RA, de Lange J., Free PMC Article | 04/30/2022 |
| Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation. | Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation.
Chen Q, Zhang M, Pan X, Yuan X, Zhou L, Yan L, Zeng LH, Xu J, Yang B, Zhang L, Huang J, Lu W, Fukagawa T, Wang F, Yan H. | 02/19/2022 |
| Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways. | Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways.
Huang Z, Wang S, Wei H, Chen H, Shen R, Lin R, Wang X, Lan W, Lin R, Lin J., Free PMC Article | 02/19/2022 |
| Prognostic Value of BUB1 for Predicting Non-Muscle-Invasive Bladder Cancer Progression. | Prognostic Value of BUB1 for Predicting Non-Muscle-Invasive Bladder Cancer Progression.
Piao XM, You C, Byun YJ, Kang HW, Noh J, Lee J, Lee HY, Kim K, Kim WT, Yun SJ, Lee SC, Kang K, Kim YJ., Free PMC Article | 12/18/2021 |
| KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression. | KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression.
Jin W, Ye L., Free PMC Article | 11/13/2021 |
| Weighted genes associated with the progression of retinoblastoma: Evidence from bioinformatic analysis. | Weighted genes associated with the progression of retinoblastoma: Evidence from bioinformatic analysis.
Zhou W, Guan W, Zhou Y, Rao Y, Ji X, Li J. | 11/6/2021 |
| Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways. | Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways.
Nguyen AL, Fadel MD, Cheeseman IM., Free PMC Article | 09/18/2021 |
| Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma. | Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma.
Long Z, Wu T, Tian Q, Carlson LA, Wang W, Wu G., Free PMC Article | 07/31/2021 |
| BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis. | BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis.
Singh P, Pesenti ME, Maffini S, Carmignani S, Hedtfeld M, Petrovic A, Srinivasamani A, Bange T, Musacchio A., Free PMC Article | 02/2/2021 |
| SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres. | SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres.
Asai Y, Matsumura R, Hasumi Y, Susumu H, Nagata K, Watanabe Y, Terada Y., Free PMC Article | 12/26/2020 |
| Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis. | Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis.
Hadders MA, Hindriksen S, Truong MA, Mhaskar AN, Wopken JP, Vromans MJM, Lens SMA., Free PMC Article | 10/24/2020 |
| Histone H2A phosphorylation recruits topoisomerase IIalpha to centromeres to safeguard genomic stability. | Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability.
Zhang M, Liang C, Chen Q, Yan H, Xu J, Zhao H, Yuan X, Liu J, Lin S, Lu W, Wang F., Free PMC Article | 08/13/2020 |
| Here, we present for the first time the identification and the preclinical profile of the novel BUB1 kinase inhibitor BAY 1816032. In particular, we demonstrate additive and more than additive efficacy upon combination of BUB1 kinase inhibition with taxanes, as well as with PARP inhibitors in cellular and in tumor xenograft models. | Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo.
Siemeister G, Mengel A, Fernández-Montalván AE, Bone W, Schröder J, Zitzmann-Kolbe S, Briem H, Prechtl S, Holton SJ, Mönning U, von Ahsen O, Johanssen S, Cleve A, Pütter V, Hitchcock M, von Nussbaum F, Brands M, Ziegelbauer K, Mumberg D. | 04/25/2020 |
| KNL1 protein expression was also significantly associated with poorer survival. Moreover, there was a significant correlation between KNL1 and BUB1 in colorectal cancer tissues. KNL1 plays an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach in patients with colorectal cancer. | Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells.
Bai T, Zhao Y, Liu Y, Cai B, Dong N, Li B., Free PMC Article | 01/11/2020 |
| Wwhile Bub1 is required for recruitment of BubR1, it is not strictly required for the checkpoint response to unattached kinetochores in diploid human cells. | Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells.
Currie CE, Mora-Santos M, Smith CA, McAinsh AD, Millar JBA. | 10/19/2019 |
| study demonstrated that CDK1 and BUB1 may play a role in Pancreatic ductal adenocarcinoma (PDAC) progression and could be prognostic biomarkers for PDAC patients. | High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma.
Piao J, Zhu L, Sun J, Li N, Dong B, Yang Y, Chen L. | 05/4/2019 |
| The roles for the BUB3-BUB1 complex in S phase. | The BUB3-BUB1 Complex Promotes Telomere DNA Replication.
Li F, Kim H, Ji Z, Zhang T, Chen B, Ge Y, Hu Y, Feng X, Han X, Xu H, Zhang Y, Yu H, Liu D, Ma W, Songyang Z., Free PMC Article | 01/26/2019 |
| Conserved domain 1 (CD1) in human Bub1 binds directly to Mad1 and a phosphorylation site exists in CD1 that stimulates Mad1 binding and SAC signalling. | Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling.
Zhang G, Kruse T, López-Méndez B, Sylvestersen KB, Garvanska DH, Schopper S, Nielsen ML, Nilsson J., Free PMC Article | 11/24/2018 |