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    TFAP2A transcription factor AP-2 alpha [ Homo sapiens (human) ]

    Gene ID: 7020, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2.

    Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2.
    Cano I, Wild M, Gupta U, Chaudhary S, Ng YSE, Saint-Geniez M, D'Amore PA, Hu Z., Free PMC Article

    04/29/2024
    Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer.

    Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer.
    Zou H, Luo J, Guo Y, Deng L, Zeng L, Pan Y, Li P.

    03/11/2024
    Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer.

    Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer.
    Niu C, Wen H, Wang S, Shu G, Wang M, Yi H, Guo K, Pan Q, Yin G., Free PMC Article

    03/6/2024
    TFAP2A activates HMGA1 to promote glycolysis and lung adenocarcinoma progression.

    TFAP2A activates HMGA1 to promote glycolysis and lung adenocarcinoma progression.
    Zhao J, Lan G.

    09/12/2023
    Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.

    Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
    Liu K, Xiao Y, Gan L, Li W, Zhang J, Min J., Free PMC Article

    08/28/2023
    Epigenetically modified AP-2alpha by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression.

    Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression.
    Long S, Huang G, Ouyang M, Xiao K, Zhou H, Hou A, Li Z, Zhong Z, Zhong D, Wang Q, Xiang S, Ding X., Free PMC Article

    06/22/2023
    TFAP2A promotes cervical cancer via a positive feedback pathway with PD-L1.

    TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1.
    Yang J, Gao Y, Yao S, Wan S, Cai H., Free PMC Article

    04/26/2023
    Transcription factor AP-2alpha activates RNA polymerase III-directed transcription and tumor cell proliferation by controlling expression of c-MYC and p53.

    Transcription factor AP-2α activates RNA polymerase III-directed transcription and tumor cell proliferation by controlling expression of c-MYC and p53.
    Wang J, Chen Q, Peng F, Zhao S, Zhang C, Song X, Yu D, Wu Z, Du J, Ni H, Deng H, Deng W., Free PMC Article

    04/4/2023
    AP2a-Mediated Upregulation of miR-125a-5p Ameliorates Radiation-Induced Oxidative Stress Injury via BRD4/Nrf2/HO-1 Signaling.

    AP2a-Mediated Upregulation of miR-125a-5p Ameliorates Radiation-Induced Oxidative Stress Injury via BRD4/Nrf2/HO-1 Signaling.
    Qiu J, Fang Y, Xiao S, Zeng F.

    02/28/2023
    The oncogenic role of TFAP2A in bladder urothelial carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis.

    The oncogenic role of TFAP2A in bladder urothelial carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis.
    He J, Dong C, Zhang H, Jiang Y, Liu T, Man X.

    01/7/2023
    Long noncoding RNA CDKN2B-AS1 silencing protects against esophageal cancer cell invasion and migration by inactivating the TFAP2A/FSCN1 axis.

    Long noncoding RNA CDKN2B-AS1 silencing protects against esophageal cancer cell invasion and migration by inactivating the TFAP2A/FSCN1 axis.
    Zhu JL, Xue WB, Jiang ZB, Feng W, Liu YC, Nie XY, Jin LY.

    12/24/2022
    Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression.

    Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression.
    Sun T, Zhang K, Li W, Liu Y, Pangeni RP, Li A, Arvanitis L, Raz DJ., Free PMC Article

    10/1/2022
    Family based and case-control designs reveal an association of TFAP2A in nonsyndromic cleft lip only among Vietnamese population.

    Family based and case-control designs reveal an association of TFAP2A in nonsyndromic cleft lip only among Vietnamese population.
    Nguyen DM, Suzuki S, Imura H, Niimi T, Furukawa H, Ta TV, Tong SM, Nguyen TT, Pham LNG, Tran DL, Natsume N., Free PMC Article

    03/19/2022
    AP-2alpha Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer.

    AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer.
    Beck AC, Cho E, White JR, Paemka L, Li T, Gu VW, Thompson DT, Koch KE, Franke C, Gosse M, Wu VT, Landers SR, Pamatmat AJ, Kulak MV, Weigel RJ., Free PMC Article

    01/29/2022
    Polymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population.

    Polymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population.
    Tsai DJ, Tai MC, Kao CC, Chen WT, Wu LW, Chiu CC, Tu MY, Chen YC, Wu CC, Su SL.

    01/15/2022
    AP-2alpha-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis.

    AP-2α-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis.
    White JR, Thompson DT, Koch KE, Kiriazov BS, Beck AC, van der Heide DM, Grimm BG, Kulak MV, Weigel RJ., Free PMC Article

    01/8/2022
    A positive feedback loop between Periostin and TGFbeta1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2alpha activation.

    A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation.
    Chen G, Wang Y, Zhao X, Xie XZ, Zhao JG, Deng T, Chen ZY, Chen HB, Tong YF, Yang Z, Ding XW, Guo PY, Yu HT, Wu LJ, Zhang SN, Zhu QD, Li JJ, Shan YF, Yu FX, Yu ZP, Xia JL., Free PMC Article

    01/8/2022
    TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation.

    TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation.
    Cui Y, Zhang C, Ma S, Guan F.

    11/13/2021
    TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-beta signaling pathway.

    TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-β signaling pathway.
    Xiong Y, Feng Y, Zhao J, Lei J, Qiao T, Zhou Y, Lu Q, Jiang T, Jia L, Han Y., Free PMC Article

    09/25/2021
    Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI.

    Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI.
    Cao Q, Feng D, He J, Zhou L, Fan Z, Chen Y, Chen X, Jin R, Zhou G.

    09/11/2021
    Silencing of lncRNA DLEU1 inhibits tumorigenesis of ovarian cancer via regulating miR-429/TFAP2A axis.

    Silencing of lncRNA DLEU1 inhibits tumorigenesis of ovarian cancer via regulating miR-429/TFAP2A axis.
    Xu H, Wang L, Jiang X.

    07/17/2021
    Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.

    Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.
    Cheng C, Ai Z, Zhao L.

    07/3/2021
    Functional genomics of AP-2alpha and AP-2gamma in cancers: in silico study.

    Functional genomics of AP-2α and AP-2γ in cancers: in silico study.
    Kołat D, Kałuzińska Ż, Orzechowska M, Bednarek AK, Płuciennik E., Free PMC Article

    05/8/2021
    KCTD1 mutants in scalpearnipple syndrome and AP2alpha P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/betacatenin signaling.

    KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling.
    Hu L, Chen L, Yang L, Ye Z, Huang W, Li X, Liu Q, Qiu J, Ding X., Free PMC Article

    05/8/2021
    TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis.

    TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis.
    Huang HX, Yang G, Yang Y, Yan J, Tang XY, Pan Q.

    04/24/2021
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