| Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse. | Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Park JS, Heo H, Kim MS, Lee SE, Park S, Kim KH, Kang YH, Kim JS, Sung YH, Shim WH, Kim DH, Song Y, Yoon SY., Free PMC Article | 03/12/2024 |
| CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders. | CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders.
Yoo H, Lee HR, Kim KH, Kim MA, Bang S, Kang YH, Kim WH, Song Y, Chang SE., Free PMC Article | 02/12/2022 |
| The results demonstrate that the localization of CRTC3 involves in regulating cold-induced upregulation of UCP1 in BAT and provide useful information for understanding the molecular regulation of BAT thermogenesis induced by a cold environment. | Cold exposure induces nuclear translocation of CRTC3 in brown adipose tissue.
Xu Z, Liu J, You W, Wang Y, Shan T. | 07/25/2020 |
| CRTC3 reduced sympathetic nerve activity in BAT by up-regulating the expression of miR-206, a microRNA that promotes differentiation along the myogenic lineage and that we show here decreases the expression of VEGFA and neurotrophins critical for BAT innervation and vascularization. | cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis.
Yoon YS, Tsai WW, Van de Velde S, Chen Z, Lee KF, Morgan DA, Rahmouni K, Matsumura S, Wiater E, Song Y, Montminy M., Free PMC Article | 09/8/2018 |
| Deletion of Lkb1 results in a cytoplasm to nuclear translocation of CRTC3 in brown adipocytes, where it recruits C/EBPbeta to enhance Ucp1 transcription. | Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.
Shan T, Xiong Y, Zhang P, Li Z, Jiang Q, Bi P, Yue F, Yang G, Wang Y, Liu X, Kuang S., Free PMC Article | 09/1/2018 |
| These results demonstrate how cross-coupling between the CREB/CRTC and JAK/STAT pathways contributes to bone marrow homeostasis. | CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.
Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M., Free PMC Article | 06/23/2018 |
| the existence of an unusual functional interplay between STATs and CREB at the onset of adipogenesis through shared CRTC cofactors, is reported. | MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.
Hallenborg P, Siersbæk M, Barrio-Hernandez I, Nielsen R, Kristiansen K, Mandrup S, Grøntved L, Blagoev B., Free PMC Article | 10/14/2017 |
| Three mouse CRTCs (Crtc1, Crtc2 and Crtc3) exhibit distinct patterns of 14-3-3 binding at three conserved sites corresponding to S70, S171, and S275 (in CRTC2). | Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.
Sonntag T, Moresco JJ, Vaughan JM, Matsumura S, Yates JR 3rd, Montminy M., Free PMC Article | 08/26/2017 |
| beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3. | Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.
Bruno NE, Kelly KA, Hawkins R, Bramah-Lawani M, Amelio AL, Nwachukwu JC, Nettles KW, Conkright MD., Free PMC Article | 08/9/2014 |
| CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone | Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.
Than TA, Lou H, Ji C, Win S, Kaplowitz N., Free PMC Article | 09/3/2011 |
| the cAMP response element binding (CREB) coactivator Crtc3 promotes obesity by attenuating beta-adrenergic receptor signalling in adipose tissue | CRTC3 links catecholamine signalling to energy balance.
Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, CHARGE Consortium, GIANT Consortium, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M., Free PMC Article | 02/26/2011 |