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    TLR4 toll like receptor 4 [ Homo sapiens (human) ]

    Gene ID: 7099, updated on 12-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.

    Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.
    Mattke J, Darden CM, Lawrence MC, Kuncha J, Shah YA, Kane RR, Naziruddin B., Free PMC Article

    04/12/2024
    Toll-like receptor-4 expression and oxidative stress in ocular rosacea.

    Toll-like receptor-4 expression and oxidative stress in ocular rosacea.
    Yesilirmak N, Bukan N, Kurt B, Fatsa T, Yuzbasıoglu S, Zhao M, Hosbul T, Bourges JL, Behar-Cohen F., Free PMC Article

    04/12/2024
    Impact of toll-like receptor 4 variations on nasopharyngeal carcinoma risk and survival in tunisian population.

    Impact of toll-like receptor 4 variations on nasopharyngeal carcinoma risk and survival in tunisian population.
    Ben Chaaben A, Ayadi I, Abaza H, Baroudi O, Douik H, Harzallah L, Bouassida J, Bouckouaci W, Guemira F, Mankai A, Kharrat M, Tamouza R.

    04/8/2024
    TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.

    TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.
    Jiang C, Huang Y, Gui H, Liu X, Li H, Han M, Huang S.

    04/4/2024
    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.

    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.
    Ayari F, Chaaben AB, Abaza H, Mihoub O, Ouni N, Boukouaci W, Kharrat M, Leboyer M, Guemira F, Tamouza R, Mankai A.

    04/4/2024
    TNF-alpha promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis.

    TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis.
    Cui H, Li J, Li X, Su T, Wen P, Wang C, Deng X, Fu Y, Zhao W, Li C, Hua P, Zhu Y, Wan W.

    04/2/2024
    Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-kappaB pathway.

    Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-κB pathway.
    Liu J, Zhang X, Yu Z, Zhang T.

    03/25/2024
    [miR-515-5p targeting Toll-like receptor 4 regulates myeloid differentiation primary response gene 88/nuclear factor-kappa B pathway to inhibit apoptosis and inflammatory response of osteoarthritis chondrocytes].

    [miR-515-5p targeting Toll-like receptor 4 regulates myeloid differentiation primary response gene 88/nuclear factor-kappa B pathway to inhibit apoptosis and inflammatory response of osteoarthritis chondrocytes].
    Cai D, Yang Z, Zhong C, Zhang J, Hong S., Free PMC Article

    03/20/2024
    Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.

    Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.
    Rasi V, Phelps KR, Paulson KR, Eickhoff CS, Chinnaraj M, Pozzi N, Di Gioia M, Zanoni I, Shakya S, Carlson HL, Ford DA, Kolar GR, Hoft DF.,

    03/18/2024
    The association of TLR4 gene polymorphisms with the severity of peritonitis in acute inflammatory diseases of the abdominal cavity organs.

    The association of TLR4 gene polymorphisms with the severity of peritonitis in acute inflammatory diseases of the abdominal cavity organs.
    Bilyayeva O, Kryzhevsky V, Karol I, Ziablitzev S.

    03/11/2024
    The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19).

    The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19).
    Zacher C, Schönfelder K, Rohn H, Siffert W, Möhlendick B., Free PMC Article

    03/6/2024
    Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.

    Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.
    Gao JH, He AD, Liu LM, Zhou YJ, Guo YW, Lu M, Zeng XB, Gong X, Lu YJ, Liang HF, Zhang BX, Ma R, Zhang RY, Ming ZY.

    03/5/2024
    Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147.

    Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147.
    Habeichi NJ, Amin G, Lakkis B, Kataya R, Mericskay M, Booz GW, Zouein FA., Free PMC Article

    03/1/2024
    TLR4, IgA and EpCAM Expression in Colorectal Cancer and Their Possible Association with Microbiota as a Pathogenic Factor; An Immunohistochemical and Genetic Study.

    TLR4, IgA and EpCAM Expression in Colorectal Cancer and Their Possible Association with Microbiota as a Pathogenic Factor; An Immunohistochemical and Genetic Study.
    Hafez FS, Shakweer MM, Sabry D, Tawfik AM, El-Beah SM, Elsheshtawy NM, Shash LS, Salama DEA, Gaballah A.

    02/29/2024
    LPS-TLR4 pathway exaggerates alcoholic hepatitis via provoking NETs formation.

    LPS-TLR4 pathway exaggerates alcoholic hepatitis via provoking NETs formation.
    Liu Y, Chen S, Yu S, Wang J, Zhang X, Lv H, Aboubacar H, Gao N, Ran X, Sun Y, Cao G.

    02/21/2024
    Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent.

    Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent.
    Khomula EV, Araldi D, Green PG, Levine JD., Free PMC Article

    02/20/2024
    P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer.

    P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer.
    Bates M, Mullen D, Lee E, Costigan D, Heron EA, Kernan N, Barry-O'Crowley J, Martin C, Keegan H, Malone V, Brooks RD, Brooks DA, Logan JM, Martini C, Selemidis S, McFadden J, O'Riain C, Spillane CD, Gallagher MF, McCann A, O'Toole S, O'Leary JJ.

    02/16/2024
    Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.

    Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
    Budzyń M, Gryszczyńska B, Begier-Krasińska B, Kaja E, Mikołajczak P, Kujawski R, Grupińska J, Iskra M, Tykarski A, Kaczmarek M.

    02/8/2024
    Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19.

    Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19.
    Flores-Gonzalez J, Chavez-Galan L, Falfán-Valencia R, Roldán IB, Fricke-Galindo I, Veronica-Aguilar A, Martínez-Morales A, Hernández-Zenteno RJ, Guzmán-Guzmán IP, Pérez-Rubio G.

    01/31/2024
    Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.

    Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.
    Hopp MT, Holze J, Lauber F, Holtkamp L, Rathod DC, Miteva MA, Prestes EB, Geyer M, Manoury B, Merle NS, Roumenina LT, Bozza MT, Weindl G, Imhof D.

    01/30/2024
    Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.

    Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.
    Jie J, Wu T., Free PMC Article

    01/29/2024
    Taenia solium excretory secretory proteins (ESPs) suppresses TLR4/AKT mediated ROS formation in human macrophages via hsa-miR-125.

    Taenia solium excretory secretory proteins (ESPs) suppresses TLR4/AKT mediated ROS formation in human macrophages via hsa-miR-125.
    Arora N, Keshri AK, Kaur R, Rawat SS, Kumar R, Mishra A, Prasad A., Free PMC Article

    01/16/2024
    Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.

    Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
    Chu C, Wang X, Chen F, Yang C, Shi L, Xu W, Wang K, Liu B, Wang C, Sun D, Li J, Ding W., Free PMC Article

    01/9/2024
    The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors.

    The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors.
    Fan W, Xu H, Chen F, Li X.

    01/4/2024
    Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments.

    Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments.
    Ducharme JB, McKenna ZJ, Specht JW, Fennel ZJ, Berkemeier QN, Deyhle MR.

    01/3/2024
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