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    TNNT2 troponin T2, cardiac type [ Homo sapiens (human) ]

    Gene ID: 7139, updated on 21-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.

    Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
    Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, Chase PB, Pinto JR., Free PMC Article

    08/25/2023
    De Novo Asp219Val Mutation in Cardiac Tropomyosin Associated with Hypertrophic Cardiomyopathy.

    De Novo Asp219Val Mutation in Cardiac Tropomyosin Associated with Hypertrophic Cardiomyopathy.
    Tsaturyan AK, Zaklyazminskaya EV, Polyak ME, Kopylova GV, Shchepkin DV, Kochurova AM, Gonchar AD, Kleymenov SY, Koubasova NA, Bershitsky SY, Matyushenko AM, Levitsky DI., Free PMC Article

    01/21/2023
    Cardiac troponin T as a postmortem biomarker for acute myocardial infarction.

    Cardiac troponin T as a postmortem biomarker for acute myocardial infarction.
    Moridi M, Magnusson C, Zilg B.

    12/10/2022
    Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.

    Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.
    Eggers KM, Hammarsten O, Aldous SJ, Cullen L, Greenslade JH, Lindahl B, Parsonage WA, Pemberton CJ, Pickering JW, Richards AM, Troughton RW, Than MP., Free PMC Article

    11/5/2022
    Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results.

    Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results.
    Ferencik M, Mayrhofer T, Lu MT, Bittner DO, Emami H, Puchner SB, Meyersohn NM, Ivanov AV, Adami EC, Voora D, Ginsburg GS, Januzzi JL, Douglas PS, Hoffmann U., Free PMC Article

    08/13/2022
    Allele-specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T.

    Allele-specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T.
    Migliore L, Galvagni F, Pierantozzi E, Sorrentino V, Rossi D., Free PMC Article

    06/11/2022
    High-Sensitivity Cardiac Troponin T, Age, and Outcome in Non-ST-Elevation Myocardial Infarction.

    High-Sensitivity Cardiac Troponin T, Age, and Outcome in Non-ST-Elevation Myocardial Infarction.
    Eggers KM, Lindahl B.

    04/30/2022
    Evaluation of Cardiac Troponin and Adverse Outcomes After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.

    Evaluation of Cardiac Troponin and Adverse Outcomes After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.
    Memar Montazerin S, Chi G, Marandi R, Najafi H, Shojaei F, Lee JJ, Marszalek J, Seifi A.

    04/30/2022
    Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy.

    Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy.
    Li B, Zhan Y, Liang Q, Xu C, Zhou X, Cai H, Zheng Y, Guo Y, Wang L, Qiu W, Cui B, Lu C, Qian R, Zhou P, Chen H, Liu Y, Chen S, Li X, Sun N., Free PMC Article

    03/5/2022
    The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.

    The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.
    Hammarsten O, Ljungqvist P, Redfors B, Wernbom M, Widing H, Lindahl B, Salahuddin S, Sammantar R, Jha S, Ravn-Fischer A, Brink M, Gisslen M., Free PMC Article

    02/19/2022
    A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding.

    A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding.
    Barrick SK, Greenberg L, Greenberg MJ., Free PMC Article

    01/22/2022
    Systemic inflammation induced by exacerbation of COPD or pneumonia in patients with COPD induces cardiac troponin elevation.

    Systemic inflammation induced by exacerbation of COPD or pneumonia in patients with COPD induces cardiac troponin elevation.
    Søyseth V, Kononova N, Neukamm A, Holmedahl NH, Hagve TA, Omland T, Einvik G., Free PMC Article

    12/11/2021
    Dynamic changes of high-sensitivity troponin T concentration during infancy: Clinical implications.

    Dynamic changes of high-sensitivity troponin T concentration during infancy: Clinical implications.
    Jehlicka P, Rajdl D, Sladkova E, Sykorova A, Sykora J., Free PMC Article

    12/4/2021
    Prognostic value of non-acute high sensitive troponin-T for cardiovascular morbidity and mortality in adults with congenital heart disease: A systematic review.

    Prognostic value of non-acute high sensitive troponin-T for cardiovascular morbidity and mortality in adults with congenital heart disease: A systematic review.
    Willinger L, Brudy L, Meyer M, Oberhoffer-Fritz R, Ewert P, Müller J.

    12/4/2021
    Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction.

    Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction.
    Biener M, Giannitsis E, Thum T, Bär C, Costa A, Andrzejewski T, Stoyanov KM, Vafaie M, Meder B, Katus HA, de Gonzalo-Calvo D, Mueller-Hennessen M.

    12/4/2021
    Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients.

    Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients.
    Pua CJ, Tham N, Chin CWL, Walsh R, Khor CC, Toepfer CN, Repetti GG, Garfinkel AC, Ewoldt JF, Cloonan P, Chen CS, Lim SQ, Cai J, Loo LY, Kong SC, Chiang CWK, Whiffin N, de Marvao A, Lio PM, Hii AA, Yang CX, Le TT, Bylstra Y, Lim WK, Teo JX, Padilha K, Silva GV, Pan B, Govind R, Buchan RJ, Barton PJR, Tan P, Foo R, Yip JWL, Wong RCC, Chan WX, Pereira AC, Tang HC, Jamuar SS, Ware JS, Seidman JG, Seidman CE, Cook SA., Free PMC Article

    10/30/2021
    Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation.

    Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation.
    Clippinger SR, Cloonan PE, Wang W, Greenberg L, Stump WT, Angsutararux P, Nerbonne JM, Greenberg MJ., Free PMC Article

    10/23/2021
    Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants.

    Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants.
    Pettinato AM, Ladha FA, Mellert DJ, Legere N, Cohn R, Romano R, Thakar K, Chen YS, Hinson JT., Free PMC Article

    10/16/2021
    One fits all hs troponin or more personalized dual markers strategies in the primary diagnostic assessment of patients with suspected acute coronary syndrome?

    One fits all hs troponin or more personalized dual markers strategies in the primary diagnostic assessment of patients with suspected acute coronary syndrome?
    Möckel M.

    10/9/2021
    Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes.

    Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes.
    Schuldt M, Johnston JR, He H, Huurman R, Pei J, Harakalova M, Poggesi C, Michels M, Kuster DWD, Pinto JR, van der Velden J., Free PMC Article

    10/9/2021
    The role of antibody-based troponin detection in cardiovascular disease: A critical assessment.

    The role of antibody-based troponin detection in cardiovascular disease: A critical assessment.
    Ma H, Cassedy A, O'Kennedy R., Free PMC Article

    10/2/2021
    Troponin T Mutation as a Cause of Left Ventricular Systolic Dysfunction in a Young Patient with Previous Surgical Correction of Aortic Coarctation.

    Troponin T Mutation as a Cause of Left Ventricular Systolic Dysfunction in a Young Patient with Previous Surgical Correction of Aortic Coarctation.
    Caiazza M, Lioncino M, Monda E, Di Fraia F, Verrillo F, Pacileo R, Amodio F, Rubino M, Cirillo A, Fusco A, Romeo E, Scatteia A, Dellegrottaglie S, Calabrò P, Sarubbi B, Baban A, Frisso G, Russo MG, Limongelli G., Free PMC Article

    09/25/2021
    Chondroid and Osseous Metaplasia of the Central Fibrous Body in Adolescent Hearts with Mutations in TNNI3 and TNNT2 genes.

    Chondroid and Osseous Metaplasia of the Central Fibrous Body in Adolescent Hearts with Mutations in TNNI3 and TNNT2 genes.
    Carreon CK, Sanders SP, Ashworth MT.

    09/11/2021
    Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.

    Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.
    Mori AA, Castro LR, Bortolin RH, Bastos GM, Oliveira VF, Ferreira GM, Hirata TDC, Fajardo CM, Sampaio MF, Moreira DAR, Pachón-Mateos JC, Correia EB, Sousa AGMR, Brión M, Carracedo A, Hirata RDC, Hirata MH.

    08/7/2021
    High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study.

    High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study.
    Berge K, Lyngbakken MN, Myhre PL, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H.

    07/3/2021
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