| FOSL1 transcriptionally regulates PHLDA2 to promote 5-FU resistance in colon cancer cells. | FOSL1 transcriptionally regulates PHLDA2 to promote 5-FU resistance in colon cancer cells.
Liu G, Wang H, Ran R, Wang Y, Li Y. | 07/19/2023 |
| Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole. | Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole.
Chia WK, Chia PY, Abdul Aziz NH, Shuib S, Mustangin M, Cheah YK, Khong TY, Wong YP, Tan GC., Free PMC Article | 06/15/2023 |
| Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway. | Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway.
Guo C, Liu S, Zhang T, Yang J, Liang Z, Lu S. | 10/29/2022 |
| RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia. | RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia.
Song G, Jin F. | 08/20/2022 |
| Tumor-Suppressing STF cDNA 3 Overexpression Suppresses Renal Fibrosis by Alleviating Anoikis Resistance and Inhibiting the PI3K/Akt Pathway. | Tumor-Suppressing STF cDNA 3 Overexpression Suppresses Renal Fibrosis by Alleviating Anoikis Resistance and Inhibiting the PI3K/Akt Pathway.
Xiao F, Liu X, Chen Y, Dai H. | 02/12/2022 |
| Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer. | Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer.
R Mangone F, Av Valoyes M, G do Nascimento R, Pf Conceição M, R Bastos D, C Pavanelli A, C Soares I, S de Mello E, Nonogaki S, Ab de T Osório C, A Nagai M. | 10/16/2021 |
| HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer. | HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer.
Koh SA, Lee KH. | 09/18/2021 |
| PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway. | PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway.
Lei L, Wang Y, Li ZH, Fei LR, Huang WJ, Zheng YW, Liu CC, Yang MQ, Wang Z, Zou ZF, Xu HT. | 08/28/2021 |
| PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway. | PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway.
Ma Z, Lou S, Jiang Z., Free PMC Article | 02/27/2021 |
| PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia. | PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia.
Ding L, Blitz MJ, Wing DA, Epstein AJ, Gjessing HK, Wilson ML. | 12/19/2020 |
| Increased CDKN1C and PHLDA2 and reduced IGF-2 abundances in placental tissue were related to BW and early period catch-up growth in full-term SGA infants. | Abundances of placental imprinted genes CDKN1C, PHLDA2 and IGF-2 are related to low birth weight and early catch-up growth in full-term infants born small for gestational age.
Xing Y, Liu H, Cui Y, Wang X, Tong X., Free PMC Article | 03/14/2020 |
| Authors demonstrated that TSSC3 was an independent prognostic marker for overall survival in osteosarcoma, and positive ATG5 expression associated with positive TSSC3 expression suggested a favorable prognosis for patients. Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. | TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis.
Zhao GS, Gao ZR, Zhang Q, Tang XF, Lv YF, Zhang ZS, Zhang Y, Tan QL, Peng DB, Jiang DM, Guo QN., Free PMC Article | 03/30/2019 |
| RanBP9/TSSC3 complex cooperatively suppress metastasis via downregulation of Src-dependent Akt pathway to expedite mitochondrial-associated anoikis. | RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.
Dai H, Lv YF, Yan GN, Meng G, Zhang X, Guo QN., Free PMC Article | 10/14/2017 |
| PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion. | Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis.
Jin F, Qiao C, Luan N, Li H., Free PMC Article | 12/31/2016 |
| TSSC3 was a prognostic marker in osteosarcoma. | The expression of TSSC3 and its prognostic value in patients with osteosarcoma.
Wang X, He H, Zhang K, Peng W. | 12/31/2016 |
| TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta | Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway.
Lv YF, Dai H, Yan GN, Meng G, Zhang X, Guo QN. | 07/30/2016 |
| Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant. | Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements.
Janssen AB, Tunster SJ, Heazell AE, John RM., Free PMC Article | 05/14/2016 |
| PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts. | The expression of the imprinted gene pleckstrin homology-like domain family A member 2 in placental tissues of preeclampsia and its effects on the proliferation, migration and invasion of trophoblast cells JEG-3.
Jin F, Qiao C, Luan N, Shang T. | 04/16/2016 |
| The gene expression pattern of CDKN1C, H19, IGF2, KCNQ1 and PHLDA2 genes was evaluated using RT-PCR. | Relevance of genomic imprinting in intrauterine human growth expression of CDKN1C, H19, IGF2, KCNQ1 and PHLDA2 imprinted genes.
Cordeiro A, Neto AP, Carvalho F, Ramalho C, Dória S., Free PMC Article | 06/20/2015 |
| elevated expression in placenta of growth restricted pregnancies [review] | The significance of elevated placental PHLDA2 in human growth restricted pregnancies.
Jensen AB, Tunster SJ, John RM. | 04/18/2015 |
| results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction | Placental expression of PHLDA2 in selective intrauterine growth restriction in monozygotic twins.
Shi X, He Z, Gao Y, Luo Y, Gou C, Fang Q. | 01/10/2015 |
| TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth | Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells.
Li Y, Huang Y, Lv Y, Meng G, Guo QN. | 09/27/2014 |
| TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells | TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells.
Huang Y, Dai H, Guo QN. | 10/20/2012 |
| A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight. | Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight.
Ishida M, Monk D, Duncan AJ, Abu-Amero S, Chong J, Ring SM, Pembrey ME, Hindmarsh PC, Whittaker JC, Stanier P, Moore GE., Free PMC Article | 06/2/2012 |
| The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction. | Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass.
Lewis RM, Cleal JK, Ntani G, Crozier SR, Mahon PA, Robinson SM, Harvey NC, Cooper C, Inskip HM, Godfrey KM, Hanson MA, Southampton Women's Survey Study Group, John RM., Free PMC Article | 04/14/2012 |