| Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes. | Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes.
Jeridi C, Rachdi A, Nabli F, Saied Z, Zouari R, Ben Mohamed D, Ben Said M, Masmoudi S, Ben Sassi S, Amouri R. | 03/15/2024 |
| The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons. | The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons.
Ulatowski L, Ghelfi M, West R, Atkinson J, Finno CJ, Manor D., Free PMC Article | 04/30/2022 |
| alpha-Tocopherol transfer protein (alpha-TTP). | α-Tocopherol transfer protein (α-TTP).
Arai H, Kono N. | 12/4/2021 |
| alpha-Tocopherol Transfer Protein Enhances alpha-Tocopherol Protective Effects in Lung A549 Cells. | α-Tocopherol Transfer Protein Enhances α-Tocopherol Protective Effects in Lung A549 Cells.
Tamura T, Otulakowski G, Post M, Kavanagh BP. | 10/24/2020 |
| Low TTP expression is associated with liver fibrosis. | linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin.
Wu JC, Luo SZ, Liu T, Lu LG, Xu MY. | 08/31/2019 |
| Authors show that a novel interaction between TTP and the CCR4-NOT subunit, CNOT9, is required for recruitment of the deadenylase complex. In addition to CNOT1, CNOT9 is now included in the identified CCR4-NOT subunits shown to interact with TTP. | Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.
Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE. | 03/30/2019 |
| Data show that, upon binding to its substrate, alpha-TTP acquires tendency to aggregation into thermodynamically stable high molecular weight oligomers with spheroidal particle formed by 24 protein monomers. Oligomerization is triggered by refolding of the N-terminus. These same oligomers are efficiently transported through an endothelial barrier and not through an epithelial one. | Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A., Free PMC Article | 02/2/2019 |
| alphaTTP does not appear to regulate the uptake and intracellular localization of different vitamin E congeners in cultured liver cells. | α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells.
Irías-Mata A, Sus N, Flory S, Stock D, Woerner D, Podszun M, Frank J., Free PMC Article | 12/22/2018 |
| These findings provide the basis for a proposed mechanistic model that describes TTP-facilitated trafficking of alpha-tocopherol through hepatocytes. | Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein.
Chung S, Ghelfi M, Atkinson J, Parker R, Qian J, Carlin C, Manor D., Free PMC Article | 05/7/2017 |
| Current results show that alphaTTP plays a role in endometrial carcinoma. Possibly endometrial cancer cells attempt to protect themselves from increasing oxidative stress by up-regulating alphaTTP. | Alpha tocopherol transfer protein (αTTP) is expressed in endometrial carcinoma and is correlated with FIGO stage and 5-year survival.
Heublein S, Vrekoussis T, Etzl R, Rotzoll D, Kuhn C, Faigle G, Navrozoglou I, Stefos T, Makrigiannakis A, Jeschke U. | 04/15/2017 |
| Single-nucleotide polymorphisms that are commonly found in healthy humans dramatically affect promoter activity of the TTPA gene. | Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms.
Ulatowski L, Dreussi C, Noy N, Barnholtz-Sloan J, Klein E, Manor D., Free PMC Article | 06/21/2014 |
| The crystal structure of the alpha-TTP-phosphatidylinositol phosphates (PIPs) complex revealed that the familial vitamin E deficiency-related arginine residues interacted with phosphate groups of the PIPs and that the PIPs binding caused the lid of the alpha-tocopherol-binding pocket to open. | Impaired α-TTP-PIPs interaction underlies familial vitamin E deficiency.
Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y, Arai H. | 06/22/2013 |
| study demonstrated that alpha -TTP can be upregulated in case of oxidative stress in BeWo trophoblast cells; speculate that possibly, alpha -TTP is notonly involved in normal pregnancy, but also in cases of pregnancy disorders with intense oxidative stress | Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWo.
Etzl RP, Vrekoussis T, Kuhn C, Schulze S, Pöschl JM, Makrigiannakis A, Jeschke U, Rotzoll DE. | 11/24/2012 |
| Data show that reduction ("knockdown") of tocopherol transfer protein (TTP) expression resulted in resistance to the vitamin E. | Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E.
Morley S, Thakur V, Danielpour D, Parker R, Arai H, Atkinson J, Barnholtz-Sloan J, Klein E, Manor D., Free PMC Article | 02/26/2011 |
| Substitution of residues in helices A8 (F165A and F169A) and A10 (I202A, V206A and M209A) decreased the rate of intermembrane ligand transfer as well as protein adsorption to phospholipid bilayers. | The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP).
Zhang WX, Thakur V, Lomize A, Pogozheva I, Panagabko C, Cecchini M, Baptist M, Morley S, Manor D, Atkinson J., Free PMC Article | 02/5/2011 |
| Observational study of genetic testing. (HuGE Navigator) | Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.
Booij JC, Bakker A, Kulumbetova J, Moutaoukil Y, Smeets B, Verheij J, Kroes HY, Klaver CC, van Schooneveld M, Bergen AA, Florijn RJ. | 12/5/2010 |
| Hydrophobic features of alpha-TTP dominating the binding energy between protein and membrane. | Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein.
Zhang WX, Frahm G, Morley S, Manor D, Atkinson J., Free PMC Article | 01/21/2010 |
| The vitamin E deficiency with hereditary motor neuropathy was found to be homozygous for a 513insTT mutation in exon 3 of the alpha-tocopherol transfer protein gene. | Isolated vitamin E deficiency mimicking distal hereditary motor neuropathy in a 13-year-old boy.
Fusco C, Frattini D, Pisani F, Gellera C, Della Giustina E. | 01/21/2010 |
| Genetic variation in TTPA and SEC14L2 is associated with serum alpha-tocopherol but does not have a direct effect on prostate cancer when vitamin E is administered. | Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk.
Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D, Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D., Free PMC Articles: PMC2644342, PMC2644342 | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk.
Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D, Wright ME, Peters U, Gunter MJ, Moore SC, Lawson KA, Yeager M, Weinstein SJ, Snyder K, Virtamo J, Albanes D., Free PMC Articles: PMC2644342, PMC2644342 | 03/25/2009 |
| Total deletion of the TTPA gene is expected to be associated with severe phenotype in AVED patients. | Ataxia with vitamin E deficiency associated with deafness.
Kara B, Uzümcü A, Uyguner O, Rosti RO, Koçbaş A, Ozmen M, Kayserili H. | 01/21/2010 |
| in first-trimester extravillous trophoblast, syncytiotrophoblast and amniotic epithelium | Immunohistochemical localization of alpha-tocopherol transfer protein and lipoperoxidation products in human first-trimester and term placenta.
Rotzoll DE, Scherling R, Etzl R, Stepan H, Horn LC, Pöschl JM. | 01/21/2010 |
| analysis of ligand transfer by the hepatic tocopherol transfer protein | Mechanisms of ligand transfer by the hepatic tocopherol transfer protein.
Morley S, Cecchini M, Zhang W, Virgulti A, Noy N, Atkinson J, Manor D., Free PMC Article | 01/21/2010 |
| The physiological role of TTP is anchored in its ability to direct vitamin E trafficking from the endocytic compartment to transport vesicles that deliver the vitamin to the site of secretion at the plasma membrane. | Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein.
Qian J, Atkinson J, Manor D. | 01/21/2010 |
| the positively charged surface of TTPA may serve to orient an interacting protein, which might function to regulate the release of alpha-T through an induced change in conformation of ATTP | Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency.
Min KC, Kovall RA, Hendrickson WA., Free PMC Article | 01/21/2010 |