| Biallelic Inactivating TUB Variants Cause Retinal Ciliopathy Impairing Biogenesis and the Structure of the Primary Cilium. | Biallelic Inactivating TUB Variants Cause Retinal Ciliopathy Impairing Biogenesis and the Structure of the Primary Cilium.
Ziccardi L, Niceta M, Stellacci E, Ciolfi A, Tatti M, Bruselles A, Mancini C, Barbano L, Cecchetti S, Costanzo E, Cappa M, Parravano M, Varano M, Tartaglia M, Cordeddu V., Free PMC Article | 03/3/2023 |
| A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family. | A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family.
Xu W, Xu M, Yin Q, Liu C, Cao Q, Deng Y, Liu S, He G., Free PMC Article | 01/21/2023 |
| Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. | Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p.
Wang P, Wang Z, Zhang M, Wu Q, Shi F. | 03/20/2021 |
| Candidate variants in TUB are associated with familial tremor. | Candidate variants in TUB are associated with familial tremor.
Sailani MR, Jahanbani F, Abbott CW, Lee H, Zia A, Rego S, Winkelmann J, Hopfner F, Khan TN, Katsanis N, Müller SH, Berg D, Lyman KM, Mychajliw C, Deuschl G, Bernstein JA, Kuhlenbäumer G, Snyder MP., Free PMC Article | 11/21/2020 |
| Studied the expression and distribution patterns of tubby bipartite transcription factor (TUB) in the hypothalamus and in adipose tissue in obese and healthy controls. | TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.
Nies VJM, Struik D, Wolfs MGM, Rensen SS, Szalowska E, Unmehopa UA, Fluiter K, van der Meer TP, Hajmousa G, Buurman WA, Greve JW, Rezaee F, Shiri-Sverdlov R, Vonk RJ, Swaab DF, Wolffenbuttel BHR, Jonker JW, van Vliet-Ostaptchouk JV. | 03/16/2019 |
| Tubby and Tulp1 mediated phagocytosis through MerTK-dependent signaling with non-muscle myosin II redistribution leading to colocalization of phagocytosed vesicles with rearranged NMMIIA. | Synergistic interaction of tubby and tubby-like protein 1 (Tulp1).
Caberoy NB., Free PMC Article | 07/26/2014 |
| Tubby and Tulp1 are bridging molecules with their N-terminal region as MERTK-binding domain and C-terminal region as phagocytosis prey-binding domain. | Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.
Caberoy NB, Zhou Y, Li W., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes. | Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.
Caberoy NB, Maiguel D, Kim Y, Li W., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
Chung WK, Patki A, Matsuoka N, Boyer BB, Liu N, Musani SK, Goropashnaya AV, Tan PL, Katsanis N, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Tiwari HK., Free PMC Article | 01/11/2009 |
| TUB is a candidate gene for late-onset obesity in humans | TUB is a candidate gene for late-onset obesity in women.
Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD, Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD. | 01/21/2010 |
| Genetic variation of the TUB gene was associated with both body composition and macronutrient intake, suggesting that TUB might influence eating behavior | Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women.
van Vliet-Ostaptchouk JV, Onland-Moret NC, Shiri-Sverdlov R, van Gorp PJ, Custers A, Peeters PH, Wijmenga C, Hofker MH, van der Schouw YT, van Vliet-Ostaptchouk JV, Onland-Moret NC, Shiri-Sverdlov R, van Gorp PJ, Custers A, Peeters PH, Wijmenga C, Hofker MH, van der Schouw YT., Free PMC Articles: PMC2157487, PMC2157487 | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | TUB is a candidate gene for late-onset obesity in women.
Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD, Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesInherited genetic variant predisposes to aggressive but not indolent prostate cancer.
Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, Trent JM, Duggan D, Carpten J, Grönberg H, Isaacs WB. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women.
van Vliet-Ostaptchouk JV, Onland-Moret NC, Shiri-Sverdlov R, van Gorp PJ, Custers A, Peeters PH, Wijmenga C, Hofker MH, van der Schouw YT, van Vliet-Ostaptchouk JV, Onland-Moret NC, Shiri-Sverdlov R, van Gorp PJ, Custers A, Peeters PH, Wijmenga C, Hofker MH, van der Schouw YT. Identification of TUB as a novel candidate gene influencing body weight in humans.
Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, van Gorp PJ, Lindsey PJ, van Tilburg JH, Zhernakova S, Feskens EJ, van der A DL, Dollé ME, van Haeften TW, Koeleman BP, Hofker MH, Wijmenga C, Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, van Gorp PJ, Lindsey PJ, van Tilburg JH, Zhernakova S, Feskens EJ, van der A DL, Dollé ME, van Haeften TW, Koeleman BP, Hofker MH, Wijmenga C. | 03/13/2008 |
| TUB could be an important factor in controlling the central regulation of body weight in humans. | Identification of TUB as a novel candidate gene influencing body weight in humans.
Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, van Gorp PJ, Lindsey PJ, van Tilburg JH, Zhernakova S, Feskens EJ, van der A DL, Dollé ME, van Haeften TW, Koeleman BP, Hofker MH, Wijmenga C, Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, van Gorp PJ, Lindsey PJ, van Tilburg JH, Zhernakova S, Feskens EJ, van der A DL, Dollé ME, van Haeften TW, Koeleman BP, Hofker MH, Wijmenga C. | 01/21/2010 |
| found the presence of tubby protein both in normal weight and in obese subjects; however in the latter an isoelectric point shift toward the acidic end was observed | Tubby protein in human lymphocytes from normal weight and obese subjects.
Giannaccini G, Giusti L, Santini F, Marsili A, Betti L, Mascia G, Pelosini C, Baroni S, Ciregia F, Fabbrini L, Lucacchini A, Vitti P, Pinchera A. | 01/21/2010 |
| Mouse Tubby protein may function as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression. | G-protein signaling through tubby proteins.
Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. | 03/31/2003 |
| Crystal structure of the core domain of the mouse Tubby protein. | Implication of tubby proteins as transcription factors by structure-based functional analysis.
Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L. | 03/31/2003 |