| Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. | Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy.
He X, Liu J, Xiao X, Zhang S, Wang X, Liu J, Liu Z, Wang J, Liu X, Li G, Yang P., Free PMC Article | 01/7/2023 |
| MARCH1 Controls an Exhaustion-like Program of Effector CD4(+) T Cells Promoting Allergic Airway Inflammation. | MARCH1 Controls an Exhaustion-like Program of Effector CD4(+) T Cells Promoting Allergic Airway Inflammation.
Castellanos CA, Hiam-Galvez KJ, Ishido S, Satpathy AT, Shin JS. | 10/1/2022 |
| Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1. | Lymph node-resident dendritic cells drive T(H)2 cell development involving MARCH1.
Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS., Free PMC Article | 03/12/2022 |
| Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice. | Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.
Majdoubi A, Lee JS, Kishta OA, Balood M, Moulefera MA, Ishido S, Talbot S, Cheong C, Alquier T, Thibodeau J., Free PMC Article | 04/24/2021 |
| The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation. | The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.
Wu J, Xia L, Yao X, Yu X, Tumas KC, Sun W, Cheng Y, He X, Peng YC, Singh BK, Zhang C, Qi CF, Bolland S, Best SM, Gowda C, Huang R, Myers TG, Long CA, Wang RF, Su XZ., Free PMC Article | 09/26/2020 |
| March1 ubiquitin-dependent MHCII turnover is critical to maintain homeostasis of lipid rafts and the tetraspanin web in dendritic cells. | MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells.
Oh J, Perry JSA, Pua H, Irgens-Möller N, Ishido S, Hsieh CS, Shin JS., Free PMC Article | 03/23/2019 |
| Results show that MARCH1 deficiency results in sex-specific changes in body weight, adiposity, and increases glucose clearance. Genetic association study for MARCH1 in type 2 diabetes risk in publicly-available datasets found evidence suggestive of association. These data show a link between immune function and diabetes implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance in sex-specific manner. | The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.
Bhagwandin C, Ashbeck EL, Whalen M, Bandola-Simon J, Roche PA, Szajman A, Truong SM, Wertheim BC, Klimentidis YC, Ishido S, Renquist BJ, Lybarger L., Free PMC Article | 03/23/2019 |
| found downstream sequence elements, present in the first coding exon of March-I in antigen-presenting cells (APCs), that confer regulation of March-I expression in activated APCs | A major isoform of the E3 ubiquitin ligase March-I in antigen-presenting cells has regulatory sequences within its gene.
Kaul S, Mittal SK, Roche PA., Free PMC Article | 01/19/2019 |
| unexpected intersection between MHC I and MHC II such that the surface expression of both molecules are indirectly and directly regulated by MARCH1 ubiquitination, respectively. | MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.
Wilson KR, Liu H, Healey G, Vuong V, Ishido S, Herold MJ, Villadangos JA, Mintern JD., Free PMC Article | 01/12/2019 |
| Study shows march1-dependent modulation of donor MHC II on CD103(+) dendritic cells mitigates alloimmunity | March1-dependent modulation of donor MHC II on CD103(+) dendritic cells mitigates alloimmunity.
Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C., Free PMC Article | 12/22/2018 |
| these results demonstrate a role of March1 E3 ubiquitin ligase in modulating allergic responses | March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.
Kishta OA, Sabourin A, Simon L, McGovern T, Raymond M, Galbas T, Majdoubi A, Ishido S, Martin JG, Thibodeau J., Free PMC Article | 10/13/2018 |
| March1 loss-of-function enhances, and March1 overexpression impairs, hepatic insulin sensitivity in mice. | MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.
Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N., Free PMC Article | 09/8/2018 |
| We conclude that MARCH1 exerts MHCII-independent effects that regulate the innate arm of immunity | MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.
Galbas T, Raymond M, Sabourin A, Bourgeois-Daigneault MC, Guimont-Desrochers F, Yun TJ, Cailhier JF, Ishido S, Lesage S, Cheong C, Thibodeau J. | 08/19/2017 |
| March-I ubiquitination prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells | Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells.
Cho KJ, Walseng E, Ishido S, Roche PA., Free PMC Article | 04/30/2016 |
| IL-10 stimulates expression of the E3 ubiquitin ligase March-I in activated macrophages, thereby down-regulating MHC-II, CD86, and antigen presentation to CD4 T cells. | Interleukin 10 (IL-10)-mediated Immunosuppression: MARCH-I INDUCTION REGULATES ANTIGEN PRESENTATION BY MACROPHAGES BUT NOT DENDRITIC CELLS.
Mittal SK, Cho KJ, Ishido S, Roche PA., Free PMC Article | 04/23/2016 |
| Dendritic cells co-cultivated with antigen-specific induced Tregs expressed high levels of MARCH1. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 on MARCH1 & CD83 expression. | Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Chattopadhyay G, Shevach EM., Free PMC Article | 02/22/2014 |
| DCs deficient in MARCH1 or MHCII ubiquitination both failed to generate antigen-specific T reg cells in vivo and in vitro. | MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells.
Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS., Free PMC Article | 11/16/2013 |
| aberrant degradation of spleen DCs MARCH1-mediated ubiquitinated proteins is involved during the earliest stage of MODS development. | Altered MARCH1 ubiquination-regulated dendritic cell immune functions during the early stage of zymosan-induced multiple organ dysfunction syndrome (MODS) in mice.
Li F, Lu JY, Liu Q, Wang HW, Guo H. | 09/21/2013 |
| IL-10 can have opposite effects on MARCH1 regulation in different cell types. | MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression.
Galbas T, Steimle V, Lapointe R, Ishido S, Thibodeau J. | 10/6/2012 |
| Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1). | Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
Corcoran K, Jabbour M, Bhagwandin C, Deymier MJ, Theisen DL, Lybarger L., Free PMC Article | 12/17/2011 |
| found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1 | CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
Tze LE, Horikawa K, Domaschenz H, Howard DR, Roots CM, Rigby RJ, Way DA, Ohmura-Hoshino M, Ishido S, Andoniou CE, Degli-Esposti MA, Goodnow CC., Free PMC Article | 02/26/2011 |
| Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase March-I results in the selective degradation of internalized pMHC-II. | Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells.
Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA., Free PMC Article | 01/22/2011 |
| MARCH-I may function as a housekeeper of conventional dendritic cell in the steady state. | Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells.
Ohmura-Hoshino M, Matsuki Y, Mito-Yoshida M, Goto E, Aoki-Kawasumi M, Nakayama M, Ohara O, Ishido S. | 01/21/2010 |
| MARCH1 expression is regulated at a posttranscriptional level by trafficking within the endolysosomal pathway where MARCH1 is proteolyzed. | Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.
Jabbour M, Campbell EM, Fares H, Lybarger L., Free PMC Article | 01/21/2010 |
| The function of MHC II in B cells is regulated through ubiquitination by MARCH-I. | Novel regulation of MHC class II function in B cells.
Matsuki Y, Ohmura-Hoshino M, Goto E, Aoki M, Mito-Yoshida M, Uematsu M, Hasegawa T, Koseki H, Ohara O, Nakayama M, Toyooka K, Matsuoka K, Hotta H, Yamamoto A, Ishido S., Free PMC Article | 01/21/2010 |