| Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling. | Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling.
Wu Y, Li C, Khan AA, Chen K, Su R, Xu S, Sun Y, Gao F, Wang K, Wang X, Lian Z, Wang S, Yu M, Hu X, Yang F, Zheng S, Qiu N, Liu Z, Xu X., Free PMC Article | 11/1/2023 |
| CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. | CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y., Free PMC Article | 04/23/2022 |
| Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. The stabilized Insig-2 downregulates lipogenesis through inhibiting the SREBP pathway, helping to channel the carbon flux to ATP generation and protecting myotubes from lipid over-accumulation. | Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.
Zhou ZS, Li MX, Liu J, Jiao H, Xia JM, Shi XJ, Zhao H, Chu L, Liu J, Qi W, Luo J, Song BL., Free PMC Article | 04/11/2020 |
| CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting | CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting.
Zhang Y, Liu Y, Chen L, Wang Y, Han J., Free PMC Article | 06/15/2019 |
| These results suggest that PPARalpha is a trans-acting factor that enhances Insig2a gene expression, thereby suppressing SREBP-1c processing during fasting. | PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting.
Lee JH, Kang HS, Park HY, Moon YA, Kang YN, Oh BC, Song DK, Bae JH, Im SS., Free PMC Article | 04/27/2019 |
| Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. | Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA., Free PMC Article | 08/4/2018 |
| INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c-driven lipogenesis. | SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.
Roqueta-Rivera M, Esquejo RM, Phelan PE, Sandor K, Daniel B, Foufelle F, Ding J, Li X, Khorasanizadeh S, Osborne TF., Free PMC Article | 07/1/2017 |
| These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia. | Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.
Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA., Free PMC Article | 06/10/2017 |
| the essential role of Insig1,2 proteins in the sterol homeostasis of enterocytes. | Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.
McFarlane MR, Liang G, Engelking LJ., Free PMC Article | 03/29/2014 |
| Insig deficiency in skin causes accumulation of cholesterol precursors, and this impairs normal hair development | Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.
Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G., Free PMC Article | 05/31/2010 |
| Data show that REV-ERBalpha participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2. | REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Lo Sasso G, Moschetta A, Schibler U., Free PMC Article | 01/21/2010 |
| Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 and insig-2 at an early phase in adipocyte differentiation. | Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
Ka SO, Kim KA, Kwon KB, Park JW, Park BH. | 01/21/2010 |
| Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c,-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress | Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.
Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL., Free PMC Article | 01/21/2010 |
| Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains | Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.
Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE. | 01/21/2010 |
| A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha agonists or infected with constitutively active FXRalpha. | Regulation of hepatic Insig-2 by the farnesoid X receptor.
Hubbert ML, Zhang Y, Lee FY, Edwards PA. | 01/21/2010 |
| a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes | Identification of a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes.
Lee S, Lee DK, Choi E, Lee JW. | 01/21/2010 |
| Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. | Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS., Free PMC Article | 01/21/2010 |
| Treatment of pregnant mice with the HMG-CoA reductase inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting. | Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.
Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G., Free PMC Article | 01/21/2010 |
| Results define Insig proteins 1 and 2 as essential elements of the feedback inhibition system of cholesterol synthesis in mouse liver. | Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS., Free PMC Article | 01/21/2010 |