| Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2. | Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2.
Kim HS, Lee YS, Dong SM, Kim HJ, Lee DE, Kang HW, Kim MJ, Park JS., Free PMC Article | 04/4/2024 |
| N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters. | N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.
Bhanja A, Seeley-Fallen MK, Lazzaro M, Upadhyaya A, Song W., Free PMC Article | 12/20/2023 |
| nWASP Inhibition Increases Wound Healing via TrKb/PLCgamma Signalling. | nWASP Inhibition Increases Wound Healing via TrKb/PLCγ Signalling.
Frugtniet BA, Ruge F, Sanders AJ, Owen S, Harding KG, Jiang WG, Martin TA., Free PMC Article | 03/1/2023 |
| Loss of Wasl improves pancreatic cancer outcome. | Loss of Wasl improves pancreatic cancer outcome.
Hidalgo-Sastre A, Desztics J, Dantes Z, Schulte K, Ensarioglu HK, Bassey-Archibong B, Öllinger R, Engleiter T, Rayner L, Einwächter H, Daniel JM, Altaee ASA, Steiger K, Lesina M, Rad R, Reichert M, von Figura G, Siveke JT, Schmid RM, Lubeseder-Martellato C., Free PMC Article | 05/22/2021 |
| N-Wasp Regulates Oligodendrocyte Myelination. | N-Wasp Regulates Oligodendrocyte Myelination.
Katanov C, Novak N, Vainshtein A, Golani O, Dupree JL, Peles E., Free PMC Article | 01/9/2021 |
| N-WASP regulates the mobility of the B cell receptor.N-WASP regulates the diffusivity of CD19, a stimulatory co-receptor, but not that of FcgammaRIIB. | WASP family proteins regulate the mobility of the B cell receptor during signaling activation.
Rey-Suarez I, Wheatley BA, Koo P, Bhanja A, Shu Z, Mochrie S, Song W, Shroff H, Upadhyaya A., Free PMC Article | 04/25/2020 |
| ta indicated that N-WASP deficiency in HGFs increases the production of inflammatory cytokine and is regulated via NF-kappaB and MAPK signaling pathways | N-WASP knockdown upregulates inflammatory cytokines expression in human gingival fibroblasts.
Wang Y, Kang W, Shang L, Song A, Ge S. | 02/8/2020 |
| N-WASP has an early tumour suppressive role in APC-induced intestinal carcinogenesis. | Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM., Free PMC Article | 10/26/2019 |
| conditional N-WASP knockout in keratinocytes leads to compromised skin barrier, higher infiltration of immune cells and hyperproliferation of keratinocytes due to increased production of cytokines highlighting the importance of N-WASP in maintaining the skin homeostasis. | Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.
Kalailingam P, Tan HB, Jain N, Sng MK, Chan JSK, Tan NS, Thanabalu T., Free PMC Article | 02/23/2019 |
| N-WASP regulates cortical neuron migration mainly through its polyPro and VCA domains. | [N-WASP regulates cortical neuron migration through its polyPro and VCA domains].
Shen XL, Lu YC, Jia ZL, Wu Q. | 12/22/2018 |
| It has been shown in a genetic psoriasis model that N-WASP controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. | Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C., Free PMC Article | 12/1/2018 |
| Wound healing was faster in N-WASP(FKO) compared to controls, and N-WASP deficient fibroblasts were found to have enhanced collagen gel contraction properties. These results suggest that N-WASP deficiency in fibroblasts improves wound healing by growth factor-mediated enhancement of keratinocyte proliferation and increased wound contraction. | Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure.
Jain N, Kalailingam P, Tan KW, Tan HB, Sng MK, Chan JS, Tan NS, Thanabalu T., Free PMC Article | 06/9/2018 |
| Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP. | Myogenic differentiation depends on the interplay of Grb2 and N-WASP.
Mitra P, Thanabalu T. | 10/7/2017 |
| Data (including data from studies in knockout mice) suggest that Cnr1 (cannabinoid receptor 1) activation impacts actin cytoskeleton polymerization/stability via Wasl in growth cones of developing neurons and in synaptic spines of mature neurons. | The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.
Njoo C, Agarwal N, Lutz B, Kuner R., Free PMC Article | 04/16/2016 |
| Our data suggests that the N-WASP-Arp2/3 actin polymerization machinery generates branched-actin arrays at an advanced stage of blood-testis barrier remodeling. | N-wasp is required for structural integrity of the blood-testis barrier.
Xiao X, Mruk DD, Tang EI, Massarwa R, Mok KW, Li N, Wong CK, Lee WM, Snapper SB, Shilo BZ, Schejter ED, Cheng CY., Free PMC Article | 08/8/2015 |
| N-terminus of Cas associates with the FAK-N-WASP complex at the protrusive edge of the cell and that the C-terminus of Cas associates with the immobilized integrin-SFK cluster. | N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.
Zhang X, Moore SW, Iskratsch T, Sheetz MP., Free PMC Article | 04/11/2015 |
| Toca-1(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP. | Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP.
George B, Jain N, Fen Chong P, Hou Tan J, Thanabalu T. | 09/13/2014 |
| N-WASP plays a unique role in the down-regulation of BCR signaling at the cell surface. | N-wasp is essential for the negative regulation of B cell receptor signaling.
Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg CI, Westerberg LS, Snapper SB, Zhao X, Song W., Free PMC Article | 07/12/2014 |
| Our results suggest that N-WASP plays a critical role in normal brain development and implicate actin cytoskeleton regulation as a vulnerable axis frequently deregulated in hydrocephalus. | Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology.
Jain N, Lim LW, Tan WT, George B, Makeyev E, Thanabalu T. | 05/24/2014 |
| These findings elucidate how junctional actin dynamics via Cdc42/N-WASP signaling cell-autonomously control not only epithelial delamination but also cell differentiation during mammalian organogenesis. | Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation.
Kesavan G, Lieven O, Mamidi A, Öhlin ZL, Johansson JK, Li WC, Lommel S, Greiner TU, Semb H., Free PMC Article | 03/22/2014 |
| actin dynamics regulated by the balance of N-WASP and cofilin activities determines the biphasic response of GIIS. | Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion.
Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe M, Oiso Y, Takenawa T, Seino S., Free PMC Article | 02/8/2014 |
| Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly. | WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.
Donnelly SK, Weisswange I, Zettl M, Way M., Free PMC Article | 01/18/2014 |
| N-WASP-mediated actin nucleation of branched microfilament networks is specifically required for the maintenance of foot processes. | N-wasp is required for stabilization of podocyte foot processes.
Schell C, Baumhakl L, Salou S, Conzelmann AC, Meyer C, Helmstädter M, Wrede C, Grahammer F, Eimer S, Kerjaschki D, Walz G, Snapper S, Huber TB., Free PMC Article | 07/27/2013 |
| These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly. | Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.
Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB., Free PMC Article | 02/9/2013 |
| Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis. | Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.
Dart AE, Donnelly SK, Holden DW, Way M, Caron E. | 01/26/2013 |