| PD-1H/VISTA mediates immune evasion in acute myeloid leukemia. | PD-1H/VISTA mediates immune evasion in acute myeloid leukemia.
Kim TK, Han X, Hu Q, Vandsemb EN, Fielder CM, Hong J, Kim KW, Mason EF, Plowman RS, Wang J, Wang Q, Zhang JP, Badri T, Sanmamed MF, Zheng L, Zhang T, Alawa J, Lee SW, Zeidan AM, Halene S, Pillai MM, Chandhok NS, Lu J, Xu ML, Gore SD, Chen L., Free PMC Article | 02/9/2024 |
| VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms. | VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms.
Zhang K, Zakeri A, Alban T, Dong J, Ta HM, Zalavadia AH, Branicky A, Zhao H, Juric I, Husich H, Parthasarathy PB, Rupani A, Drazba JA, Chakraborty AA, Ching-Cheng Huang S, Chan T, Avril S, Wang LL., Free PMC Article | 02/5/2024 |
| VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. | VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim SH, Adams TS, Hu Q, Shin HJ, Chae G, Lee SE, Sharma L, Kwon HK, Lee FY, Park HJ, Huh WJ, Manning E, Kaminski N, Sauler M, Chen L, Song JW, Kim TK, Kang MJ., Free PMC Article | 10/20/2023 |
| The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease. | The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease.
Fu J, Li S, Ma H, Yang J, Pagnotti GM, Brown LM, Weiss SJ, Mapara MY, Lentzsch S., Free PMC Article | 07/20/2023 |
| VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils. | VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils.
Vivian Ma YH, Sparkes A, Saha S, Gariépy J. | 09/24/2022 |
| Kidney VISTA prevents IFN-gamma/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury. | Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.
Kim MG, Yun D, Kang CL, Hong M, Hwang J, Moon KC, Jeong CW, Kwak C, Kim DK, Oh KH, Joo KW, Kim YS, Lee DS, Han SS., Free PMC Article | 02/19/2022 |
| VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology. | VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology.
Borggrewe M, Kooistra SM, Wesseling EM, Gierschek FL, Brummer ML, Nowak EC, Medeiros-Furquim T, Otto TA, Lee SW, Noelle RJ, Eggen BJL, Laman JD., Free PMC Article | 12/4/2021 |
| VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation. | VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation.
Tham EL, Freeley SJ, Bearder S, Barros FF, Cragg MS, Mócsai A, Robson MG. | 10/16/2021 |
| Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir(-/-) murine psoriasis. | Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir(-/-) murine psoriasis.
Qie C, Jiang J, Liu W, Hu X, Chen W, Xie X, Liu J., Free PMC Article | 06/5/2021 |
| Defining the Signature of VISTA on Myeloid Cell Chemokine Responsiveness. | Defining the Signature of VISTA on Myeloid Cell Chemokine Responsiveness.
Broughton TWK, ElTanbouly MA, Schaafsma E, Deng J, Sarde A, Croteau W, Li J, Nowak EC, Mabaera R, Smits NC, Kuta A, Noelle RJ, Lines JL., Free PMC Article | 11/21/2020 |
| PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. | PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.
Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. | 09/12/2020 |
| VISTA is therefore a distinctive negative checkpoint regulator of naive T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance. | VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ., Free PMC Article | 05/23/2020 |
| VISTA may play an essential role in the acceptance of corneal allografts via involvement with allospecific ACAID, which suppresses T cell infiltration into the cornea. | VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege.
Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. | 02/29/2020 |
| findings identify a mechanism by which VISTA may engender resistance to anti-tumour immune responses, as well as an unexpectedly determinative role for pH in immune co-receptor engagement | VISTA is an acidic pH-selective ligand for PSGL-1.
Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L, Martin GH, Lemar H, Cayton T, Huang RY, Deng X, Nayeem A, Chen H, Ergel B, Rizzo JM, Yamniuk AP, Dutta S, Ngo J, Shorts AO, Ramakrishnan R, Kozhich A, Holloway J, Fang H, Wang YK, Yang Z, Thiam K, Rakestraw G, Rajpal A, Sheppard P, Quigley M, Bahjat KS, Korman AJ. | 11/23/2019 |
| findings support a critical role of intrinsic PD-1H in the regulation of inflammatory responses to allergens. | A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma.
Liu H, Li X, Hu L, Zhu M, He B, Luo L, Chen L., Free PMC Article | 10/5/2019 |
| The results suggest that VISTA is involved in the regulation of Th2 cell generation and Th2 cell-mediated antibody production and regulates asthmatic responses, especially in the effector phase. | The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses.
Ohno T, Zhang C, Kondo Y, Kang S, Furusawa E, Tsuchiya K, Miyazaki Y, Azuma M. | 02/23/2019 |
| Our results indicate that PD-1H is required for maintenance of iTreg pool size by promoting its differentiation and preventing its conversion to other CD4(+) T cell subsets. These findings may have important implications for manipulating Tregs to control inflammation. | Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.
Wang Q, He J, Flies DB, Luo L, Chen L., Free PMC Article | 02/2/2019 |
| The study demonstrates a novel role of v-domain immunoglobulin suppressor of T cell activation (VISTA) in regulating this inflammatory axis. In the IMQ-induced psoriasis model, VISTA deficiency augmented the inflammatory responses of dendritic cells, gammadelta T cells, and Th17 cells, resulting in exacerbated psoriasiform dermatitis. | Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L., Free PMC Article | 12/22/2018 |
| VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium | VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes.
Ceeraz S, Eszterhas SK, Sergent PA, Armstrong DA, Ashare A, Broughton T, Wang L, Pechenick D, Burns CM, Noelle RJ, Vincenti MP, Fava RA., Free PMC Article | 08/11/2018 |
| Dies1 expression loss is a recurrent event in gastric cancer, caused by promoter methylation. | Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation.
Oliveira P, Carvalho J, Rocha S, Azevedo M, Reis I, Camilo V, Sousa B, Valente S, Paredes J, Almeida R, Huntsman D, Oliveira C., Free PMC Article | 06/16/2018 |
| Blockade with a combination of iNOS/NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell responsiveness. | Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus.
Green KA, Wang L, Noelle RJ, Green WR., Free PMC Article | 11/7/2015 |
| The ectopic expression of miR-125b blocks ESC differentiation at the epiblast stage, and this arrest is rescued by restoring the expression of Dies1. | miR-125b regulates the early steps of ESC differentiation through dies1 in a TGF-independent manner.
Battista M, Musto A, Navarra A, Minopoli G, Russo T, Parisi S., Free PMC Article | 10/3/2015 |
| study demonstrates the nonredundant role of VISTA that is distinct from the PD-1/PD-L1 pathway in controlling T-cell activation | Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L., Free PMC Article | 08/29/2015 |
| PD-1H is a coinhibitory receptor on alloreactive T cells and functions in the regulation of T cell tolerance. | Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.
Flies DB, Higuchi T, Chen L., Free PMC Article | 08/22/2015 |
| VISTA is a negative checkpoint regulator whose loss of function lowers the threshold for T-cell activation. | Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ., Free PMC Article | 05/2/2015 |