| UVRAG: orchestrating the initiation of reticulophagy. | UVRAG: orchestrating the initiation of reticulophagy.
Qian X, Sun J, Cui Y., | 03/11/2024 |
| TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG. | TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.
Xu C, Wu J, Wu Y, Ren Z, Yao Y, Chen G, Fang EF, Noh JH, Liu YU, Wei L, Chen X, Sima J., Free PMC Article | 02/12/2022 |
| GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. | GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
Zhang X, Wang L, Ireland SC, Ahat E, Li J, Bekier ME 2nd, Zhang Z, Wang Y., Free PMC Article | 08/22/2020 |
| UVRAG is ubiquitinated by SMURF1 at lysine residues 517 and 559, which decreases the association of UVRAG with RUBCN and promotes autophagosome maturation. | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z., Free PMC Article | 06/20/2020 |
| miR183 inhibits starvationinduced autophagy and apoptosis by targeting UVRAG in human gastric cancer cells. | miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene.
Yuan Y, Zhang Y, Han L, Sun S, Shu Y. | 03/2/2019 |
| results establish UVRAG as an important effector for melanocytes' response to alpha-MSH signaling as a direct target of MITF and reveal the molecular basis underlying the association between oncogenic BRAF and compromised UV protection in melanoma. | Central role of autophagic UVRAG in melanogenesis and the suntan response.
Yang Y, Jang GB, Yang X, Wang Q, He S, Li S, Quach C, Zhao S, Li F, Yuan Z, Lee HR, Zhong H, Liang C., Free PMC Article | 10/6/2018 |
| our study showed that the expression of miR-125b-5p is downregulated in peripheral blood mononuclear cells of systemic lupus erythematosus patients, accompanied by increased UVRAG expression and autophagy activation | miR-125b is downregulated in systemic lupus erythematosus patients and inhibits autophagy by targeting UVRAG.
Cao W, Qian G, Luo W, Liu X, Pu Y, Hu G, Han L, Yuan L, A X, Deng D. | 09/22/2018 |
| To induce the redistribution of Beclin 1 among its self-associated form or Atg14L/UVRAG-containing complexes enhances both autophagy and endolysosomal trafficking. | Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.
Wu S, He Y, Qiu X, Yang W, Liu W, Li X, Li Y, Shen HM, Wang R, Yue Z, Zhao Y., Free PMC Article | 09/1/2018 |
| miR-216b enhances the efficacy of vemurafenib and reverses drug resistance by targeting Beclin-1, UVRAG and ATG5 in melanoma. | miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma.
Luo M, Wu L, Zhang K, Wang H, Wu S, O'Connell D, Gao T, Zhong H, Yang Y. | 07/21/2018 |
| Our findings suggest that up-regulation of UVRAG by HDAC1 inhibition potentiates DNA-damage-mediated cell death in colorectal cancer cells | Up-regulation of UVRAG by HDAC1 Inhibition Attenuates 5FU-induced Cell Death in HCT116 Colorectal Cancer Cells.
Jo YK, Park NY, Shin JH, Jo DS, Bae JE, Choi ES, Maeng S, Jeon HB, Roh SA, Chang JW, Kim JC, Cho DH. | 01/6/2018 |
| UVRAG plays an essential role in protecting cells from UV-induced DNA damage by activating the nucleotide excision repair pathway | Autophagy modulator plays a part in UV protection.
Yang Y, Quach C, Liang C., Free PMC Article | 12/30/2017 |
| UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition. | Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.
Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon YH, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C., Free PMC Article | 08/19/2017 |
| Under-expression of UVRAG is associated with colorectal cancer. | miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG.
Huangfu L, Liang H, Wang G, Su X, Li L, Du Z, Hu M, Dong Y, Bai X, Liu T, Yang B, Shan H., Free PMC Article | 11/5/2016 |
| UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect. | Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.
He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C., Free PMC Article | 04/16/2016 |
| HCV, by differentially inducing the expression of Rubicon and UVRAG, temporally regulated the autophagic flux to enhance its replication. | HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication.
Wang L, Tian Y, Ou JH., Free PMC Article | 02/13/2016 |
| tubulation requires mTOR activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that activate VPS34. | mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
Munson MJ, Allen GF, Toth R, Campbell DG, Lucocq JM, Ganley IG., Free PMC Article | 11/28/2015 |
| Beclin 1 and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells. | Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells.
Park JM, Tougeron D, Huang S, Okamoto K, Sinicrope FA., Free PMC Article | 10/17/2015 |
| Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR), reduces EGFR signaling, and suppresses cancer cell proliferation and tumor growth. | mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.
Kim YM, Jung CH, Seo M, Kim EK, Park JM, Bae SS, Kim DH., Free PMC Article | 04/18/2015 |
| The reports that Grb2, when in excess, interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 or Grb2. | Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer's disease-like scenario.
Roy K, Chakrabarti O, Mukhopadhyay D. | 04/4/2015 |
| UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. | UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C., Free PMC Article | 04/19/2014 |
| Akt1 may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation. | Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.
Yang W, Ju JH, Lee KM, Nam K, Oh S, Shin I. | 03/23/2013 |
| in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 interacts with the class III PI3K Vps34 in a complex with Beclin-1 and UVRAG | Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
Ma C, Wang N, Detre C, Wang G, O'Keeffe M, Terhorst C., Free PMC Article | 08/18/2012 |
| UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation. | A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.
Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C., Free PMC Article | 08/4/2012 |
| analysis of how the Beclin1 coiled-coil domain interface regulates homodimer and heterodimer formation with Atg14L and UVRAG | Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.
Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z, Zhao Y., Free PMC Article | 07/28/2012 |
| UVRAG has cytoprotective functions in the cytosol that control the localization of Bax in tumor cells exposed to apoptotic stimuli | A critical role for UVRAG in apoptosis.
Yin X, Cao L, Peng Y, Tan Y, Xie M, Kang R, Livesey KM, Tang D., Free PMC Article | 03/31/2012 |