| Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis. | Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.
Gupta A, Thirunavukkarasu S, Rangel-Moreno J, Ahmed M, Swanson RV, Mbandi SK, Smrcka AV, Kaushal D, Scriba TJ, Khader SA., | 04/15/2024 |
| Phospholipase C-epsilon defines a PACAP-stimulated pathway for secretion in the chromaffin cell. | Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
Chen X, Coffman BL, Brindley RL, Galpin JD, Ahern CA, Currie KPM, Smrcka AV, Axelrod D, Anantharam A., Free PMC Article | 11/28/2023 |
| Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection. | Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
Atchison DK, O'Connor CL, Converso-Baran K, Bergin IL, Zhang H, Wang Y, Hartman JR, Ju W, Smrcka AV, Ganesh SK, Bitzer M., Free PMC Article | 12/24/2022 |
| Results suggest that phospholipase C epsilon 1 (PLCepsilon1) is a potential regulator of tumor-infiltrating lymphocytes, functioning, at least in part, at the level of T cell trafficking and recruitment. | PLCε1 suppresses tumor growth by regulating murine T cell mobilization.
Strazza M, Adam K, Smrcka AV, Lerrer S, Mor A., Free PMC Article | 08/1/2020 |
| Plce1 deficiency in mice predisposes to glomerular damage secondary to hypertensive insults. | Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency.
Atchison DK, O'Connor CL, Menon R, Otto EA, Ganesh SK, Wiggins RC, Smrcka AV, Bitzer M., Free PMC Article | 07/18/2020 |
| The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 | Genome-Wide Association Mapping for Female Infertility in Inbred Mice.
Liu JL, Wang TS, Zhao M., Free PMC Article | 11/25/2017 |
| 2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress... | The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.
Tong J, Liu X, Vickstrom C, Li Y, Yu L, Lu Y, Smrcka AV, Liu QS., Free PMC Article | 08/19/2017 |
| study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury | Phospholipase Cε deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice.
Zhu X, Sun Y, Mu X, Guo P, Gao F, Zhang J, Zhu Y, Zhang X, Chen L, Ning Z, Bai Y, Ren J, Man M, Liu P, Hu L. | 06/24/2017 |
| PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis. | Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis.
Jiang T, Liu T, Li L, Yang Z, Bai Y, Liu D, Kong C., Free PMC Article | 12/31/2016 |
| Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon. | Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ.
Dusaban SS, Kunkel MT, Smrcka AV, Brown JH., Free PMC Article | 02/6/2016 |
| PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells. | Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.
Nagano T, Edamatsu H, Kobayashi K, Takenaka N, Yamamoto M, Sasaki N, Nishimura Y, Kataoka T., Free PMC Article | 06/20/2015 |
| a new pathway for TRPC6 activation by Phospholipase C epsilon | Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes.
Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, Fahlbusch M, Barth H, Smrcka A, Hildebrandt F, Gudermann T, Dietrich A., Free PMC Article | 05/23/2015 |
| findings reveal a pathway initiated by GPCR agonist-induced RhoA activation, in which PLCepsilon signals to PKD1-mediated phosphorylation of cytoskeletal proteins | PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.
Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J., Free PMC Article | 08/9/2014 |
| Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF. | Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.
Martins M, Warren S, Kimberley C, Margineanu A, Peschard P, McCarthy A, Yeo M, Marshall CJ, Dunsby C, French PM, Katan M., Free PMC Article | 08/31/2013 |
| PLCepsilon links G protein-coupled receptors (GPCR) to sustained PKD activation, providing a means for GPCR ligands that couple to RhoA to induce NF-kappaB signaling and promote neuroinflammation. | Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.
Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH., Free PMC Article | 05/4/2013 |
| These results reveal a crucial role of PLCepsilon in the development of skin inflammation and suggest a mechanism in which PLCepsilon induces the production of cytokines including IL-23 from keratinocytes, leading to the activation of IL-22-producing T cells. | Overexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration.
Takenaka N, Edamatsu H, Suzuki N, Saito H, Inoue Y, Oka M, Hu L, Kataoka T. | 11/24/2012 |
| results indicate that PLCvarepsilon has a crucial role in UVB-induced acute inflammatory reactions such as neutrophil infiltration and epidermal thickening by at least in part regulating expression of CXCL1/KC in skin cells such as keratinocytes and fibroblasts | Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC.
Oka M, Edamatsu H, Kunisada M, Hu L, Takenaka N, Sakaguchi M, Kataoka T, Nishigori C. | 11/24/2012 |
| PLCepsilon may be a key molecule regulating the signal pathway of bladder cancer proliferation | Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation.
Ling Y, Chunli L, Xiaohou W, Qiaoling Z. | 01/14/2012 |
| Phospholipase c-epsilon is a determinant of mouse islet insulin secretion that is under the control of Epac2. | Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.
Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG., Free PMC Article | 10/1/2011 |
| resistance to UVB-induced cell death conferred by the absence of PLCepsilon is closely related to the higher incidence of skin tumor formation. | Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death.
Oka M, Edamatsu H, Kunisada M, Hu L, Takenaka N, Dien S, Sakaguchi M, Kitazawa R, Norose K, Kataoka T, Nishigori C. | 11/13/2010 |
| PLCepsilon plays a crucial role in induction of proinflammatory cytokine expression in fibroblasts and keratinocytes at the challenged sites | Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Hu L, Edamatsu H, Takenaka N, Ikuta S, Kataoka T. | 02/15/2010 |
| Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. | Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Li M, Edamatsu H, Kitazawa R, Kitazawa S, Kataoka T. | 01/21/2010 |
| control of sarcoplasmic reticulum Ca2+ release, rather than Ca2+ influx through L-type Ca2+ channels, is the target of regulation of a novel signal transduction pathway involving activation of Epac, PLCepsilon, PKCepsilon, and CamKII | Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV., Free PMC Article | 01/21/2010 |
| PLC epsilon activation is involved in skin inflammation. | Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Ikuta S, Edamatsu H, Li M, Hu L, Kataoka T. | 01/21/2010 |
| Phospholipase Cepsilon has a role in Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation | Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation.
Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH., Free PMC Article | 01/21/2010 |