| ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons. | ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.
Klickstein JA, Johnson MA, Antonoudiou P, Maguire J, Paulo JA, Gygi SP, Weihl C, Raman M., Free PMC Article | 03/21/2024 |
| Bone scan findings of Paget's disease of bone in patients with VCP Multisystem Proteinopathy 1. | Bone scan findings of Paget's disease of bone in patients with VCP Multisystem Proteinopathy 1.
Columbres RCA, Din S, Gibbs L, Kimonis V., Free PMC Article | 03/14/2024 |
| Proteomics analysis of serum and urine identifies VCP and CTSA as potential biomarkers associated with multiple myeloma. | Proteomics analysis of serum and urine identifies VCP and CTSA as potential biomarkers associated with multiple myeloma.
Fu W, Song Y, Zhao R, Zhao J, Yue Y, Zhang R. | 12/27/2023 |
| Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group. | Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group.
Hoff FW, Qiu Y, Brown BD, Gerbing RB, Leonti AR, Ries RE, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, Jenkins GN, Horton TM, Kornblau SM., | 12/1/2023 |
| p97/VCP Promotes the Recycling of Endocytic Cargo. | p97/VCP Promotes the Recycling of Endocytic Cargo.
Kawan M, Körner M, Schlosser A, Buchberger A., Free PMC Article | 11/22/2023 |
| An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP. | An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP.
Mah-Som AY, Daw J, Huynh D, Wu M, Creekmore BC, Burns W, Skinner SA, Holla ØL, Smeland MF, Planes M, Uguen K, Redon S, Bierhals T, Scholz T, Denecke J, Mensah MA, Sczakiel HL, Tichy H, Verheyen S, Blatterer J, Schreiner E, Thies J, Lam C, Spaeth CG, Pena L, Ramsey K, Narayanan V, Seaver LH, Rodriguez D, Afenjar A, Burglen L, Lee EB, Chou TF, Weihl CC, Shinawi MS., | 11/8/2023 |
| The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. | The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP.
Körner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A., Free PMC Article | 10/11/2023 |
| Nuclear VCP drives colorectal cancer progression by promoting fatty acid oxidation. | Nuclear VCP drives colorectal cancer progression by promoting fatty acid oxidation.
Huang Y, Wang F, Lin X, Li Q, Lu Y, Zhang J, Shen X, Tan J, Qin Z, Chen J, Chen X, Pan G, Wang X, Zeng Y, Yang S, Liu J, Xing F, Li K, Zhang H., Free PMC Article | 10/5/2023 |
| Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases. | Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases.
Chu S, Xie X, Payan C, Stochaj U., Free PMC Article | 08/9/2023 |
| Novel variants, muscle imaging, and myopathological changes in Chinese patients with VCP-related multisystem proteinopathy. | Novel variants, muscle imaging, and myopathological changes in Chinese patients with VCP-related multisystem proteinopathy.
Wan Y, Wang Q, Zheng Y, Yu M, Xie Z, Ling C, Meng L, Yu J, Zheng Y, Wang Y, Zhang W, Liu C, Zhao Y, Yuan Y, Deng J, Gang Q, Wang Z., Free PMC Article | 07/13/2023 |
| A Determination of p97/VCP (Valosin Containing Protein) and SVIP (Small VCP Interacting Protein) Expression Patterns in Human Testis. | A Determination of p97/VCP (Valosin Containing Protein) and SVIP (Small VCP Interacting Protein) Expression Patterns in Human Testis.
Arıcı A, Erdemir F., Free PMC Article | 07/7/2023 |
| A novel VCP::TFE3 gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in TFE3 rearranged renal cancer cell carcinoma. | A novel VCP::TFE3 gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in TFE3 rearranged renal cancer cell carcinoma.
Kuentz MA, Blons H, Gimenez-Roqueplo AP, Just PA, Laurent-Puig P, Mejean A, Oudard S, Verkarre V. | 04/12/2023 |
| Novel Variants in the VCP Gene Causing Multisystem Proteinopathy 1. | Novel Variants in the VCP Gene Causing Multisystem Proteinopathy 1.
Columbres RCA, Chin Y, Pratti S, Quinn C, Gonzalez-Cuyar LF, Weiss M, Quintero-Rivera F, Kimonis V., Free PMC Article | 03/30/2023 |
| The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA. | The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.
Jaffray EG, Tatham MH, Mojsa B, Liczmanska M, Rojas-Fernandez A, Yin Y, Ball G, Hay RT., Free PMC Article | 03/8/2023 |
| In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor. | In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
Mirzadeh A, Kobakhidze G, Vuillemot R, Jonic S, Rouiller I., Free PMC Article | 10/1/2022 |
| Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase. | Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.
Fujisawa R, Polo Rivera C, Labib KPM., Free PMC Article | 08/20/2022 |
| Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. | Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Bürli RW, Rubinsztein DC., Free PMC Article | 07/30/2022 |
| A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy. | A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy.
Shmara A, Perez-Rosendahl M, Murphy K, Kwon A, Smith C, Kimonis V., Free PMC Article | 07/30/2022 |
| Multisystem Proteinopathy Due to VCP Mutations: A Review of Clinical Heterogeneity and Genetic Diagnosis. | Multisystem Proteinopathy Due to VCP Mutations: A Review of Clinical Heterogeneity and Genetic Diagnosis.
Pfeffer G, Lee G, Pontifex CS, Fanganiello RD, Peck A, Weihl CC, Kimonis V., Free PMC Article | 07/2/2022 |
| Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN. | Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN.
Kröning A, van den Boom J, Kracht M, Kueck AF, Meyer H., Free PMC Article | 07/2/2022 |
| p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells. | p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells.
Prophet SM, Naughton BS, Schlieker C., Free PMC Article | 05/28/2022 |
| VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway. | VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, Fan X., Free PMC Article | 05/21/2022 |
| p97 dysfunction underlies a loss of quality control of damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease. | p97 dysfunction underlies a loss of quality control of damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease.
Song A, Wen AQ, Wen YE, Dzieciatkowska M, Kellems RE, Juneja HS, D'Alessandro A, Xia Y. | 04/30/2022 |
| VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells. | VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells.
Szczęśniak PP, Heidelberger JB, Serve H, Beli P, Wagner SA., Free PMC Article | 04/30/2022 |
| Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP. | Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP.
Wani A, Weihl CC., Free PMC Article | 04/16/2022 |