| RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H. | RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
Zhang S, Bao Y, Shen X, Pan Y, Sun Y, Xiao M, Chen K, Wei H, Zuo J, Saffen D, Zong WX, Sun Y, Wang Z, Wang Y., Free PMC Article | 08/7/2021 |
| eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated amyotrophic lateral sclerosis. | eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.
Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM., Free PMC Article | 04/25/2020 |
| The results from these procedures revealed eIF4H to be one of the targets of miR-519d. Downregulated eIF4H was analogous to the overexpressed miR-519d obtained from miR-519d agomir and si-eIF4H transfection. In summary, it can be concluded that miR-519d targets eIF4H in lung adenocarcinoma to inhibit cell proliferation and invasion | Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.
Bai Y, Lu C, Zhang G, Hou Y, Guo Y, Zhou H, Ma X, Zhao G. | 04/8/2017 |
| Results demonstrate that eukaryotic translation initiation factor 4H (eIF4H) plays a crucial role in translational control. | Key contribution of eIF4H-mediated translational control in tumor promotion.
Vaysse C, Philippe C, Martineau Y, Quelen C, Hieblot C, Renaud C, Nicaise Y, Desquesnes A, Pannese M, Filleron T, Escourrou G, Lawson M, Rintoul RC, Delisle MB, Pyronnet S, Brousset P, Prats H, Touriol C., Free PMC Article | 09/24/2016 |
| Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-kappaB. | Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.
Fiume G, Rossi A, de Laurentiis A, Falcone C, Pisano A, Vecchio E, Pontoriero M, Scala I, Scialdone A, Masci FF, Mimmi S, Palmieri C, Scala G, Quinto I., Free PMC Article | 01/18/2014 |
| Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR. | mRNA helicases: the tacticians of translational control.
Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N. | 06/18/2011 |
| results suggest that eIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy | An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer.
Wu D, Matsushita K, Matsubara H, Nomura F, Tomonaga T. | 02/5/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articles | 12/2/2009 |
| Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. | Uncoupling stress granule assembly and translation initiation inhibition.
Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R., Free PMC Article | 01/21/2010 |
| Study reports the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. | Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.
Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G., Free PMC Article | 01/21/2010 |
| The interaction of eIF4AI with two accessory factors, eIF4B and eIF4H, was studied. | Interactions between eIF4AI and its accessory factors eIF4B and eIF4H.
Rozovsky N, Butterworth AC, Moore MJ., Free PMC Article | 01/21/2010 |
| eIF4H binding is required for herpes simplex virus virion host shutoff-induced degradation of many mRNAs, perhaps by targeting Vhs to mRNAs and to preferred sites within mRNAs. | Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus.
Sarma N, Agarwal D, Shiflett LA, Read GS., Free PMC Article | 01/21/2010 |
| data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES | Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H.
Doepker RC, Hsu WL, Saffran HA, Smiley JR., Free PMC Article | 01/21/2010 |