| Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway. | Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway.
Ma G, Zhang B, Fu S, Lu J, Zhang L, Shang P, Yue Z. | 09/20/2023 |
| miR-143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings. | miR-143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings.
Cui F, Ji Y, Wang M, Gao F, Li Y, Li X. | 09/5/2020 |
| The carboxy-terminus of the formin FMNL1 bundles actin to potentiate adenocarcinoma migration. | The carboxy-terminus of the formin FMNL1ɣ bundles actin to potentiate adenocarcinoma migration.
Miller EW, Blystone SD. | 08/22/2020 |
| Formin-like 1 protein (FMNL1) is a promising therapeutic target for glioblastoma multiforme (GBM) progression. | Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis.
Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K., Free PMC Article | 05/9/2020 |
| Suppressing FMNL1 expression could inhibit bone metastasis in NSCLC through blocking TGF-beta1 signaling. | FMNL1 down-regulation suppresses bone metastasis through reducing TGF-β1 expression in non-small cell lung cancer (NSCLC).
Yang XY, Liao JJ, Xue WR. | 01/18/2020 |
| Results indicated that FMNL1 is a susceptibility gene for leprosy. | A pathway-based association analysis identified FMNL1-MAP3K14 as susceptibility genes for leprosy.
Zhang H, Wang Z, Fu X, Sun Y, Mi Z, Yu G, Sun L, Wang N, Wang C, Zhao Q, Pan Q, Yue Z, Liu H, Zhang F. | 03/23/2019 |
| High expression of FMNL1, resulted from decreased miR-16 and/or MTA1 amplification. | FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1.
Chen WH, Cai MY, Zhang JX, Wang FW, Tang LQ, Liao YJ, Jin XH, Wang CY, Guo L, Jiang YG, Ren CP, Mai HQ, Zeng MS, Kung HF, Qian CN, Xie D. | 02/23/2019 |
| FMNL1 contributes to leukemogenesis and could act in part through Rac1 regulation. | FMNL1 promotes proliferation and migration of leukemia cells.
Favaro P, Traina F, Machado-Neto JA, Lazarini M, Lopes MR, Pereira JK, Costa FF, Infante E, Ridley AJ, Saad ST. | 11/16/2013 |
| constitutively activated form of FMNL1 (FMNL1gamma) induces localization of AHNAK1 to the cell membrane. | Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.
Han Y, Yu G, Sarioglu H, Caballero-Martinez A, Schlott F, Ueffing M, Haase H, Peschel C, Krackhardt AM. | 07/6/2013 |
| Results suggest that macrophage coiling phagocytosis is a complex process involving several actin nucleation/regulatory factors. They also point specifically to the formins mDia1 and FMNL1 as novel regulators of spirochete uptake by human immune cells. | The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophages.
Naj X, Hoffmann AK, Himmel M, Linder S., Free PMC Article | 06/22/2013 |
| after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics. | Bi-modal regulation of a formin by srGAP2.
Mason FM, Heimsath EG, Higgs HN, Soderling SH., Free PMC Article | 04/16/2011 |
| Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues. | The formin FRL1 (FMNL1) is an essential component of macrophage podosomes.
Mersich AT, Miller MR, Chkourko H, Blystone SD., Free PMC Article | 01/1/2011 |
| Results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells. | Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.
Han Y, Eppinger E, Schuster IG, Weigand LU, Liang X, Kremmer E, Peschel C, Krackhardt AM., Free PMC Article | 01/25/2010 |
| Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies, cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. | Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt.
Favaro PM, de Souza Medina S, Traina F, Bassères DS, Costa FF, Saad ST. | 01/21/2010 |