| Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma. | Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.
Pan J, Zhang M, Dong L, Ji S, Zhang J, Zhang S, Lin Y, Wang X, Ding Z, Qiu S, Gao D, Zhou J, Fan J, Gao Q., Free PMC Article | 03/13/2023 |
| LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/betacatenin pathway. | LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.
Han S, Jin X, Hu T, Chi F., Free PMC Article | 02/22/2023 |
| LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. | LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.
Wang Y, Liu J, Akatsu C, Zhang R, Zhang H, Zhu H, Liu K, Zhu HY, Min Q, Meng X, Cui C, Tang Y, Yu M, Li Y, Feng X, Wei H, Wen Z, Ji S, Weigert MG, Tsubata T, Wang JY., Free PMC Article | 09/3/2022 |
| Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation. | Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
Jiang B, Zhao X, Chen W, Diao W, Ding M, Qin H, Li B, Cao W, Chen W, Fu Y, He K, Gao J, Chen M, Lin T, Deng Y, Yan C, Guo H., Free PMC Article | 07/30/2022 |
| LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr. | LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr.
Ouyang J, Xiong Y, Shang H, Liang G., Free PMC Article | 05/14/2022 |
| Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. | Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy.
Li T, Wang W, Gan W, Lv S, Zeng Z, Hou Y, Yan Z, Zhang R, Yang M., Free PMC Article | 04/23/2022 |
| Spinespecific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptorpositive breast cancer by activating glutaminedependent mTOR signaling. | Spine‑specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor‑positive breast cancer by activating glutamine‑dependent mTOR signaling.
Meng Q, Zhou L, Liang H, Hu A, Zhou H, Zhou J, Zhou X, Lin H, Li X, Jiang L, Dong J., Free PMC Article | 03/26/2022 |
| LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. | LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival.
Yang X, Wen Y, Liu S, Duan L, Liu T, Tong Z, Wang Z, Gu Y, Xi Y, Wang X, Luo D, Zhang R, Liu Y, Wang Y, Cheng T, Jiang S, Zhu X, Yang X, Pan Y, Cheng S, Ye Q, Chen J, Xu X, Gao S., Free PMC Article | 02/26/2022 |
| Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages. | Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Zhao L, Wang S, Xu M, He Y, Zhang X, Xiong Y, Sun H, Ding H, Geng W, Shang H, Liang G., Free PMC Article | 07/10/2021 |
| These findings suggest that the inactivation of LAPTM5 may contribute to tumorigenesis in a subset of human cancers | Down-regulation of LAPTM5 in human cancer cells.
Nuylan M, Kawano T, Inazawa J, Inoue J., Free PMC Article | 12/16/2017 |
| Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells | Downregulation of LAPTM5 suppresses cell proliferation and viability inducing cell cycle arrest at G0/G1 phase of bladder cancer cells.
Chen L, Wang G, Luo Y, Wang Y, Xie C, Jiang W, Xiao Y, Qian G, Wang X. | 04/8/2017 |
| Insufficient expression of LAPTM5 may take part in the pathogenesis of systemic lupus erythematosus (SLE) and contribute to the severity of the disease, none of LAPTM5 polymorphisms contributes significantly to SLE susceptibility in a Chinese population. | Expression and Polymorphisms of Lysosome-Associated Protein Transmembrane 5 (LAPTM5) in Patients with Systemic Lupus Erythematosus in a Chinese Population.
Cai X, Qiao Y, Chen Y, Du S, Chen D, Yu S, Liu N, Jiang Y. | 01/2/2016 |
| The interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens. | Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e.
Angénieux C, Waharte F, Gidon A, Signorino-Gelo F, Wurtz V, Hojeij R, Proamer F, Gachet C, Van Dorsselaer A, Hanau D, Salamero J, de la Salle H., Free PMC Article | 01/12/2013 |
| LAPTM5 is a substrate of the ITCH-mediated degradation and its protein level is negatively regulated by ITCH | HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.
Ishihara T, Inoue J, Kozaki KI, Imoto I, Inazawa J., Free PMC Article | 02/25/2012 |
| LAPTM5-mediated programmed cell death is closely associated with the spontaneous regression of neuroblastomas | Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.
Inoue J, Misawa A, Tanaka Y, Ichinose S, Sugino Y, Hosoi H, Sugimoto T, Imoto I, Inazawa J., Free PMC Article | 02/8/2010 |
| results suggest that loss of E3 gene expression might be a crucial event during the progression of human MM | Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
Hayami Y, Iida S, Nakazawa N, Hanamura I, Kato M, Komatsu H, Miura I, Dave BJ, Sanger WG, Lim B, Taniwaki M, Ueda R. | 01/21/2010 |
| LAPTM5 shows stage-specific expression during B cell differentiation. It may be involved in B cell malignancies. | Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas.
Seimiya M, O-Wang J, Bahar R, Kawamura K, Wang Y, Saisho H, Tagawa M. | 01/21/2010 |