| Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein. | Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.
Kretz PF, Wagner C, Mikhaleva A, Montillot C, Hugel S, Morella I, Kannan M, Fischer MC, Milhau M, Yalcin I, Brambilla R, Selloum M, Herault Y, Reymond A, Collins SC, Yalcin B., Free PMC Article | 11/28/2023 |
| Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. | Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts.
Wang R, Yang Y, Zhang Z, Zhao N, Wiemer EAC, Ben J, Ma J, Yuan L., Free PMC Article | 09/19/2023 |
| Macrophage MVP regulates fracture repair by promoting M2 polarization via JAK2-STAT6 pathway. | Macrophage MVP regulates fracture repair by promoting M2 polarization via JAK2-STAT6 pathway.
Yang Y, Zhao N, Wang R, Zhan Z, Guo S, Song H, Wiemer EAC, Ben J, Ma J. | 06/24/2023 |
| Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling. | Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.
Liu Q, Pan J, Bao L, Xu C, Qi Y, Jiang B, Wang D, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Ben J, Chen Q. | 05/7/2022 |
| Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. | Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition.
Yuan L, Zhao N, Wang J, Liu Y, Meng L, Guo S, Wiemer EAC, Chen Q, Mao Y, Ben J, Ma J., Free PMC Article | 07/31/2021 |
| MVP regulates activity-dependent synaptic plasticity in mouse visual cortex. | Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity.
Ip JPK, Nagakura I, Petravicz J, Li K, Wiemer EAC, Sur M., Free PMC Article | 10/5/2019 |
| Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis in mice. Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases. | Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, Tong X, Chen L, Liu X, Zhang Y, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Xu Y, Chen Q., Free PMC Article | 05/25/2019 |
| plays major role in anti-viral immunity | Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response.
Peng N, Liu S, Xia Z, Ren S, Feng J, Jing M, Gao X, Wiemer EA, Zhu Y. | 08/20/2016 |
| MVP may fine-tune SR-A activity in macrophages which contributes to the development of atherosclerosis | Major vault protein regulates class A scavenger receptor-mediated tumor necrosis factor-α synthesis and apoptosis in macrophages.
Ben J, Zhang Y, Zhou R, Zhang H, Zhu X, Li X, Zhang H, Li N, Zhou X, Bai H, Yang Q, Li D, Xu Y, Chen Q., Free PMC Article | 09/14/2013 |
| MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles. | Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.
Dortet L, Mostowy S, Samba-Louaka A, Gouin E, Nahori MA, Wiemer EA, Dussurget O, Cossart P., Free PMC Article | 12/3/2011 |
| The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH. | The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Querol-Audí J, Casañas A, Usón I, Luque D, Castón JR, Fita I, Verdaguer N., Free PMC Article | 01/21/2010 |
| Results suggest that major vault protein functions as a novel scaffold protein for both SHP-2 and Erk. | The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.
Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM. | 01/21/2010 |
| results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection | Host resistance to lung infection mediated by major vault protein in epithelial cells.
Kowalski MP, Dubouix-Bourandy A, Bajmoczi M, Golan DE, Zaidi T, Coutinho-Sledge YS, Gygi MP, Gygi SP, Wiemer EA, Pier GB., Free PMC Article | 01/21/2010 |
| These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling. | Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP.
Emre N, Raval-Fernandes S, Kickhoefer VA, Rome LH. | 01/21/2010 |