| PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway. | PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway.
Bai L, Yang J, Zhang H, Liao W, Cen Y., Free PMC Article | 12/11/2021 |
| CARD9 protects cardiomyocytes from apoptosis by interacting with Apaf-1 and interfering with apoptosome formation following myocardial ischemia/reperfusion injury in vivo and in vitro | CARD9 inhibits mitochondria-dependent apoptosis of cardiomyocytes under oxidative stress via interacting with Apaf-1.
Li Y, Liang P, Jiang B, Tang Y, Lv Q, Hao H, Liu Z, Xiao X. | 07/18/2020 |
| ZYZ-488 as a novel small molecule competitive inhibitor of Apaf-1, with the great potential for treating cardiac ischemia. | The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification.
Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ., Free PMC Article | 06/2/2018 |
| miR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing. | microRNA-183 Mediates Protective Postconditioning of the Liver by Repressing Apaf-1.
Lin HC, Liu SY, Yen EY, Li TK, Lai IR. | 08/12/2017 |
| MicroRNA-17-mediated down-regulation of Apaf-1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. | MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes.
Song S, Seo HH, Lee SY, Lee CY, Lee J, Yoo KJ, Yoon C, Choi E, Hwang KC, Lee S. | 11/14/2015 |
| results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases. | Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.
Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero JG, Landeta O, Basañez G, Carbajo RJ, Pineda-Lucena A, Bujons J, Moure A, Messeguer A, Lagunas C, Herrero C, Pérez-Payá E., Free PMC Article | 07/4/2015 |
| Chronic hyperglycemia exacerbated apoptosis and exaggerated loss of cytosolic and mitochondrial redox balance, impaired G6PD activity, and enhanced expression of Apaf-1. | Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression.
Okouchi M, Okayama N, Aw TY. | 01/21/2010 |
| erythropoietin maintains both genomic DNA integrity and cellular membrane asymmetry through parallel pathways that prevent the induction of Apaf-1 and preserve mitochondrial membrane potential in conjunction with enhanced Bcl-XL expression | Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin.
Chong ZZ, Kang JQ, Maiese K. | 01/21/2010 |
| Results show that nPC12 transition to dPC12 cells afforded protection against oxidative challenge due to maintenance of reduced GSH/GSSG and decreased Apaf-1 expression. | Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1.
Ekshyyan O, Aw TY. | 01/21/2010 |
| The subcellular distribution of the apoptosome scaffold protein apoptotic protease-activating factor 1 (Apaf-1) before and after triggering apoptosis in single somatotrophs is reported. | Subcellular localization of Apaf-1 in apoptotic rat pituitary cells.
Potokar M, Kreft M, Chowdhury HH, Vardjan N, Zorec R. | 01/21/2010 |
| Alteration of apoptotic protease-activating factor-1 (APAF-1)-dependent apoptotic pathway during development of rat brain and liver. "APAF-1" | Alteration of apoptotic protease-activating factor-1 (APAF-1)-dependent apoptotic pathway during development of rat brain and liver.
Ota K, Yakovlev AG, Itaya A, Kameoka M, Tanaka Y, Yoshihara K. | 01/21/2010 |