| Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress. | Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress.
Fan J, Liu M, Li X, Gao S, Wang Y, Li A, Chen L, Zhou D, Chen H, Xu Z, Wu Z, Wu K. | 02/28/2023 |
| Our findings provide an insight into the PTEN and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury, which may be through inducing the PINK1/Parkin-mediated mitophagy. | PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury.
Tang W, Lin D, Chen M, Li Z, Zhang W, Hu W, Li F. | 03/7/2020 |
| Changes in APE1 expression and sub-cellular distribution are implicated in inflammatory pain mechanisms mediated by APE1 redox functions. | APE1/Ref-1 redox function contributes to inflammatory pain sensitization.
Zaky A, Bouali-Benazzouz R, Favereaux A, Tell G, Landry M. | 02/23/2019 |
| Study shows that genetically enhancing apurinic/apyrimidinic endonuclease expression or treatment with the small molecule, E3330, increases DNA repair. | DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.
Fehrenbacher JC, Guo C, Kelley MR, Vasko MR., Free PMC Article | 06/30/2018 |
| Our findings provided valuable insights into the redox function of APE1/Ref-1 in preventing Pi-induced VSMC calcification by inhibiting oxidative stress and osteoblastic differentiation, resulting in prevention of altered osteoblastic phenotypes in VSMCs. | APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
Lee KM, Lee EO, Lee YR, Joo HK, Park MS, Kim CS, Choi S, Jeong JO, Jeon BH., Free PMC Article | 05/26/2018 |
| The results of this study suggest that Ape1 protects against neuron death by activating the ERK1/2 signaling pathway. | Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells.
Kang B, Mu S, Yang Q, Guo S, Chen X, Guo H. | 01/13/2018 |
| altered expression and/or subcellular distribution of APE1/Ref-1 in activated astrocytes regulated the neuroinflammatory response to excitotoxin and endotoxin insults used in model of neurodegenerative brain diseases. | The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Baek H, Lim CS, Byun HS, Cho HS, Lee YR, Shin YS, Kim HW, Jeon BH, Kim DW, Hong J, Hur GM, Park JB., Free PMC Article | 11/11/2017 |
| This study suggests that a new function of GLP-1 is to elevate DNA repair by inducing the expression of the DNA repair protein APE1. | Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1.
Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD., Free PMC Article | 10/21/2017 |
| In summary, APE1 is regulated at different levels after acute and chronic UUO. Thus, our results suggest that DNA repair activity is regulated in response to progressive (7 days) obstruction and that APE1 potentially could play a role in the development of fibrosis in kidney disease. | Unilateral ureteral obstruction induces DNA repair by APE1.
Aamann MD, Nørregaard R, Kristensen ML, Stevnsner T, Frøkiær J. | 07/1/2017 |
| Ape1 expression was initially high and then gradually reduced along with the tooth development. | Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells.
Chen T, Liu Z, Sun W, Li J, Liang Y, Yang X, Xu Y, Yu M, Tian W, Chen G, Bai D., Free PMC Article | 10/22/2016 |
| these data provide the first evidence that a critical BER enzyme, APE1, helps regulate the NER pathway in the repair of cisplatin damage in sensory neurons. | APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER.
Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH., Free PMC Article | 11/28/2015 |
| BDNF stimulates DNA repair by activating CREB, which, in turn, induces the expression of APE1. Suppression of either APE1 or TrkB by RNA interference abolishes the ability of BDNF to protect neurons against oxidized DNA damage-induced death. | BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.
Yang JL, Lin YT, Chuang PC, Bohr VA, Mattson MP., Free PMC Article | 11/8/2014 |
| a unique redox modification of APE1 protein and consequent loss of its activity seem to play a crucial role in increased apurinic/apyrimidinic-site accumulation and eventually liver carcinogenesis. | Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.
Karmahapatra SK, Saha T, Adhikari S, Woodrick J, Roy R., Free PMC Article | 10/25/2014 |
| In an experimental condition preceding tumorigenesis, APE1 contributes to the repair of oxidative DNA lesions in the spleen. | Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure.
Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF., Free PMC Article | 05/4/2013 |
| Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation. | Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.
Hashimoto S, Imaoka S., Free PMC Article | 03/30/2013 |
| p53-dependent apoptosis resulting in suppressed apurinic-apyrimidinic endonuclease might be an underlying mechanism of diabtic nephropathy. | The role of apurinic/apyrimidinic endonuclease on the progression of streptozotocin-induced diabetic nephropathy in rats.
Kim JN, Chang IY, Kim JH, Kim JW, Park KS, Kim HI, Yoon SP. | 11/3/2012 |
| Modulation of AP-endonuclease1 levels associated with hepatic cirrhosis in rat model treated with human umbilical cord blood mononuclear stem cells. | Modulation of AP-endonuclease1 levels associated with hepatic cirrhosis in rat model treated with human umbilical cord blood mononuclear stem cells.
Bassiouny AR, Zaky AZ, Abdulmalek SA, Kandeel KM, Ismail A, Moftah M., Free PMC Article | 03/3/2012 |
| the repair function of APE1 is required to protect both hippocampal and DRG neuronal cultures--specifically neuronal cells--from IR-induced damage, while the redox activity of APE1 does not appear to be involved. | The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.
Vasko MR, Guo C, Thompson EL, Kelley MR., Free PMC Article | 12/24/2011 |
| Conclude that curcumin reduced markers of liver damage in rats treated with CCl4, with concomitant elevation in AP-endonuclease1 protein level indicating a possible protective effect with unknown mechanism. | Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats.
Bassiouny AR, Zaky A, Kandeel KM. | 11/26/2011 |
| After the administration of paraquat, the levels of PUMA, cleaved caspase-3, and APE increased in a time-dependent manner, indicating that PQ-induced nephrotoxicity was caused by activation of the apoptotic pathway. | Protective effects of chitosan oligosaccharide on paraquat-induced nephrotoxicity in rats.
Yoon SP, Han MS, Kim JW, Chang IY, Kim HL, Chung JH, Shin BC. | 10/1/2011 |
| The immunolocalization of 8-oxoguanine DNA glycosylase 1 (OGG1) and AP endonuclease 1 (APE1) in the lens and three of the predominant base excision repair (BER) enzymes: OGG1, APE1, and DNA polymerase gamma, were studied. | Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens.
Zhang Y, Zhang L, Zhang L, Bai J, Ge H, Liu P., Free PMC Article | 11/13/2010 |
| DNA damage that is rapidly repaired by a mechanism involving Ca(2+)-induced, CREB-mediated APE1 expression | Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.
Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA., Free PMC Article | 10/23/2010 |
| Ref-1 expression increased in the after hippocampus CA1 area after induction of Alzheimer's disease. | [Expression of Ref-1 in hippocampus CA1 area of rats with Alzheimer's disease].
Wu HQ, Yao L, Du Y, Zhang GL, Zhang R, Liu JJ, Pu N. | 04/12/2010 |
| Data show that the rabbit anti-human APE1 polyclonal antibody with high titer and specificity can be used not only to elucidate the roles of APE1 protein in cellular procedures, but also to detect the expression of the APE1 protein in mice and rats. | [Preparation and characterization of rabbit anti-human apurinic/apyrimidinic endonuclease(APE1) polyclonal antibody].
Cao XJ, Dai N, Yi WJ, Li ZP, Yang YX, Wang D, Hu CM. | 03/15/2010 |
| increased expression in liver transplanted group | Expression of redox factor-1 in early injury period after liver transplantation in rat model.
Zhang P, Du X, Sun Z, Xu L., Free PMC Article | 03/1/2010 |