Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1. | Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1. You H, Wen X, Wang X, Zhu C, Chen H, Bu L, Zhang J, Qu S. | 10/4/2023 |
Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22(phox) by thiol modification. | Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22(phox) by thiol modification. Miyano K, Okamoto S, Kajikawa M, Kiyohara T, Kawai C, Yamauchi A, Kuribayashi F., Free PMC Article | 10/8/2022 |
Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis. | Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis. Wei JY, Zhang Q, Yao Y, He HB, Sun CH, Dong TT, Meng GP, Zhang J. | 10/1/2022 |
The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1. | The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1. Rao B, Li S, Yao D, Wang Q, Xia Y, Jia Y, Shen Y, Cao Y., Free PMC Article | 04/23/2022 |
Derlin-1, as a Potential Early Predictive Biomarker for Nonresponse to Infliximab Treatment in Rheumatoid Arthritis, Is Related to Autophagy. | Derlin-1, as a Potential Early Predictive Biomarker for Nonresponse to Infliximab Treatment in Rheumatoid Arthritis, Is Related to Autophagy. Cai Y, Xu K, Aihaiti Y, Li Z, Yuan Q, Xu J, Zheng H, Yang M, Wang B, Yang Y, Yang Y, Xu P., Free PMC Article | 02/19/2022 |
Derlin-1 functions as a growth promoter in breast cancer. | Derlin-1 functions as a growth promoter in breast cancer. Liu Y, Wang Z, Liu H, Wang X, Zhang Z, Xiao B, An B, Zhang J. | 04/13/2021 |
Derlin-1 exhibits oncogenic activities and indicates an unfavorable prognosis in breast cancer. | Derlin-1 exhibits oncogenic activities and indicates an unfavorable prognosis in breast cancer. Zeng J, Tian Q, Zeng Z, Cai J, Ye M, Liu Y, Liu A. | 10/3/2020 |
association of the degradation factor HRD1 with the translocon and the rerouting factor Derlin-1 may be necessary for the smooth and effective clearance of ERpQC substrates | Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Kadowaki H, Satrimafitrah P, Takami Y, Nishitoh H., Free PMC Article | 10/12/2019 |
Overexpression of Derlin-1 is Associated with Non-small Cell Lung Cancer. | Overexpression of Derlin-1 is Associated with Poor Prognosis in Patients with Non-small Cell Lung Cancer. Mao M, Zhang J, Jiang J. | 09/22/2018 |
These findings for the first time revealed that miR-598, as a tumor suppressor, negatively regulate DERL1 and Epithelial-Mesenchymal Transition to suppress the invasion and migration in Non-Small Cell Lung Cancer (NSCLC), thereby putatively serving as a novel therapeutic target for NSCLC clinical treatment. | MiR-598 Suppresses Invasion and Migration by Negative Regulation of Derlin-1 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Yang F, Wei K, Qin Z, Liu W, Shao C, Wang C, Ma L, Xie M, Shu Y, Shen H. | 08/25/2018 |
ChIP assays were used to ascertain the correlations between HNF1beta and Derlin-1 in the miR-217/HNF1beta/Derlin-1 pathway in glioma cells | TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway. Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z, Liu Y., Free PMC Article | 12/16/2017 |
The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC. You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X. | 08/12/2017 |
Derlin-1 is overexpressed in bladder cancer and promotes malignant phenotype through ERK/MMP-2/9 and PI3K/AKT signaling pathway. | Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling. Dong Q, Fu L, Zhao Y, Tan S, Wang E., Free PMC Article | 08/5/2017 |
Derlin-1 was overexpressed in bladder cancer and was associated with the malignancy of bladder cancer. | High Expression of Derlin-1 Is Associated with the Malignancy of Bladder Cancer in a Chinese Han Population. Wu Z, Wang C, Zhang Z, Liu W, Xu H, Wang H, Wang Y, Zhang W, Wang SL., Free PMC Article | 07/8/2017 |
insights into the interactions between other SHP-containing proteins and p97N | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. Lim JJ, Lee Y, Yoon SY, Ly TT, Kang JY, Youn HS, An JY, Lee JG, Park KR, Kim TG, Yang JK, Jun Y, Eom SH. | 05/13/2017 |
data suggest that miR-181d is a tumor suppressor in ESCC inversely regulating its downstream target gene of DERL1. | MicroRNA-181d is a tumor suppressor in human esophageal squamous cell carcinoma inversely regulating Derlin-1. Li D, Shi M, Ji H, Chen G, Jiang H, Wang Z. | 03/4/2017 |
Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells. | Derlin-1 is overexpressed in human colon cancer and promotes cancer cell proliferation. Tan X, He X, Jiang Z, Wang X, Ma L, Liu L, Wang X, Fan Z, Su D. | 07/16/2016 |
TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1. | TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ., Free PMC Article | 10/4/2014 |
Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation. | Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. Chen SF, Wu CH, Lee YM, Tam K, Tsai YC, Liou JY, Shyue SK., Free PMC Article | 01/25/2014 |
Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. | Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. Dong QZ, Wang Y, Tang ZP, Fu L, Li QC, Wang ED, Wang EH. | 08/10/2013 |
Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease. | Derlin-1-immunopositive inclusions in patients with Alzheimer's disease. Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K. | 04/6/2013 |
These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively. | Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T., Free PMC Article | 07/28/2012 |
Derlin-1 expression levels may affect glucose-stimulated insulin secretion by altering surface expression of K(ATP) channels. | Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels. Wang F, Olson EM, Shyng SL., Free PMC Article | 05/19/2012 |
Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression and provide a novel posttranslational regulatory mechanism of BCRP by Derlin-1. | Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1. Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H., Free PMC Article | 03/12/2011 |
Derlin-1 did not modify KCNQ1 expression level, and no interaction between endogenous KCNQ1 and Derlin-1 could be detected. | LQT1-associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1. Peroz D, Dahimène S, Baró I, Loussouarn G, Mérot J. | 01/21/2010 |