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    TBL1XR1 TBL1X/Y related 1 [ Homo sapiens (human) ]

    Gene ID: 79718, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The spectrum of neurological presentation in individuals affected by TBL1XR1 gene defects.

    The spectrum of neurological presentation in individuals affected by TBL1XR1 gene defects.
    Nagy A, Molay F, Hargadon S, Brito Pires C, Grant N, De La Rosa Abreu L, Chen JY, D'Souza P, Macnamara E, Tifft C, Becker C, Melo De Gusmao C, Khurana V, Neumeyer AM, Eichler FS., Free PMC Article

    02/23/2024
    lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the Epithelial-Mesenchymal Transition of Cervical Cancer Cells.

    lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the Epithelial-Mesenchymal Transition of Cervical Cancer Cells.
    Liao L, Huang P, Zhao J, Wang Z, Chen H, Zhang C, Huang L.

    12/20/2023
    Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.

    Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.
    Mansoor A, Akhter A, Hamidi M, Roshan TM, Shabani-Rad MT, Stewart D.

    11/3/2023
    Expanding the genotypic and phenotypic spectrum associated with TBL1XR1 de novo variants.

    Expanding the genotypic and phenotypic spectrum associated with TBL1XR1 de novo variants.
    Ren M, Zheng H, Lu X, Lian W, Feng B.

    09/22/2023
    TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.

    TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.
    Pray BA, Youssef Y, Alinari L., Free PMC Article

    12/17/2022
    Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis.

    Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis.
    Cheng S, Chen C, Wang L.

    08/20/2022
    TBL1XR1 associated intellectual disability, a new missense variant with dysmorphic features plus autism: Expanding the phenotypic spectrum.

    TBL1XR1 associated intellectual disability, a new missense variant with dysmorphic features plus autism: Expanding the phenotypic spectrum.
    Arroyo Carrera I, Fernández-Burriel M, Lapunzina P, Tenorio JA, García Navas VD, Márquez Isidro E.

    02/19/2022
    MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1.

    MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1.
    Pan Q, Shao Z, Zhang Y, Liu H.

    01/1/2022
    A novel fusion protein TBLR1-RARalpha acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies.

    A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies.
    Li S, Yang X, Liu S, Chen Y, Xing H, Tang K, Tian Z, Xu Y, Rao Q, Wang M, Wang J., Free PMC Article

    11/6/2021
    TBL1XR1 Mutations in Primary Marginal Zone Lymphomas of Ocular Adnexa are Associated with Unique Morphometric Phenotypes.

    TBL1XR1 Mutations in Primary Marginal Zone Lymphomas of Ocular Adnexa are Associated with Unique Morphometric Phenotypes.
    Jangam D, Sridhar K, Butzmann A, Samghabadi P, Plowey ED, Ohgami RS.

    10/16/2021
    Deficiency of TBL1XR1 causes asthenozoospermia.

    Deficiency of TBL1XR1 causes asthenozoospermia.
    Zhou Q, Xu M, Wang X, Yu M, Chen X, Lu J, Zhou R, Zhang J, Ling X, Ji J.

    08/7/2021
    Exosomal miR-103a-3p ameliorates lipopolysaccharide-induced immune response in BEAS-2B cells via NF-kappaB pathway by targeting transducin beta-like 1X related protein 1.

    Exosomal miR-103a-3p ameliorates lipopolysaccharide-induced immune response in BEAS-2B cells via NF-κB pathway by targeting transducin β-like 1X related protein 1.
    Li R, Liang P, Yuan J, He F.

    07/17/2021
    TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma.

    TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma.
    Gu JF, Fu W, Qian HX, Gu WX, Zong Y, Chen Q, Lu L., Free PMC Article

    07/10/2021
    TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.

    TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.
    Zhang T, Liu C, Yu Y, Geng J, Meng Q, Xu S, Zhou F, Chen Y, Jin S, Shen J, Pan B, Meng F, Liu F.

    05/15/2021
    TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma.

    TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma.
    Ednersson SB, Stern M, Fagman H, Nilsson-Ehle H, Hasselblom S, Andersson PO.

    05/8/2021
    TBL1XR1 mutation is not associated with Rett syndrome.

    Current clinical evidence does not support a link between TBL1XR1 and Rett syndrome: Description of one patient with Rett features and a novel mutation in TBL1XR1, and a review of TBL1XR1 phenotypes.
    Zaghlula M, Glaze DG, Enns GM, Potocki L, Schwabe AL, Suter B.

    05/25/2019
    Taken together, our results provide new evidence that TBL1XR1 overexpression induces cancer stem cell-like phenotypes and tumorigenic capability of osteosarcoma and might represent a novel therapeutic target for its treatment.

    Overexpression of TBL1XR1 confers tumorigenic capability and promotes recurrence of osteosarcoma.
    Xi X, Wu Q, Bao Y, Lin M, Zhong X, Dai X, Lin H.

    05/4/2019
    Over-expression of miR-199 in gastric carcinoma is associated with the decreased ability of proliferation and migration of gastric carcinoma cells by targeting the 3' untranslated region of TBL1XR1.

    [Effect of MicroRNA-199 on Proliferation and Migration of Gastric Carcinoma Cells].
    Yan C, Zhang LH, Shan F, Li SX, Jia YN, Li ZY.

    04/6/2019
    miR-130a-3p suppressed aggressive phenotype of Gastric Cancer cells partially by direct targeting and decreasing TBL1XR1 and subsequent epithelial-mesenchymal transition process.

    MicroRNA-130a-3p suppresses cell migration and invasion by inhibition of TBL1XR1-mediated EMT in human gastric carcinoma.
    Wang S, Han H, Hu Y, Yang W, Lv Y, Wang L, Zhang L, Ji J.

    01/5/2019
    These results suggest that a de novo TBL1XR1 point mutation could alter Wnt/beta-catenin signaling activity. Further studies are required to clarify the involvement of TBL1XR1 mutations in neuropsychiatric conditions.

    De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.
    Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, Kato Y, Kinoshita M, Shimodera S, Ono S, Ochi S, Imamura A, Kurotaki N, Ueno SI, Iwata N, Fukui K, Imoto I, Kamiya A, Ohmori T., Free PMC Article

    12/22/2018
    High TBL1XR1 expression indicates poor disease-free survival of stage I-III colorectal cancer patients; beta-catenin signaling is critical for TBL1XR1-mediated colorectal cancer cells oncogenicity.

    Correlations between TBL1XR1 and recurrence of colorectal cancer.
    Liu H, Xu Y, Zhang Q, Li K, Wang D, Li S, Ning S, Yang H, Shi W, Liu Z, Chen Y., Free PMC Article

    11/10/2018
    emonstrated that TBL1XR1 can regulate the expression of vascular endothelial growth factor C and epithelial-mesenchymal transition proteins

    TBL1XR1 predicts isolated tumor cells and micrometastasis in patients with TNM stage I/II colorectal cancer.
    Liu H, Liu Z, Li K, Li S, Song L, Gong Z, Shi W, Yang H, Xu Y, Ning S, Ismail S, Chen Y.

    03/3/2018
    Targeted SUMOylation of TBL1 and TBLR1 may be a useful strategy for therapeutic treatment of androgen-independent prostate cancer.

    SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.
    Park SY, Na Y, Lee MH, Seo JS, Lee YH, Choi KC, Choi HK, Yoon HG., Free PMC Article

    01/13/2018
    TBLR1 has a role in reducing apoptosis in prostate cancer under androgen deprivation

    Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation.
    Daniels G, Zhang X, Zhong X, Santiago L, Wang LH, Wu X, Zhang JY, Liang F, Li X, Neubert TA, Steinke L, Shen Y, Basch R, Schneider R, Levy DE, Lee P., Free PMC Article

    01/13/2018
    The patient with Tyr446Cys mutation presents with a submucous cleft palate and hydronephrosis in addition to severe delays, hypotonia, dysmorphic findings and emerging scoliosis, consistent with previous reports.

    Pierpont syndrome associated with the p.Tyr446Cys missense mutation in TBL1XR1.
    Slavotinek A, Pua H, Hodoglugil U, Abadie J, Shieh J, Van Ziffle J, Kvale M, Lee H, Kwok PY, Risch N, Sabbadini M.

    12/9/2017
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