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    SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 80274, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7.

    SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7.
    Qu X, Huang D, Zhou X, Ruan W., Free PMC Article

    02/20/2024
    Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?

    Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?
    Ayvaz Çelik HH, Kuyumcu MS, Şirin FB, Cirit M, Korkmaz S, Erturan İ, Çelik S, Yıldırım M., Free PMC Article

    11/2/2023
    The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.

    The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.
    Xiao L, Wang M, Yang S, Li S, Huang Q, Xu L, Li Y, Fu Y., Free PMC Article

    04/21/2023
    Predictive Value of Combined Plasma D-Dimer, SCUBE1, and Right Ventricular Tei Index for the Prognosis of Elderly Patients with Acute Pulmonary Thromboembolism.

    Predictive Value of Combined Plasma D-Dimer, SCUBE1, and Right Ventricular Tei Index for the Prognosis of Elderly Patients with Acute Pulmonary Thromboembolism.
    Yang M, Liu Y, Ma Y, Wang W.

    03/4/2023
    SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients.

    SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients.
    Toprak K, Kaplangoray M, Palice A, Taşcanov MB, İnanır M, Memioğlu T, Kök Z, Biçer A, Demirbağ R., Free PMC Article

    12/3/2022
    Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery.

    Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery.
    Özkara T, Yüksel V, Güçlü O, Hüseyin S, Özgün E, Turan FN, Canbaz S.

    01/15/2022
    Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus.

    Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus.
    Bayoglu Tekin Y, Baki Erin K, Yilmaz A.

    02/13/2021
    The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.

    The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.
    Gündüz İ, Batmaz İ, Bozan T, Ekinci A, Cevik R.

    02/2/2021
    De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

    De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
    Cappi C, Oliphant ME, Péter Z, Zai G, Conceição do Rosário M, Sullivan CAW, Gupta AR, Hoffman EJ, Virdee M, Olfson E, Abdallah SB, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV., Free PMC Article

    01/9/2021
    Hemodialysis may contribute to cardiovascular events because of increased SCUBE1 levels after hemodialysis; however, no association was shown between SCUBE1 and electrocardiography/echocardiography findings.

    Relationship Between SCUBE1 Levels and Echocardiography and Electrocardiography Findings and Epicardial Adipose Tissue/Carotid Intima-Media Thickness in Patients Receiving Renal Replacement Therapy.
    Ayan H, Akilli R, Kaya B, Paydas S, Kara E, Cureoglu A.

    06/29/2019
    The results of this pioneering study indicate that SCUBE protein family appears to have a probable role in the pathogenesis and angiogenesis development in psoriasis and SCUBE 1 and 3 may be novel markers of angiogenesis in psoriasis.

    Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis?
    Capkin AA, Demir S, Mentese A, Bulut Ç, Ayar A.

    04/1/2017
    enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aneurysmal subarachnoid hemorrhage patients, indicating SCUBE1 might have the potential to identify aneurysmal subarachnoid hemorrhage patients at risk of poor prognosis

    Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage.
    Ding YS, Sun B, Jiang JX, Zhang Q, Lu J, Gao GZ.

    02/18/2017
    Increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of intracerebral hemorrhage

    The prognostic value of serum signal peptide-Cub-Egf domain-containing protein-1 concentrations in acute intracerebral hemorrhage.
    Qiu SZ, Wang HX, Shen J, Zheng GR, Chen B, Huang JJ, Gao JB.

    02/18/2017
    SCUBE1 might be a novel prognostic biomarker after traumatic brain injury

    Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury.
    Chen QH, Lin D, Zhou J, Deng G.

    12/24/2016
    describe novel mechanisms in targeting S1 to the plasma membrane and demonstrate that N-glycans are required for S1 functions during primitive haematopoiesis in zebrafish.

    Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling.
    Liao WJ, Tsao KC, Yang RB.

    08/20/2016
    SCUBE1 may indicate hypercoagulability in patients with BC and thus help identify patients at greater risk of thrombosisSCUBE1 may indicate hypercoagulability in patients with breast cancer and thus help identify patients at greater risk of thrombosis

    Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer.
    Topcu TO, Kavgaci H, Ozdemir F, Aksoy A, Erdem D, Mentese A, Yaman H, Tufan G, Orem A, Aydin F.

    07/2/2016
    SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF.

    The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever.
    Menteşe A, Yilmaz G, Sümer A, Arslan M, Karahan SC, Köksal I.

    05/10/2014
    Primary prostatic cancer-associated fibroblasts (CAFs) were isolated and the expression of CAF markers, Dlk1 and SCUBE1 transcripts were characterised.

    Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1.
    Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA., Free PMC Article

    09/14/2013
    SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects.

    Is SCUBE 1 a new biomarker for gastric cancer?
    Mentese A, Fidan E, Sumer AU, Karahan SC, Sonmez M, Altay DU, Kavgaci H, Alver A.

    05/11/2013
    SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event.

    Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level.
    Ulusoy S, Ozkan G, Menteşe A, Yavuz A, Karahan SC, Sümer AU.

    04/13/2013
    Observational study of gene-disease association. (HuGE Navigator)

    A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
    Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD.

    12/5/2010
    identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis

    Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.
    Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN.

    01/21/2010
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