| Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation. | Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation.
Qin L, Dong Z, Huang C, Liu H, Beebe J, Subramaniyan B, Hao Y, Liu Y, He Z, Liu JY, Zhang JT. | 07/6/2023 |
| lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by upregulating PDGFD. | lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by upregulating PDGFD.
Yao J, Liu X., Free PMC Article | 06/15/2023 |
| Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-beta reveals anticancer effect in breast cancer. | Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-β reveals anticancer effect in breast cancer.
Şalva E, Özbaş S, Alan S, Özkan N, Ekentok-Atıcı C, Kabasakal L, Akbuğa J. | 02/13/2023 |
| Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression. | Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression.
Parry CM, Chan LF, Carr DF, Hawcutt DB., Free PMC Article | 02/4/2023 |
| ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D. | ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D.
Zheng J, Guo Z, Wen Z, Chen H. | 11/5/2022 |
| E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of beta-PDGFR. | E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.
Pham T, Najy AJ, Kim HC., Free PMC Article | 07/2/2022 |
| PDGF-D-PDGFRbeta signaling enhances IL-15-mediated human natural killer cell survival. | PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival.
Ma S, Tang T, Wu X, Mansour AG, Lu T, Zhang J, Wang LS, Caligiuri MA, Yu J., Free PMC Article | 02/26/2022 |
| Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. | Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK., Free PMC Article | 02/19/2022 |
| Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-kappaB activation. | Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-κB activation.
Wang H, Nian L, Li Z, Lu C. | 12/11/2021 |
| A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma. | A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma.
Sun Y, Sedgwick AJ, Palarasah Y, Mangiola S, Barrow AD., Free PMC Article | 10/23/2021 |
| Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma. | Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.
Gao X, Yang J, Chen Y. | 04/3/2021 |
| PDGFD induces ibrutinib resistance of diffuse large Bcell lymphoma through activation of EGFR. | PDGFD induces ibrutinib resistance of diffuse large B‑cell lymphoma through activation of EGFR.
Jin J, Wang L, Tao Z, Zhang J, Lv F, Cao J, Hu X., Free PMC Article | 02/13/2021 |
| We report the first recurrent molecular variant of dermatofibrosarcoma protuberans involving PDGFD | Alternative PDGFD rearrangements in dermatofibrosarcomas protuberans without PDGFB fusions.
Dadone-Montaudié B, Alberti L, Duc A, Delespaul L, Lesluyes T, Pérot G, Lançon A, Paindavoine S, Di Mauro I, Blay JY, de la Fouchardière A, Chibon F, Karanian M, MacGrogan G, Kubiniek V, Keslair F, Cardot-Leccia N, Michot A, Perrin V, Zekri Y, Coindre JM, Tirode F, Pedeutour F, Ranchère-Vince D, Le Loarer F, Pissaloux D. | 08/24/2019 |
| PDGF-C and PDGF-D are relatively new members of the PDGF family and are potent angiogenic and survival factors. Recent studies have demonstrated their important roles in different types of eye diseases. [review] | PDGF-C and PDGF-D in ocular diseases.
Kumar A, Li X. | 06/15/2019 |
| Numerous studies have shown that PDGF-C and PDGF-D are critical regulators of the cardiovascular system as angiogenic and survival factors. PDGF-C and PDGFD are widely expressed in many different types of cells with pleotropic effects. [review] | Platelet-derived growth factor-C and -D in the cardiovascular system and diseases.
Lee C, Li X. | 06/15/2019 |
| PDGF-D and its PDGF receptor beta (PDGFR-beta) are expressed in colorectal cancer. | Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer.
Olsen RS, Dimberg J, Geffers R, Wågsäter D. | 03/30/2019 |
| PDGF-D overexpression is an independent predictor of platinum-based chemotherapy resistance and it may also be a potential biomarker for targeted therapy and poor prognosis. | Platelet-Derived Growth Factor D Is a Prognostic Biomarker and Is Associated With Platinum Resistance in Epithelial Ovarian Cancer.
Zhang M, Liu T, Xia B, Yang C, Hou S, Xie W, Lou G. | 01/12/2019 |
| PDGF-D promotes tumor growth and aggressiveness of colorectal carcinoma. Down-regulation of PDGF-D inactivates Notch1/Twist1 axis, which could reverse epithelial mesenchymal transformation and prevent CRC progression. | PDGF-D promotes cell growth, aggressiveness, angiogenesis and EMT transformation of colorectal cancer by activation of Notch1/Twist1 pathway.
Chen J, Yuan W, Wu L, Tang Q, Xia Q, Ji J, Liu Z, Ma Z, Zhou Z, Cheng Y, Shu X., Free PMC Article | 02/24/2018 |
| significant correlations between DNA methylation of the PDGFD gene promoter and the risk of developing either IA or BAVM | DNA Methylation of the PDGFD Gene Promoter Increases the Risk for Intracranial Aneurysms and Brain Arteriovenous Malformations.
Zhou S, Gao X, Sun J, Lin Z, Huang Y. | 09/9/2017 |
| This study suggested that epithelial-mesenchymal transition process can be triggered by the PDGF-D/PDGFRb axis in tongue squamous cell carcinoma, and then involved in the tumor cell invasion via activation of p38/AKT/ERK/ epithelial-mesenchymal transition pathway. | PDGF-D/PDGFRβ promotes tongue squamous carcinoma cell (TSCC) progression via activating p38/AKT/ERK/EMT signal pathway.
Zhang H, Sun JD, Yan LJ, Zhao XP. | 05/20/2017 |
| No specific genotype of rs974819 of Platelet-derived growth factor D demonstrated increased cardiovascular mortality in the total population, however, the male group with genotypes A/A and G/A demonstrated an increased risk that persisted in a multivariate evaluation where adjustments were made for well-known cardiovascular risk factors. | PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men.
Alehagen U, Olsen RS, Länne T, Matussek A, Wågsäter D., Free PMC Article | 05/6/2017 |
| There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. | PDGFs and their receptors.
Kazlauskas A., Free PMC Article | 04/22/2017 |
| upregulated in kidney fibrosis, may mediate renal scarring, and is dispensable for normal kidney development and physiological functions | The role of PDGF-D in healthy and fibrotic kidneys.
Buhl EM, Djudjaj S, Babickova J, Klinkhammer BM, Folestad E, Borkham-Kamphorst E, Weiskirchen R, Hudkins K, Alpers CE, Eriksson U, Floege J, Boor P. | 02/4/2017 |
| polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population | A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
Han J, Li H, Wu D, Zeng N, Wu Z, Cai L, Chen W, Zuo W, Zhang Y. | 10/22/2016 |
| Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis. | Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.
Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR., Free PMC Article | 07/2/2016 |