| SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression. | SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression.
Ma YN, Zou YD, Liu ZL, Wu GX, Zhou YZ, Luo CX, Huang XT, Xie ML, Xu SN, Li X. | 02/27/2024 |
| Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia. | Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia.
Liu Y, Sun J, Zhang C, Wu Y, Ma S, Li X, Wu X, Gao Q., Free PMC Article | 02/6/2024 |
| Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss. | Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.
Cesarato N, Schwieger-Briel A, Gossmann Y, Henne SK, Hillmann K, Frommherz LH, Wehner M, Xiong X, Thiele H, Oji V, Milani D, Tantcheva-Poor I, Giehl K, Fölster-Holst R, Teichler A, Braeckmans D, Hoeger PH, Jones G, Frank J, Weibel L, Blume-Peytavi U, Hamm H, Nöthen MM, Geyer M, Heilmann-Heimbach S, Basmanav FB, Betz RC. | 11/22/2023 |
| The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients. | The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.
Ramirez I, Kirschneck C, Corrêa Silva-Sousa A, Proff P, S Antunes L, Gabbardo MCL, Silva Barroso de Oliveira D, Sousa-Neto MD, Baratto-Filho F, Küchler EC., Free PMC Article | 08/14/2023 |
| Phenotypic characteristics of taurodontism and a novel WNT10A variant in non-syndromic oligodontia family. | Phenotypic characteristics of taurodontism and a novel WNT10A variant in non-syndromic oligodontia family.
Zhao Y, Hou Y, Ren J, Gao X, Meng L, Liu Y, Xing C, Shen W. | 08/14/2023 |
| Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites. | Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites.
Kantaputra P, Jatooratthawichot P, Tantachamroon O, Nanekrungsan K, Intachai W, Olsen B, Tongsima S, Ngamphiw C, Cairns JRK., Free PMC Article | 01/28/2023 |
| WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer. | WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer.
Bielik P, Bonczek O, Krejčí P, Zeman T, Izakovičová-Hollá L, Šoukalová J, Vaněk J, Vojtěšek B, Lochman J, Balcar VJ, Šerý O. | 12/10/2022 |
| Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer. | Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer.
Foster JW, Parikh RN, Wang J, Bower KS, Matthaei M, Chakravarti S, Jun AS, Eberhart CG, Soiberman US., Free PMC Article | 10/2/2021 |
| WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints. | WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints.
Cao X, Wang X, Zhang W, Xia G, Zhang L, Wen Z, He J, Wang Z, Huang J, Wu S. | 07/10/2021 |
| Functional Effects of WNT10A Rare Variants Associated with Tooth Agenesis. | Functional Effects of WNT10A Rare Variants Associated with Tooth Agenesis.
Zeng Y, Baugh E, Akyalcin S, Letra A. | 05/1/2021 |
| The WNT10A gene has been confirmed as the second molecular candidate that has been identified and accounts for one-half of non-EDA patients and one-third of NSTA patients. | EDA, EDAR, EDARADD and WNT10A allelic variants in patients with ectodermal derivative impairment in the Spanish population.
Martínez-Romero MC, Ballesta-Martínez MJ, López-González V, Sánchez-Soler MJ, Serrano-Antón AT, Barreda-Sánchez M, Rodriguez-Peña L, Martínez-Menchon MT, Frías-Iniesta J, Sánchez-Pedreño P, Carbonell-Meseguer P, Glover-López G, Guillén-Navarro E, GIEDE (Spanish multidisciplinary research group for ectodermal dysplasia)., Free PMC Article | 08/1/2020 |
| The WNT10A variant p.Arg104His was expected to abolish the essential hydrogen bonds with the Cys and Gly residues of the thumb domain which eventually led to a significant deviation from the starting structure and gradual flexibility of C-terminal thumb domain over the period of 100ns. | Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations.
Parveen A, Khan SA, Mirza MU, Bashir H, Arshad F, Iqbal M, Ahmad W, Wahab A, Fiaz A, Naz S, Ashraf F, Mobeen T, Aziz S, Ahmed SS, Muhammad N, Hassib NF, Mostafa MI, Gaboon NE, Gul R, Khan S, Froeyen M, Shoaib M, Wasif N., Free PMC Article | 03/7/2020 |
| we found that bi-allelic mutations in the WNT10A gene preferentially affect the permanent dentition rather the primary dentition, suggesting that the molecular mechanisms regulated by WNT10A in the development of permanent teeth and deciduous teeth might be different. | Distinct impacts of bi-allelic WNT10A mutations on the permanent and primary dentitions in odonto-onycho-dermal dysplasia.
Yu M, Liu Y, Liu H, Wong SW, He H, Zhang X, Wang Y, Han D, Feng H. | 02/15/2020 |
| Multiple phenotypes are found in individuals presenting mutations in the WNT10A gene. Among them, the stop codon p.C107* as well as the biallelic p.F228I variants correlate with the most severe oligodontia phenotypes | Prevalence of WNT10A gene mutations in non-syndromic oligodontia.
Ruiz-Heiland G, Lenz S, Bock N, Ruf S. | 01/11/2020 |
| we found an rs147680216 G>A mutation that was associated with non-syndromic cleft lip and palate in the Wnt10a gene | WNT10A rs147680216 G>A mutation indicates a higher risk for non-syndromic oral cleft in a northeastern Chinese population.
Feng C, Wang Q, Cao Z, Guan H, Xu ZF. | 12/14/2019 |
| We performed molecular genetic testing for pathogenetic mutations in the WNT10A gene, which showed a heterozygous missense mutation in exon 2 and exon 4 both leading to amino acid substitution. | Schöpf-Schulz-Passarge syndrome associated with two new missense mutations in WNT10A.
Pauly KJ, Balakirski G, Megahed M, Rübben A, Schmitt L. | 10/5/2019 |
| In 7 families afflicted with dental anomalies we detected 4 heterozygous missense variants in WNT10B. We performed whole exome sequencing in the patients who had WNT10B mutations and found no mutations in other known hypodontia-associated genes..They also show that WNT10B variants are associated not only with oligodontia and isolated tooth agenesis, but also with microdontia, short tooth roots, dental pulp stones | WNT10B mutations associated with isolated dental anomalies.
Kantaputra PN, Hutsadaloi A, Kaewgahya M, Intachai W, German R, Koparal M, Leethanakul C, Tolun A, Ketudat Cairns JR. | 09/28/2019 |
| The study confirmed that Phe228Ile is the most frequent WNT10A variant in Caucasian populations, and that WNT10A mutations are associated with large variability in EDI. | WNT10A gene is the second molecular candidate in a cohort of young Italian subjects with ectodermal derivative impairment (EDI).
Guazzarotti L, Tadini G, Mancini GE, Sani I, Pisanelli S, Galderisi F, D'Auria E, Secondi R, Bottero A, Zuccotti GV. | 09/14/2019 |
| Novel Wnt10A mutations (c.521T>C and c.653T>G) and EVC2 mutation (c.1472C>T) were identified in families with selective tooth agenesis. The Wnt10A c.521T>C mutation and the EVC2 c.1472C>T mutation were considered as pathogenic for affecting highly conserved amino acids, co-segregated with phenotype and predicted to be disease-causing by SIFT and PolyPhen2. | Novel mutations identified in patients with tooth agenesis by whole-exome sequencing.
Zhao K, Lian M, Zou D, Huang W, Zhou W, Shen Y, Wang F, Wu Y. | 07/6/2019 |
| Significant associations were found between individual SNPs and SNP combinations in WNT10A, WNT10B and GREM2 SNPs with isolated tooth agenesis | Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis.
Magruder S, Carter E, Williams MA, English J, Akyalcin S, Letra A. | 06/1/2019 |
| WNT10A mutations in Schopf-Schulz-Passarge syndrome patients suggest phenotypic expression is not a result of the mutation alone, but is influenced by other currently unknown factors. | Schöpf-Schulz-Passarge Syndrome: Previously Unreported WNT10A Genotype and Phenotypes in 9 Family Members.
Zimmermann CE, Soufi M, Ruppert V, Schaefer JR, von Domarus H. | 06/1/2019 |
| The distributions of WNT10A gene rs10177996 SNP among Han nationality in Urumqi area, Uygur nationality in Kashgar area and the reported European population are obviously different. | [Distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area].
Liu JL, Zhao CP, Zhang JY, Han XZ, Ge SP, DU LJ, He HY. | 02/23/2019 |
| Polymorphisms in WNT10A is associated with maxillary lateral incisor agenesis. | WNT10A variants in relation to nonsyndromic hypodontia in eastern Slovak population.
Grejtakova D, Gabrikova-Dojcakova D, Boronova I, Kyjovska L, Hubcejova J, Fecenkova M, Zigova M, Priganc M, Bernasovska J. | 02/16/2019 |
| No up-regulation of Wnt10A and IGF-1 mRNA was observed with 1,550-nm Er:Glass fractional laser treatment of androgenetic alopecia. | Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.
Meephansan J, Ungpraphakorn N, Ponnikorn S, Suchonwanit P, Poovorawan Y. | 12/22/2018 |
| Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4. | WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE., Free PMC Article | 11/24/2018 |