| MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1. | MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1.
Shi Y, Yi Z, Zhao P, Xu Y, Pan P., Free PMC Article | 07/31/2021 |
| Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1. | Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1.
Li J, Luo M, Wang S, Jin G, Han Z, Ma Y, Tang G, Guo Z., Free PMC Article | 04/24/2021 |
| CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity. | CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity.
Docsa T, Bhattarai D, Sipos A, Wade CE, Cox CS Jr, Uray K. | 02/13/2021 |
| Swimming Physical Training Prevented the Onset of Acute Muscle Pain by a Mechanism Dependent of PPARgamma Receptors and CINC-1. | Swimming Physical Training Prevented the Onset of Acute Muscle Pain by a Mechanism Dependent of PPARγ Receptors and CINC-1.
de Azambuja G, Botasso Gomes B, Messias LHD, Aquino BM, Jorge CO, Manchado-Gobatto FB, Oliveira-Fusaro MCG. | 02/6/2021 |
| Participation of CXCL1 in the glial cells during neuropathic pain. | Participation of CXCL1 in the glial cells during neuropathic pain.
Moraes TR, Elisei LS, Malta IH, Galdino G. | 01/9/2021 |
| An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma. | An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma.
Dahlquist KJV, Voth LC, Fee AJ, Stoeckman AK. | 11/21/2020 |
| Propionibacterium acnes stimulate the nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 via TLR2/NF-kappaBp65 pathway. | Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2-NF-κB p65 pathway.
Jiao Y, Yuan Y, Lin Y, Zhou Z, Zheng Y, Wu W, Tang G, Chen Y, Xiao J, Li C, Chen Z, Cao P. | 05/9/2020 |
| CINC-1 might contribute to LPS-induced fever in rats by activating CXCR2 receptor on the CNS. | Role of CINC-1 and CXCR2 receptors on LPS-induced fever in rats.
Yamashiro LH, de Souza GEP, de Melo Soares D. | 03/21/2020 |
| CXCL1 inhibits axon outgrowth of dorsal root ganglia neurons. | CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons.
Deftu AT, Ciorescu R, Gheorghe RO, Mihăilescu D, Ristoiu V. | 01/25/2020 |
| These data are concomitant with abnormal cerebral CXCL1/CXCR2 expression, and support temporal aberrations in CXCL1/CXCR2 and neutrophil dynamics in the placental-fetal-brain axis following chorioamnionitis | Preclinical chorioamnionitis dysregulates CXCL1/CXCR2 signaling throughout the placental-fetal-brain axis.
Yellowhair TR, Noor S, Maxwell JR, Anstine CV, Oppong AY, Robinson S, Milligan ED, Jantzie LL. | 11/10/2018 |
| The results showed that after short-term incubation both CXCL1 and CXCL2 can activate TRPV1+/IB4+ DRG neurons by significantly reducing TRPV1 desensitization, while at acute application both chemokines induced an increase in [Ca2+]i although of different amplitudes, in a subset of neurons partially also itch-sensitive in the case of CXCL1, or non-itch sensitive in the case of CXCL2. | Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application.
Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu V. | 05/12/2018 |
| Findings indicated that up-regulation of CXCL1 and CXCR2 might contribute to remifentanil-induce hypernociception via modulating spinal NR2B-containing NMDA receptor expression and phosphorylation in rats. | Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats.
Yang LH, Xu GM, Wang Y. | 06/24/2017 |
| remote ischemic preconditioning protects hepatic microcirculation by induction of HO and modulation of cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury | Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury.
Tapuria N, Junnarkar S, Abu-Amara M, Fuller B, Seifalian AM, Davidson BR., Free PMC Article | 05/20/2017 |
| Results results demonstrate that sphingosine-1-phosphate induces Ca(2+) signaling in astrocytes via Gq -coupled receptors S1P2 and S1P3 , followed by Ca(2+) influx through TRPC6 that could activate MAPK signaling, which leads to increased secretion of the proinflammatory or neuroprotective chemokine CXCL1 | Sphingosine-1-phosphate induces Ca(2+) signaling and CXCL1 release via TRPC6 channel in astrocytes.
Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, Nagayasu K, Nakagawa T, Kaneko S. | 05/6/2017 |
| aging can reduce the expression of CINC and MCP-1 mRNA in lung tissues, and reduce the infiltration of neutrophils and monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk of pneumonia in elderly patients. | Aging reduces the expression of lung CINC and MCP-1 mRNA in a P. aeruginosa rat model of infection.
Wen J, Li CM, Gu L, Yin SJ, Li W, Yang R., Free PMC Article | 06/20/2015 |
| In opioid-tolerant rats, CXCL1 is up-regulated in CSF; as it is in patients also. | Role of spinal CXCL1 (GROα) in opioid tolerance: a human-to-rodent translational study.
Lin CP, Kang KH, Lin TH, Wu MY, Liou HC, Chuang WJ, Sun WZ, Fu WM. | 04/18/2015 |
| IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II. | NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription.
Burke SJ, Lu D, Sparer TE, Masi T, Goff MR, Karlstad MD, Collier JJ., Free PMC Article | 03/15/2014 |
| Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC. | Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC.
Dong F, Du YR, Xie W, Strong JA, He XJ, Zhang JM., Free PMC Article | 12/8/2012 |
| CXCL1 inhibition of oligodendrocyte progenitor cell migration is regulated via changes in intracellular calcium flux. | CXCL1 regulation of oligodendrocyte progenitor cell migration is independent of calcium signaling.
Vora P, Pillai P, Mustapha J, Kowal C, Shaffer S, Bose R, Namaka M, Frost EE. | 09/22/2012 |
| hyperoxia exposure led to a suppression of the HDAC1/HDAC2 expression and activity, and the overall HDAC activity, as well as arrest of alveolarization, and an elevated expression of CINC-1 in the lungs of newborn rats | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats.
Zhu L, Li H, Tang J, Zhu J, Zhang Y. | 06/16/2012 |
| Advanced glycation end products promote the secretion of MCP-1 and IL-8 in vascular smooth muscle cells. | [Effects of advanced glycation end products on the secretion of proinflammatory chemokines in vascular smooth muscle cells].
He R, Mao JM, Wang G, Gao W. | 12/16/2011 |
| Severe burn injury activates pulmonary NF-kappaB and leads to secretion of IL8 and TNF alpha in the lung. | [Effect of nuclear factor-kappaB activation on expression of proinflammatory cytokines in rat lung tissues in early stage of burn injury].
Li ZQ, Huang YS, Yang ZC, Wang JH. | 12/16/2011 |
| In rats with chronic nonbacterial prostatitis, the levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the curcumin-treated group than in the positive control group. | [Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis].
Zhang QY, Mo ZN, Liu XD. | 12/16/2011 |
| ATP-stimulated C6 glioma cells showed enhanced expression of MCP-1 & IL-8; elevated levels of MCP-1 & IL-8 are predicted to enhance mobility of tumor cells & promote recruitment of microglia into developing tumors thereby supporting tumor growth. | ATP stimulates chemokine production via a store-operated calcium entry pathway in C6 glioma cells.
Jantaratnotai N, Choi HB, McLarnon JG., Free PMC Article | 12/16/2011 |
| Data show significant concentration increases for CXCL1 and MIP-1alpha in the brain after soman-induced seizure onset. | Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats.
Johnson EA, Dao TL, Guignet MA, Geddes CE, Koemeter-Cox AI, Kan RK., Free PMC Article | 10/8/2011 |