| Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations. | Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.
Tsai MH, Ke HC, Lin WC, Nian FS, Huang CW, Cheng HY, Hsu CS, Granata T, Chang CH, Castellotti B, Lin SY, Doniselli FM, Lu CJ, Franceschetti S, Ragona F, Hou PS, Canafoglia L, Tung CY, Lee MH, Wang WJ, Tsai JW., Free PMC Article | 01/16/2024 |
| Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study. | Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study.
Habibi S, Yaghoubzad-Maleki M, Heshmati E, Khalifeh K. | 11/27/2023 |
| Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways. | Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways.
Garrott SR, Gillies JP, Siva A, Little SR, El Jbeily R, DeSantis ME., Free PMC Article | 07/6/2023 |
| DYRK2 phosphorylates NDEL1 S336 to prime the phosphorylation of NDEL1 S332 by GSK3beta. The data suggest the NDEL1 phosphorylation at S336/S332 by the TARA-DYRK2-GSK3beta complex as a novel regulatory mechanism underlying neuronal morphogenesis. | Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Woo Y, Kim SJ, Suh BK, Kwak Y, Jung HJ, Nhung TTM, Mun DJ, Hong JH, Noh SJ, Kim S, Lee A, Baek ST, Nguyen MD, Choe Y, Park SK., Free PMC Article | 05/30/2020 |
| observed a positive correlation between Ndel1 activity and the total YMRS score in BD group (p = 0.030) and a positive correlation between ACE activity and Ham-D score | Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme.
Dal Mas C, Carvalho MS, Marins LA, Yonamine CM, Cordeiro Q, McIntyre RS, Mansur RB, Brietzke E, Hayashi MAF. | 03/30/2019 |
| Results demonstrate that Ndel1 interacts with Tara to regulate cell movement revealing a novel role of the Ndel1-Tara complex in actin reorganization during cell movement. | Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration.
Hong JH, Kwak Y, Woo Y, Park C, Lee SA, Lee H, Park SJ, Suh Y, Suh BK, Goo BS, Mun DJ, Sanada K, Nguyen MD, Park SK., Free PMC Article | 05/19/2018 |
| results highlight S-Nitrosylation as a key activity-dependent mechanism underlying neonatal brain maturation and suggest that reduction of S-Nitrosylation of NDEL1 acts as a pathological factor mediating neurodevelopmental abnormalities caused by maternal alcohol exposure | Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A., Free PMC Article | 05/5/2018 |
| disrupting DISC1/Ndel1 complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids | DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.
Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, Mao M, Poon RYC, Kim J, Song H, Ming GL, Zhang M., Free PMC Article | 12/23/2017 |
| Study showed that Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia physiopathology | Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity.
Gadelha A, Coleman J, Breen G, Mazzoti DR, Yonamine CM, Pellegrino R, Ota VK, Belangero SI, Glessner J, Sleiman P, Hakonarson H, Hayashi MA, Bressan RA. | 12/31/2016 |
| This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls. | Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis.
Ota VK, Noto C, Santoro ML, Spindola LM, Gouvea ES, Carvalho CM, Santos CM, Xavier G, Higuchi CH, Yonamine C, Moretti PN, Abílio VC, Hayashi MA, Brietzke E, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI. | 10/8/2016 |
| study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder | The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.
Pei Z, Lang B, Fragoso YD, Shearer KD, Zhao L, Mccaffery PJ, Shen S, Ding YQ, McCaig CD, Collinson JM., Free PMC Article | 01/17/2015 |
| The Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia. | Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia--a potential biomarker?
Gadelha A, Machado MF, Yonamine CM, Sato JR, Juliano MA, Oliveira V, Bressan RA, Hayashi MA. | 09/14/2013 |
| Short (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and phosphodiesterase (PDE)4B proteins, but fully interact with FEZ1 and glycogen synthase kinase 3 (GSK3)beta. | Interactions of human truncated DISC1 proteins: implications for schizophrenia.
Newburn EN, Hyde TM, Ye T, Morita Y, Weinberger DR, Kleinman JE, Lipska BK., Free PMC Article | 04/6/2013 |
| Nudel markedly promotes the HSPC300-WAVE2 interaction. | Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions.
Wu S, Ma L, Wu Y, Zeng R, Zhu X., Free PMC Article | 12/22/2012 |
| analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly. | The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
Soares DC, Bradshaw NJ, Zou J, Kennaway CK, Hamilton RS, Chen ZA, Wear MA, Blackburn EA, Bramham J, Böttcher B, Millar JK, Barlow PN, Walkinshaw MD, Rappsilber J, Porteous DJ., Free PMC Article | 12/8/2012 |
| Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation. | Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance.
Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., Free PMC Article | 10/27/2012 |
| Studies indicate that binding of dynactin, LIS1 and NudEL regulate cytoplasmic dynein motor activity. | Multiple modes of cytoplasmic dynein regulation.
Vallee RB, McKenney RJ, Ori-McKenney KM. | 05/12/2012 |
| DISC1 forms octamers via dimers as building blocks. S704C forms higher-order oligomers, without affecting its affinity with NDEL1 | Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.
Narayanan S, Arthanari H, Wolfe MS, Wagner G., Free PMC Article | 02/25/2012 |
| Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport. | Ndel1, Nudel (Noodle): flexible in the cell?
Chansard M, Hong JH, Park YU, Park SK, Nguyen MD. | 02/4/2012 |
| Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. | Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
Nicodemus KK, Callicott JH, Higier RG, Luna A, Nixon DC, Lipska BK, Vakkalanka R, Giegling I, Rujescu D, St Clair D, Muglia P, Shugart YY, Weinberger DR. | 05/7/2011 |
| The truncated monomeric form of LIS1 had little effect on dynein motility, but an artificial dimer of truncated LIS1 suppressed dynein motility, which was restored by the N-terminal fragment of NDEL1. | Functional dissection of LIS1 and NDEL1 towards understanding the molecular mechanisms of cytoplasmic dynein regulation.
Torisawa T, Nakayama A, Furuta K, Yamada M, Hirotsune S, Toyoshima YY., Free PMC Article | 02/26/2011 |
| NDEL1 is essential for a specific late step of neuronal migration: entry into the target lamina. | Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration.
Hippenmeyer S, Youn YH, Moon HM, Miyamichi K, Zong H, Wynshaw-Boris A, Luo L., Free PMC Article | 01/8/2011 |
| This data supports a physiological role for the endooligopeptidase activity of Ndel1 and suggests it plays a key role during neurite outgrowth. | Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth.
Hayashi MA, Guerreiro JR, Charych E, Kamiya A, Barbosa RL, Machado MF, Campeiro JD, Oliveira V, Sawa A, Camargo AC, Brandon NJ. | 11/13/2010 |
| Findings suggest that physiological functions of LIS1 and NDEL1 in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control. | The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis.
Yamada M, Hirotsune S, Wynshaw-Boris A., Free PMC Article | 11/6/2010 |
| NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane. | Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.
Lam C, Vergnolle MA, Thorpe L, Woodman PG, Allan VJ. | 03/8/2010 |