| Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis. | Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis.
Kocatürk B., Free PMC Article | 02/24/2023 |
| The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications. | The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications.
Hung CT, Tsai YW, Wu YS, Yeh CF, Yang KC., Free PMC Article | 09/10/2022 |
| The role and mechanism of TXNDC5 in diseases. | The role and mechanism of TXNDC5 in diseases.
Wang X, Li H, Chang X., Free PMC Article | 08/13/2022 |
| Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p. | Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p.
Lu H, Gao L, Lv J. | 03/19/2022 |
| Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. | Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC., Free PMC Article | 09/19/2020 |
| serum levels were elevated in both early-onset and late-onset pre-eclampsia | Maternal serum TXNDC5 levels and thiol/disulfide homeostasis in preeclamptic pregnancies.
Kaya B, Turhan U, Sezer S, Bestel A, Okumuş ZG, Dağ İ, Erel Ö. | 06/6/2020 |
| HERG1 contributes to poor prognosis in patients with esophageal squamous cell carcinoma (ESCC) by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K/AKT signaling pathway. Our findings provided novel insights into the pathology of ESCC and role of HERG1 in tumor progression, suggesting that targeting HERG1 has potential diagnostic and therapeutic value for ESCC treatment. | HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway.
Wang H, Yang X, Guo Y, Shui L, Li S, Bai Y, Liu Y, Zeng M, Xia J., Free PMC Article | 01/18/2020 |
| These results strongly suggest that high levels of TXNDC5 in Rheumatoid Arthritis synovial tissues suppress CXCL10 and TNFSF10 expression. | CXCL10 and TRAIL Are Upregulated by TXNDC5 in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Xu B, Li J, Wu C, Liu C, Yan X, Chang X. | 10/26/2019 |
| Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in rheumatoid arthritis synovial fibroblasts, highlighting a potential approach to treat rheumatoid arthritis by blocking the TXNDC5/HSC70 interaction. | TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-κB signaling.
Wang L, Dong H, Song G, Zhang R, Pan J, Han J., Free PMC Article | 10/5/2019 |
| TXNDC5 mRNA and protein were highly upregulated in failing human left ventricles. TXNDC5 mRNA and protein were increased in human cardiac fibroblasts under transforming growth factor beta1 stimulation in vitro.TXNDC5 knockdown attenuated TGFbeta1-induced activation and ECM protein upregulation independent of SMAD3, but increasing expression of TXNDC5 triggered activation and proliferation and increased ECM protein prod... | Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC., Free PMC Article | 09/14/2019 |
| TXNDC5 contributes to abnormal rheumatoid arthritis synovial fibroblast-like cells proliferation, migration and IL-6 production by inhibiting IGFBP1 expression. | TXNDC5 contributes to rheumatoid arthritis by down-regulating IGFBP1 expression.
Li J, Xu B, Wu C, Yan X, Zhang L, Chang X., Free PMC Article | 03/30/2019 |
| the mannose-trimming activity of EDEM3 toward the model misfolded substrate, the glycoprotein T-cell receptor alpha locus (TCRalpha), was reconstituted only when ERp46 had established a covalent interaction with EDEM3 | ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3).
Yu S, Ito S, Wada I, Hosokawa N., Free PMC Article | 02/9/2019 |
| Hypoxia induces the expression of TXNDC5 via upregulating HIF-1alpha in colorectal cancer cells. | Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence.
Tan F, Zhu H, He X, Yu N, Zhang X, Xu H, Pei H., Free PMC Article | 10/13/2018 |
| TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo. [review] | [Progress of research on TXNDC5].
Li J, Chang X. | 09/16/2017 |
| High TXNDC5 expression is associated with renal cell carcinoma. | High TXNDC5 expression predicts poor prognosis in renal cell carcinoma.
Mo R, Peng J, Xiao J, Ma J, Li W, Wang J, Ruan Y, Ma S, Hong Y, Wang C, Gao K, Fan J. | 03/4/2017 |
| we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with Castration-resistant prostate cancer. | The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.
Wang L, Song G, Chang X, Tan W, Pan J, Zhu X, Liu Z, Qi M, Yu J, Han B. | 11/28/2015 |
| Role of ERp46 in oxidative protein folding.Independent actions of ERp46 thioredoxin domains on folding substrates.Structure of thioredoxin ERp46 domains. | Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family.
Kojima R, Okumura M, Masui S, Kanemura S, Inoue M, Saiki M, Yamaguchi H, Hikima T, Suzuki M, Akiyama S, Inaba K. | 05/30/2015 |
| suggest that the tumorigenic properties of ERp46 in RCC cells are not related to an inhibitory modulation of AdipoR1 | Endoplasmic reticulum protein ERp46 in renal cell carcinoma.
Duivenvoorden WC, Paschos A, Hopmans SN, Austin RC, Pinthus JH., Free PMC Article | 01/17/2015 |
| Endo-PDI is a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function. | Endo-PDI is required for TNFα-induced angiogenesis.
Camargo LL, Babelova A, Mieth A, Weigert A, Mooz J, Rajalingam K, Heide H, Wittig I, Lopes LR, Brandes RP. | 09/6/2014 |
| TXNDC5 has increased expression in many tumors that is involved in the proliferation and migration of tumor cells, acting as a tumor-enhancing gene. | Investigating a pathogenic role for TXNDC5 in tumors.
Chang X, Xu B, Wang L, Wang Y, Wang Y, Yan S. | 07/19/2014 |
| results suggest that TXNDC5 polymorphisms could be related to the development of HCC in the Korean male population | TXNDC5 gene polymorphism contributes to increased risk of hepatocellular carcinoma in the Korean male population.
Park MS, Kim SK, Shin HP, Lee SM, Chung JH. | 11/30/2013 |
| Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. | Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46.
Pace PE, Peskin AV, Han MH, Hampton MB, Winterbourn CC. | 09/28/2013 |
| Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. | Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
Wang L, Zheng Y, Xu H, Yan X, Chang X., Free PMC Article | 07/6/2013 |
| Authors show that ERp46 is able to bind to a large pool of peptides containing aromatic and basic residues via all three of its catalytic domains (a(0), a and a'), though the a(0) domain may contain the primary binding site. | Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.
Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM. | 05/25/2013 |
| crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution | Structure of the third catalytic domain of the protein disulfide isomerase ERp46.
Gulerez IE, Kozlov G, Rosenauer A, Gehring K., Free PMC Article | 06/30/2012 |