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    CAMK2B calcium/calmodulin dependent protein kinase II beta [ Homo sapiens (human) ]

    Gene ID: 816, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.

    Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
    Borghi R, Trivisano M, Specchio N, Tartaglia M, Compagnucci C.

    08/10/2023
    Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.

    Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
    Bhattacharyya M, Lee YK, Muratcioglu S, Qiu B, Nyayapati P, Schulman H, Groves JT, Kuriyan J., Free PMC Article

    04/3/2021
    CaMKIIbeta in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.

    CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
    Nicole O, Pacary E., Free PMC Article

    03/6/2021
    CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF.

    Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.
    Shugg T, Johnson DE, Shao M, Lai X, Witzmann F, Cummins TR, Rubart-Von-der Lohe M, Hudmon A, Overholser BR., Free PMC Article

    01/19/2019
    The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.

    De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
    Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Undiagnosed Diseases Network, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B, GEM HUGO, Deciphering Developmental Disorders Study, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S., Free PMC Article

    11/18/2017
    TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1.

    Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.
    Mukherjee S, Sheng W, Sun R, Janssen LJ.

    06/24/2017
    Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.

    Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.
    Hung TC, Lee WY, Chen KB, Huang HJ, Chan YC, Lee CC, Chen CY., Free PMC Article

    03/21/2015
    beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells

    β-carotene reverses the IL-1β-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.
    Yamagata K, Tanaka N, Matsufuji H, Chino M.

    04/27/2013
    Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.

    Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
    Jiao Y, Jalan-Sakrikar N, Robison AJ, Baucum AJ 2nd, Bass MA, Colbran RJ., Free PMC Article

    01/28/2012
    Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.

    Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
    Kim JH, Kim TW, Kim SJ.

    12/31/2011
    Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible.

    A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
    Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J., Free PMC Article

    11/5/2011
    The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.

    Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.
    Chai Y, Zhang DM, Lin YF., Free PMC Article

    07/30/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article

    02/11/2009
    Observational study of gene-disease association. (HuGE Navigator)

    A common variant in DRD3 receptor is associated with autism spectrum disorder.
    de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM.

    01/11/2009
    These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo.

    Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity.
    Kwok S, Lee C, Sánchez SA, Hazlett TL, Gratton E, Hayashi Y., Free PMC Article

    01/21/2010
    CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells

    Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
    Yang BF, Xiao C, Roa WH, Krammer PH, Hao C.

    01/21/2010
    exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans

    Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle.
    Rose AJ, Hargreaves M., Free PMC Article

    01/21/2010
    measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms

    Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.
    Gaertner TR, Kolodziej SJ, Wang D, Kobayashi R, Koomen JM, Stoops JK, Waxham MN.

    01/21/2010
    thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II

    Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.
    David-Dufilho M, Millanvoye-Van Brussel E, Topal G, Walch L, Brunet A, Rendu F.

    01/21/2010
    regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII.

    Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.
    Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M.

    01/21/2010
    role in cell communication

    [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions].
    Yamamoto H.

    01/21/2010
    the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events

    Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming.
    Cuschieri J, Bulger E, Garcia I, Jelacic S, Maier RV.

    01/21/2010
    Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees

    Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calciuum/calmodulin-dependent protein kinase II.
    Li G, Laabich A, Liu LO, Xue J, Cooper NG.

    01/21/2010
    expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases

    Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression.
    Novak G, Seeman P, Tallerico T.

    01/21/2010
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