| AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte. | AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
Fang Y, Xu J, Huang R. | 02/21/2024 |
| Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection. | Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection.
Bastola T, Perkins GA, Kim KY, Choi S, Kwon JW, Shen Z, Strack S, Ju WK., Free PMC Article | 06/14/2023 |
| AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing. | AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.
Xiang H, Xu H, Tan B, Yi Q, Zhang X, Wang R, Chen T, Xie Q, Tian J, Zhu J., Free PMC Article | 06/7/2023 |
| Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. | Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.
Vergnes L, Lin JY, Davies GR, Church CD, Reue K., Free PMC Article | 04/3/2021 |
| A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface. | A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.
Gabrovsek L, Collins KB, Aggarwal S, Saunders LM, Lau HT, Suh D, Sancak Y, Trapnell C, Ong SE, Smith FD, Scott JD., Free PMC Article | 01/16/2021 |
| depletion of dAKAP1-PKA "signaling islands" from the outer mitochondrial membrane augments progression toward metastatic breast cancer | Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.
Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD., Free PMC Article | 05/11/2019 |
| AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. | Mitochondrial AKAP1 supports mTOR pathway and tumor growth.
Rinaldi L, Sepe M, Delle Donne R, Conte K, Arcella A, Borzacchiello D, Amente S, De Vita F, Porpora M, Garbi C, Oliva MA, Procaccini C, Faicchia D, Matarese G, Zito Marino F, Rocco G, Pignatiello S, Franco R, Insabato L, Majello B, Feliciello A., Free PMC Article | 03/10/2018 |
| Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. [review] | Pivotal role of AKAP121 in mitochondrial physiology.
Czachor A, Failla A, Lockey R, Kolliputi N., Free PMC Article | 05/27/2017 |
| Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 in mitochondrial respiration. | Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.
Hoffman NJ, Parker BL, Chaudhuri R, Fisher-Wellman KH, Kleinert M, Humphrey SJ, Yang P, Holliday M, Trefely S, Fazakerley DJ, Stöckli J, Burchfield JG, Jensen TE, Jothi R, Kiens B, Wojtaszewski JF, Richter EA, James DE., Free PMC Article | 09/10/2016 |
| AKAP 149-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line | Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes.
Fernández-Araujo A, Tobío A, Alfonso A, Botana LM. | 04/4/2015 |
| In the case of the beta2AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta2AR complex. | A macromolecular trafficking complex composed of β₂-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels.
Flynn R, Altier C. | 01/4/2014 |
| AKAP1 anchors Star mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis. | Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis.
Grozdanov PN, Stocco DM., Free PMC Article | 06/22/2013 |
| In tumoural lymphocytes, yessotoxin decreases AKAP149 cytosolic expression and increases cAMP levels which leads to cell death. | Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins.
Tobío A, Fernández-Araujo A, Alfonso A, Botana LM. | 03/9/2013 |
| Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. | Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.
Burmeister BT, Taglieri DM, Wang L, Carnegie GK., Free PMC Article | 03/2/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. | 09/15/2010 |
| Protein phosphatase 1 binding occurs through a conserved RVXF motif found in the KH domain of AKAP149. | Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.
Rogne M, Stokka AJ, Taskén K, Collas P, Küntziger T. | 01/21/2010 |
| Results suggest that the interaction between reverse transcriptase and AKAP149 in infected cells may play an important role in HIV-1 reverse transcription. | AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.
Lemay J, Maidou-Peindara P, Cancio R, Ennifar E, Coadou G, Maga G, Rain JC, Benarous R, Liu LX. | 01/21/2010 |
| both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C | cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2.
Islam A, Jones H, Hiroi T, Lam J, Zhang J, Moss J, Vaughan M, Levine SJ., Free PMC Article | 01/21/2010 |
| DAKAP1alpha overexpression induced regulatory (R) or catalytic (C) subunits of PKA to outer mitochondrial colocalization and showed similar regulation | Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. | 01/21/2010 |
| AKAP149-regulated PP1 activity at the NE during G1 is required to maintain nuclear integrity and cell survival. | AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase.
Steen RL, Beullens M, Landsverk HB, Bollen M, Collas P. | 01/21/2010 |
| AMY-1 interacts with this and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. | AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H. | 01/21/2010 |
| RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1 | A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.
Carlson CR, Ruppelt A, Taskén K. | 01/21/2010 |