| The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. | The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons.
Poobalasingam T, Bianco F, Oozeer F, Gordon-Weeks PR. | 02/12/2022 |
| These data are carefully evaluated in light of other recent findings herein regarding the role of drebrin in actin filament organization at the ES. | Drebrin and Spermatogenesis.
Chen H, Li MWM, Yan Cheng C., Free PMC Article | 12/2/2017 |
| In the adult brain, drebrin is mainly localized in dendritic spines, but in some nuclei, drebrin can be detected in neuronal somata as well as dendritic spines. The fact that the developmental changes in drebrin expression highly correlate in time with the sensitive period of visual cortical plasticity in kittens suggests that synaptic plasticity depends on drebrin. | Localization of Drebrin: Light Microscopy Study.
Shirao T, Koganezawa N, Yamazaki H, Hanamura K, Imamura K. | 12/2/2017 |
| Data suggest that the myosin-II mediated drebrin A-actin exodus might be an initial event in chemical long-term potentiation (LTP) induction, triggering actin polymerization and spine enlargement. | Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.
Mizui T, Sekino Y, Yamazaki H, Ishizuka Y, Takahashi H, Kojima N, Kojima M, Shirao T., Free PMC Article | 12/6/2014 |
| Collectively, these results suggest that Dbn1 may play a key role in mouse brain development and may regulate NSC differentiation by filamentous actin. | Expression of Dbn1 during mouse brain development and neural stem cell differentiation.
Ao X, Liu Y, Qin M, Li C, Chen X, Xiao L, Liu J. | 07/26/2014 |
| A novel mechanism by which PTEN is required to maintain DBN phosphorylation at dynamic range. | Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ., Free PMC Article | 04/19/2014 |
| These findings show that drebrin contains a cryptic F-actin-bundling activity regulated by phosphorylation and provide a mechanistic model for microtubule-F-actin coupling. | Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation.
Worth DC, Daly CN, Geraldo S, Oozeer F, Gordon-Weeks PR., Free PMC Article | 11/2/2013 |
| our results indicate that in vivo drebrin A is not critical for spinogenesis and morphogenesis but instead is consistent with an involvement in synaptic structural integrity, stabilization, and function. | Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells.
Sbai O, Khrestchatisky M, Esclapez M, Ferhat L. | 07/28/2012 |
| Drebrin E plays a role in axonal growth through actin-myosin interactions in the transitional zone of axonal growth cones in primary hippocampal neuronal cultures. | Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions.
Mizui T, Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T. | 01/21/2010 |
| drebrin A modulates glutamatergic and GABAergic synaptic activities | Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons.
Ivanov A, Esclapez M, Pellegrino C, Shirao T, Ferhat L. | 01/21/2010 |
| Drebrin targets EB3 to coordinate F-actin-microtubule interactions that underlie neuritogenesis. | Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis.
Geraldo S, Khanzada UK, Parsons M, Chilton JK, Gordon-Weeks PR. | 01/21/2010 |
| Together these data demonstrate a novel mechanism in which the balance between stability and plasticity in dendritic spines depends on binding of drebrin to actin filaments in a manner that is regulated by Ras. | Interactions between drebrin and Ras regulate dendritic spine plasticity.
Biou V, Brinkhaus H, Malenka RC, Matus A. | 01/21/2010 |
| The disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblasts. | Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration.
Song M, Kojima N, Hanamura K, Sekino Y, Inoue HK, Mikuni M, Shirao T. | 01/21/2010 |
| Glutamate stimulation induced disappearance of drebrin immunostaining from dendritic spines but led to appearance of drebrin immunostaining in dendritic shafts and somata. | Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts.
Sekino Y, Tanaka S, Hanamura K, Yamazaki H, Sasagawa Y, Xue Y, Hayashi K, Shirao T. | 01/21/2010 |
| drebrin A accumulates spine-resident proteins via protein-protein interaction in filopodia, and suggest that the spine formation requires the concurrence of the increase of drebrin-A expression and the functional presynaptic contact | Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions.
Mizui T, Takahashi H, Sekino Y, Shirao T. | 01/21/2010 |
| These results demonstrate that drebrin A accumulates spine-resident proteins via protein-protein interaction in filopodia, and suggest that the spine formation requires the increase of drebrin-A expression and the functional presynaptic contact. | Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions.
Mizui T, Takahashi H, Sekino Y, Shirao T. | 01/21/2010 |
| drebrin-A may affect spine dynamics, vesicle transport, and other myosin-V-driven motility in neurons through attenuating the interaction between actin and myosin-V | Drebrin attenuates the interaction between actin and myosin-V.
Ishikawa R, Katoh K, Takahashi A, Xie C, Oseki K, Watanabe M, Igarashi M, Nakamura A, Kohama K. | 01/21/2010 |