| Role of CAMK2D in neurodevelopment and associated conditions. | Role of CAMK2D in neurodevelopment and associated conditions.
Rigter PMF, de Konink C, Dunn MJ, Proietti Onori M, Humberson JB, Thomas M, Barnes C, Prada CE, Weaver KN, Ryan TD, Caluseriu O, Conway J, Calamaro E, Fong CT, Wuyts W, Meuwissen M, Hordijk E, Jonkers CN, Anderson L, Yuseinova B, Polonia S, Beysen D, Stark Z, Savva E, Poulton C, McKenzie F, Bhoj E, Bupp CP, Bézieau S, Mercier S, Blevins A, Wentzensen IM, Xia F, Rosenfeld JA, Hsieh TC, Krawitz PM, Elbracht M, Veenma DCM, Schulman H, Stratton MM, Küry S, van Woerden GM., | 02/14/2024 |
| CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. | CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.
Chuah YH, Tay EXY, Grinchuk OV, Yoon J, Feng J, Kannan S, Robert M, Jakhar R, Liang Y, Lee BWL, Wang LC, Lim YT, Zhao T, Sobota RM, Lu G, Low BC, Crasta KC, Verma CS, Lin Z, Ong DST., Free PMC Article | 08/10/2023 |
| TRPM1 promotes tumor progression in acral melanoma by activating the Ca[2+]/CaMKIIdelta/AKT pathway. | TRPM1 promotes tumor progression in acral melanoma by activating the Ca(2+)/CaMKIIδ/AKT pathway.
Hsieh CC, Su YC, Jiang KY, Ito T, Li TW, Kaku-Ito Y, Cheng ST, Chen LT, Hwang DY, Shen CH., Free PMC Article | 02/11/2023 |
| miR-145-5p affects autophagy by targeting CaMKIIdelta in atherosclerosis. | miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
Zhang X, Zai L, Tao Z, Wu D, Lin M, Wan J. | 06/18/2022 |
| Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury. | Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury.
Tian T, Yao D, Zheng L, Zhou Z, Duan Y, Liu B, Wang P, Li Y., Free PMC Article | 04/13/2021 |
| This study provides new evidence supporting direct interaction between CaMKIIdelta and IKKbeta in pro-inflammatory signalling in cardiac fibroblasts and could represent a feature that may be exploited for therapeutic benefit. | CaMKIIδ interacts directly with IKKβ and modulates NF-κB signalling in adult cardiac fibroblasts.
Martin TP, McCluskey C, Cunningham MR, Beattie J, Paul A, Currie S. | 11/30/2019 |
| JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias. | Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.
Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X., Free PMC Article | 08/3/2019 |
| CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle. | Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases.
Lee KY, Chen YH, Hsu SC, Yu MJ., Free PMC Article | 06/24/2017 |
| TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1. | Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.
Mukherjee S, Sheng W, Sun R, Janssen LJ. | 06/24/2017 |
| CEACAM1 is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 and CaMK2D, and the same kinase enables lumen formation by CEACAM1 | Induction of Lumen Formation in a Three-dimensional Model of Mammary Morphogenesis by Transcriptional Regulator ID4: ROLE OF CaMK2D IN THE EPIGENETIC REGULATION OF ID4 GENE EXPRESSION.
Nguyen T, Shively JE., Free PMC Article | 05/6/2017 |
| CaMKIId activity is up-regulated in the myocardium of diabetic patients and mouse models of diabetes, where it promotes pathological signaling that includes hypertrophy, fibrosis and apoptosis. | The role of CaMKII in diabetic heart dysfunction.
Daniels L, Bell JR, Delbridge LM, McDonald FJ, Lamberts RR, Erickson JR. | 05/14/2016 |
| Study found a significant association with disordered gambling and rs167771 (DRD3) and with rs381572 (CAMK2D) in humans | Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models.
Lobo DS, Aleksandrova L, Knight J, Casey DM, el-Guebaly N, Nobrega JN, Kennedy JL. | 04/30/2016 |
| This study showed that AKAP12,CAMK2D and a molecular pathway(cyclic amp)association to outcome of depressive during citalopram treatment. | A molecular pathway analysis of the glutamatergic-monoaminergic interplay serves to investigate the number of depressive records during citalopram treatment.
Drago A, Cocchi E, Crisafulli C, Serretti A. | 11/14/2015 |
| Reveal a novel in vivo function of CaMKIIdelta in regulating H3 phosphorylation and suggest a novel epigenetic mechanism by which CaMKIIdelta controls cardiac hypertrophy. | Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress.
Awad S, Al-Haffar KM, Marashly Q, Quijada P, Kunhi M, Al-Yacoub N, Wade FS, Mohammed SF, Al-Dayel F, Sutherland G, Assiri A, Sussman M, Bers D, Al-Habeeb W, Poizat C., Free PMC Article | 04/18/2015 |
| CaMKIID specifically phosphorylates Thr-457 on CEACAM1-SF, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells. | Phosphorylation of CEACAM1 molecule by calmodulin kinase IID in a three-dimensional model of mammary gland lumen formation.
Nguyen T, Chen CJ, Shively JE., Free PMC Article | 04/12/2014 |
| CAMKIIdelta is required for PP1gamma-exacerbated apoptosis of cardiomyocytes. | PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.
Huang C, Cao W, Liao R, Wang J, Wang Y, Tong L, Chen X, Zhu W, Zhang W. | 03/15/2014 |
| Our studies suggest that CaMKII is a molecular signal that couples increased reactive oxygen species with atrial fibrillation and that therapeutic strategies to decrease oxidized CaMKII may prevent or reduce it. | Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME., Free PMC Article | 02/1/2014 |
| End-stage failing human hearts had more phosphorylation at CaMKII-dependent titin sites, contributing to their mechanical dysfunction & establishing a new role for CaMKIIdelta in regulating diastolic passive properties of healthy & diseased hearts. | Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.
Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Krüger M, Backs J, Linke WA. | 04/20/2013 |
| suggest that CaMKII and calcineurin provide a switch-like mechanism that controls Ca-dependent LIMK1, SSH1L and cofilin activation, and subsequently actin cytoskeletal reorganization | Regulation of cofilin activity by CaMKII and calcineurin.
Zhao JW, Gao ZL, Ji QY, Wang H, Zhang HY, Yang YD, Xing FJ, Meng LJ, Wang Y. | 02/16/2013 |
| Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation. | PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.
Mouton-Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, Herault Y, Verney C, Créau N. | 11/19/2011 |
| Single nucleotide polymorphism in CAMK2D gene is associated with epithelial ovarian cancer. | Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Permuth-Wey J, Chen YA, Tsai YY, Chen Z, Qu X, Lancaster JM, Stockwell H, Dagne G, Iversen E, Risch H, Barnholtz-Sloan J, Cunningham JM, Vierkant RA, Fridley BL, Sutphen R, McLaughlin J, Narod SA, Goode EL, Schildkraut JM, Fenstermacher D, Phelan CM, Sellers TA., Free PMC Article | 10/1/2011 |
| This study shows for the first time that CAMKII inhibition acutely improves contractility in human heart failure where CAMKIIdelta expression is increased. | Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium.
Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS. | 11/27/2010 |
| The crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, is described. | Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S., Free PMC Article | 10/30/2010 |
| Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA is involved in thrombin-induced endothelial barrier dysfunction | Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction.
Wang Z, Ginnan R, Abdullaev IF, Trebak M, Vincent PA, Singer HA., Free PMC Article | 08/16/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |