| AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. | AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, Lahiri SK, Wehrens XHT, McConnell BK., Free PMC Article | 05/1/2024 |
| Loss of AKAP12 aggravates rheumatoid arthritis-like symptoms and cardiac damage in collagen-induced arthritis mice. | Loss of AKAP12 aggravates rheumatoid arthritis-like symptoms and cardiac damage in collagen-induced arthritis mice.
Ni Y, Cao J, Yuan J, Ning X., Free PMC Article | 05/19/2023 |
| Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. | Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models.
Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E., Free PMC Article | 10/15/2022 |
| AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway. | AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway.
Wu X, Luo Y, Wang S, Li Y, Bao M, Shang Y, Chen L, Liu W., Free PMC Article | 06/18/2022 |
| Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. | Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum.
Takase H, Hamanaka G, Ohtomo R, Park JH, Chung KK, Gelman IH, Kim KW, Lok J, Lo EH, Arai K., Free PMC Article | 03/5/2022 |
| Downregulation of microRNA-144 inhibits proliferation and promotes the apoptosis of myelodysplastic syndrome cells through the activation of the AKAP12-dependent ERK1/2 signaling pathway. | Downregulation of microRNA-144 inhibits proliferation and promotes the apoptosis of myelodysplastic syndrome cells through the activation of the AKAP12-dependent ERK1/2 signaling pathway.
Qian W, Jin F, Zhao Y, Chen Y, Ge L, Liu L, Yang M. | 06/12/2021 |
| AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. | AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke.
Seo JH, Maki T, Miyamoto N, Choi YK, Chung KK, Hamanaka G, Park JH, Mandeville ET, Takase H, Hayakawa K, Lok J, Gelman IH, Kim KW, Lo EH, Arai K., Free PMC Article | 03/6/2021 |
| This study demonstrates that AKAP12-mediated regulation of portal fibroblasts and liver sinusoidal endothelial cells has a central role in resolving hepatic fibrosis. | Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution.
Lee HS, Choi J, Son T, Wee HJ, Bae SJ, Seo JH, Park JH, Ryu SH, Lee D, Jang MK, Yu E, Chung YH, Kim KW., Free PMC Article | 04/25/2020 |
| The absence of gravin-mediated signaling lowers blood pressure, reduces plaque formation in the aorta, and decreases lipid accumulation and damage in the liver of mice, fed a high fat diet. | Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis.
Fan Q, Yin X, Rababa'h A, Diaz Diaz A, Wijaya CS, Singh S, Suryavanshi SV, Vo HH, Saeed M, Zhang Y, McConnell BK., Free PMC Article | 04/11/2020 |
| suggest that AKAP12 signaling in pericytes may be required for oligodendrocyte precursor cells-to-oligodendrocyte renewal to maintain the white matter homeostasis in adult brain | A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter.
Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K., Free PMC Article | 04/20/2019 |
| fibrosis induced by Ang II may be alleviated by AKAP12 expression through inactivation of the TGF-beta1 pathway. | Blockage of AKAP12 accelerates angiotensin II (Ang II)-induced cardiac injury in mice by regulating the transforming growth factor β1 (TGF-β1) pathway.
Li Y, Yu QH, Chu Y, Wu WM, Song JX, Zhu XB, Wang Q. | 10/13/2018 |
| gravin is an important component of cardiac contraction | Force development and intracellular Ca(2+) in intact cardiac muscles from gravin mutant mice.
Li Z, Singh S, Suryavanshi SV, Ding W, Shen X, Wijaya CS, Gao WD, McConnell BK., Free PMC Article | 12/9/2017 |
| The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. | Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.
Ko HK, Guo LW, Su B, Gao L, Gelman IH., Free PMC Article | 12/26/2015 |
| AKAP12 scaffolding protein mediates meningeal reconstruction after central nervous system injury | Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury.
Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Lee OH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW., Free PMC Article | 12/19/2015 |
| Results suggest that AKAP12-positive cells in the fibrotic scar may restrict excessive inflammation, demonstrating mechanisms that could underlie the beneficial actions of the fibrotic scar in the new tissue formation stage during the CNS repair process. | AKAP12 mediates barrier functions of fibrotic scars during CNS repair.
Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Kim EH, Lee OH, Heo JH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW., Free PMC Article | 01/10/2015 |
| Disruption of gravin's scaffold mediated signaling is able to increase baseline cardiac function as well as to augment contractility in response to acute beta-AR stimulation. | Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade.
Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK., Free PMC Article | 06/21/2014 |
| We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced beta2-adrenergic receptor signaling and ERK activation in the hippocampus | Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.
Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T., Free PMC Article | 03/2/2013 |
| Our study implicates a role for SSeCKS in preventing of skin cancer progression possibly through negatively regulating FAK expression. | Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation.
Akakura S, Bouchard R, Bshara W, Morrison C, Gelman IH., Free PMC Article | 09/15/2012 |
| controls the localization and activity of cyclin D1 in parietal epithelial cells and influences proliferative injury in the glomerulus | SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.
Burnworth B, Pippin J, Karna P, Akakura S, Krofft R, Zhang G, Hudkins K, Alpers CE, Smith K, Shankland SJ, Gelman IH, Nelson PJ. | 05/26/2012 |
| PKC-mediated remodeling of the actin cytoskeleton is likely regulated by the ability of SSeCKS to control PKC signaling and activity through a direct scaffolding function | Control of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12.
Guo LW, Gao L, Rothschild J, Su B, Gelman IH., Free PMC Article | 01/14/2012 |
| Akap12 controls Rb-mediated cell aging and oncogenic progression by directly scaffolding and attenuating PKCalpha/delta. | Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.
Akakura S, Nochajski P, Gao L, Sotomayor P, Matsui S, Gelman IH., Free PMC Article | 04/16/2011 |
| SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma | SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma.
Mardin WA, Petrov KO, Enns A, Senninger N, Haier J, Mees ST., Free PMC Article | 03/26/2011 |
| SSeCKS-null mice have increased susceptibility for oncogenic transformation in the prostate. | Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia.
Akakura S, Huang C, Nelson PJ, Foster B, Gelman IH., Free PMC Article | 01/21/2010 |
| v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. | v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex.
Bu Y, Gelman IH. | 01/21/2010 |
| Phosphorylation of SSeCKS by mitogenically activated kinases decreases intrinsic cell scaffolding activities and suggests that SSeCKS regulatory functions are lost in the late G1 phase. | Calmodulin and cyclin D anchoring sites on the Src-suppressed C kinase substrate, SSeCKS.
Lin X, Gelman IH. | 01/21/2010 |