| MicroRNA-329-3p inhibits the Wnt/beta-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1. | MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1.
Sun H, Kawano M, Iwasaki T, Itonaga I, Kubota Y, Tsumura H, Tanaka K., Free PMC Article | 03/21/2024 |
| TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells. | TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells.
King CM, Marx OM, Ding W, Koltun WA, Yochum GS., Free PMC Article | 03/3/2023 |
| [T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis]. | [T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis].
Feng W, Liu Y, Chen J, Qiao C, Xia L, Wu K. | 01/29/2022 |
| TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population. | TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population.
Chen J, Xu Y, Hu H, Jin T., Free PMC Article | 05/29/2021 |
| Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies. | Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.
Mayer CD, Giclais SM, Alsehly F, Hoppler S., Free PMC Article | 03/20/2021 |
| Results provide some new insights into how extracellular signals modulate the self-renewal of liver CSCs and highlight the inhibitory roles of Tcf7l1 in cancer. | Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.
Shan J, Shen J, Wu M, Zhou H, Feng J, Yao C, Yang Z, Ma Q, Luo Y, Wang Y, Qian C. | 07/18/2020 |
| High TCF7L1 expression is associated with non-seminomatous testicular germ cell tumors. | Wnt suppressor and stem cell regulator TCF7L1 is a sensitive immunohistochemical marker to differentiate testicular seminoma from non-seminomatous germ cell tumor.
Bu L, Yang Q, McMahon L, Xiao GQ, Li F. | 02/29/2020 |
| Data indicate that transcription factor transcription factor 7-like 1 (TCF7L1) could regulate antioxidant response in gastric cancer cells by regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway. | TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y., Free PMC Article | 08/10/2019 |
| HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. | Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.
Hikasa H, Sokol SY., Free PMC Article | 07/13/2018 |
| Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. | Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells.
Chiaro C, Lazarova DL, Bordonaro M. | 07/13/2018 |
| Our results identify TCF3 as a central regulator of tumor growth and initiation. | Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3.
Slyper M, Shahar A, Bar-Ziv A, Granit RZ, Hamburger T, Maly B, Peretz T, Ben-Porath I. | 07/13/2018 |
| TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. | TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments.
Liu W, Liu Y, Guo T, Hu C, Luo H, Zhang L, Shi S, Cai T, Ding Y, Jin Y., Free PMC Article | 07/13/2018 |
| TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. | Molecular functions of the TLE tetramerization domain in Wnt target gene repression.
Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI., Free PMC Article | 07/13/2018 |
| These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. | A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.
Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS., Free PMC Article | 07/13/2018 |
| TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth | TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3.
Murphy M, Chatterjee SS, Jain S, Katari M, DasGupta R., Free PMC Article | 06/2/2018 |
| TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation | TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency.
Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan PJ., Free PMC Article | 04/7/2018 |
| Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. | TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.
Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H., Free PMC Article | 02/17/2018 |
| report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects | Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP., Free PMC Article | 08/20/2016 |
| Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. | Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, Gerhauser C. | 04/13/2013 |
| No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. | TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.
Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK. | 09/27/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T., Free PMC Article | 04/8/2009 |