| Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia. | Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia.
Vila È, Pinacho R, Prades R, Tarragó T, Castro E, Munarriz-Cuezva E, Meana JJ, Eugui-Anta A, Roldan M, Vera-Montecinos A, Ramos B., Free PMC Article | 04/15/2023 |
| Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain. | Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain.
Shirenova SD, Khlebnikova NN, Krupina NA. | 07/17/2021 |
| In mitotic phases, PREP shares its localization with tubulin in Sertoli cells, gonocytes, and spermatogonia. | Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm.
Venditti M, Minucci S., Free PMC Article | 02/29/2020 |
| The data indicated the involvement of genes associated with the serotoninergic system in the mechanisms of mental disorders induced by post-weaning social isolation and suggest the gene encoding prolyl endopeptidase as a candidate gene involved in the pathogenesis of these disorders. | Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures.
Zubkov EA, Zorkina YA, Orshanskaya EV, Khlebnikova NN, Krupina NA, Chekhonin VP. | 06/1/2019 |
| Frontal cortex prolyl endopeptidase levels are reduced following benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine treatment in a rat model of depressive syndrome. | Effect of prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in brain structures of rats with experimental MPTP-induced depressive syndrome.
Khlebnikova NN, Krupina NA, Bogdanova NG, Zolotov NN. | 07/26/2014 |
| PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin. | Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.
Jalkanen AJ, Savolainen K, Forsberg MM. | 06/9/2012 |
| Data show that enzymatic activity of prolyl oligopeptidase (POP) is highest on embryonic day 18 while the protein amounts reach their peak at birth, and support a role for POP in neurogenesis. | Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain.
Hannula MJ, Männistö PT, Myöhänen TT. | 07/16/2011 |
| Overall, the present data support the possibility that PEP exerts specific functions related to neurodevelopment besides those proposed to date. | Prolyl endopeptidase mRNA expression in the central nervous system during rat development.
Agirregoitia N, Bizet P, Agirregoitia E, Boutelet I, Peralta L, Vaudry H, Jégou S. | 08/16/2010 |
| localization of POP in thalamocortical & corticothalamic projection neurons in ventrobasal complex & medial geniculate nucleus of thalamus & somatosensory/motor & auditory cortices; in thalamus & cortex over 50% of projection neurons contained POP | Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.
Myöhänen TT, Kääriäinen TM, Jalkanen AJ, Piltonen M, Männistö PT. | 01/21/2010 |
| Results describe the distribution of immunoreactive prolyl oligopeptidase in human and rat brain. | Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.
Myöhänen TT, Venäläinen JI, Tupala E, Garcia-Horsman JA, Miettinen R, Männistö PT. | 01/21/2010 |
| PTZ-induced seizures of the rats activate glutamate NMDA receptors, then decrease prolyl oligopeptidase enzyme activity in hippocampal neurons. | Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.
Ahmed MM, Arif M, Chikuma T, Kato T. | 01/21/2010 |
| Prolyl oligopeptidase is the main enzyme responsible for synthesis of the antifibrotic peptide Ac-SDKP. | Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.
Cavasin MA, Rhaleb NE, Yang XP, Carretero OA., Free PMC Article | 01/21/2010 |
| Prolyl endopeptidase is actually involved in the inactivation of regulatory neuropeptides. | Localization of the mRNA encoding prolyl endopeptidase in the rat brain and pituitary.
Bellemère G, Vaudry H, Mounien L, Boutelet I, Jégou S. | 01/21/2010 |
| The regional distribution of Prep in rat brain was more homogeneous than in humans, and higher than in peripheral tissues. | Distribution of prolyl endopeptidase activities in rat and human brain.
Irazusta J, Larrinaga G, González-Maeso J, Gil J, Meana JJ, Casis L. | 01/21/2010 |