| FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2. | FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2.
Tsutsumi K, Nohara A, Tanaka T, Murano M, Miyagaki Y, Ohta Y., Free PMC Article | 01/16/2024 |
| ARHGAP24 represses beta-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. | ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.
Yang W, Wang B, Yu Q, Liu T, Li T, Tian T, Jin A, Ding L, Chen W, Wang H, Xian J, Pan B, Zhou J, Fan J, Yang X, Guo W., Free PMC Article | 10/8/2022 |
| FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM. | FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
Saito K, Mori M, Kambara N, Ohta Y. | 07/17/2021 |
| ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis. | ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.
Wang L, Shen S, Xiao H, Ding F, Wang M, Li G, Hu F., Free PMC Article | 10/31/2020 |
| AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion. | AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion.
Tsutsumi K, Nakamura Y, Kitagawa Y, Suzuki Y, Shibagaki Y, Hattori S, Ohta Y. | 09/5/2020 |
| study showed that HOTAIRM1 suppressed ovarian cancer progression through derepression of ARHGAP24 by sponging miR-106a-5p | HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p.
Chao H, Zhang M, Hou H, Zhang Z, Li N. | 04/4/2020 |
| Results showed that ARHGAP24 expression was downregulated in lung cancer tissues and cell lines. | Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating β-Catenin Signaling.
Wang L, Shen S, Wang M, Ding F, Xiao H, Li G, Hu F., Free PMC Article | 03/9/2019 |
| ARHGAP24 can suppress the development of MDA-MB-231 cells via the STAT3 signaling pathway, and sorafenib inhibits cell viability, migration, invasion, and STAT3 activation in MDA-MB-231 cells through ARHGAP24. | Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
Dai X, Geng F, Dai J, Li M, Liu M., Free PMC Article | 02/2/2019 |
| MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24 | MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24.
Wang L, Wei WQ, Wu ZY, Wang GC. | 07/7/2018 |
| ARHGAP24 plays a unique role in renal cell carcinoma progression as a tumor repressor. | ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.
Xu G, Lu X, Huang T, Fan J., Free PMC Article | 02/10/2018 |
| this study clearly provided evidence that FilGAP, as well as IDH1 status, may be useful for predicting the behavior of astrocytomas. In addition, the FilGAP/Rac1 axis may serve as an important regulator of tumor progression in GBMs, probably through alteration of cell morphology. | The role of FilGAP, a Rac-specific Rho-GTPase-activating protein, in tumor progression and behavior of astrocytomas.
Hara A, Hashimura M, Tsutsumi K, Akiya M, Inukai M, Ohta Y, Saegusa M., Free PMC Article | 11/18/2017 |
| ARHGAP24 may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells. | Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Uehara S, Saito K, Asami H, Ohta Y. | 09/23/2017 |
| Study identified FilGAP as a negative regulator of lymphocyte polarization and migration and shows that FilGAP may suppress lamellae formation at the front of migrating lymphocyte. | The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration.
Iida T, Saito K, Katagiri K, Kinashi T, Ohta Y. | 05/13/2017 |
| Src family tyrosine kinase signaling may regulate FilGAP through association with RBM10 | Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10.
Yamada H, Tsutsumi K, Nakazawa Y, Shibagaki Y, Hattori S, Ohta Y., Free PMC Article | 07/30/2016 |
| FilGAP may contribute to change in cell motility of B-lymphocytes and in addition, its expression appears to be useful for predicting the behavior of B-cell lymphoma, in particular follicular lymphoma. | FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.
Nishi T, Takahashi H, Hashimura M, Yoshida T, Ohta Y, Saegusa M., Free PMC Article | 03/5/2016 |
| study suggests that Arf6 and phosphorylation of FilGAP may regulate FilGAP, and phosphorylation of Ser-402 may play a role in the regulation of cell spreading on fibronectin | Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein.
Morishita Y, Tsutsumi K, Ohta Y., Free PMC Article | 02/20/2016 |
| Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants. | Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in Han Chinese population.
Liu L, Yao J, Li J, Zhang J, Yu J, Jiang X, Sun S, Liu Q, Chang Y, He Y, Lin J. | 09/13/2014 |
| FilGAP may function as a mediator of the regulation of Rac by Arf6. | ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.
Kawaguchi K, Saito K, Asami H, Ohta Y., Free PMC Article | 05/31/2014 |
| Data indicate that phosphorylation of FilGAP by ROCK appears to promote amoeboid morphology. | FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.
Saito K, Ozawa Y, Hibino K, Ohta Y., Free PMC Article | 06/8/2013 |
| Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction | Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP., Free PMC Article | 01/28/2012 |
| sequencing of the ARHGAP24 gene in patients with focal segmental glomerulosclerosis (FSGS) identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS | Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Gbadegesin R, Antignac C, Pollak M, Kopp JB, Winn MP, Shaw AS., Free PMC Article | 11/26/2011 |
| Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.
Horinouchi M, Yagi M, Imanishi H, Mori T, Yanai T, Hayakawa A, Takeshima Y, Hijioka M, Okamura N, Sakaeda T, Matsuo M, Okumura K, Nakamura T. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Several common variants modulate heart rate, PR interval and QRS duration.
Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, Stefansdottir H, Gudjonsson SA, Jonasdottir A, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Løchen ML, Kong A, Thorsteinsdottir U, Stefansson K. | 01/20/2010 |
| FilGAP plays a role in protecting cells against force-induced apoptosis. | The role of FilGAP-filamin A interactions in mechanoprotection.
Shifrin Y, Arora PD, Ohta Y, Calderwood DA, McCulloch CA., Free PMC Article | 01/21/2010 |