| Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture. | Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture.
Long S, Liu Z, Wang Y. | 04/3/2024 |
| Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells. | Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells.
Aguilera AC, Leiva N, Alvarez PA, Pulcini G, Pereyra LL, Morales CR, Sosa MÁ, Carvelli L., Free PMC Article | 03/7/2023 |
| Sortilin regulates blood-brain barrier integrity. | Sortilin regulates blood-brain barrier integrity.
Toth AE, Helms HC, Harazin A, Johnsen KB, Goldeman C, Burkhart A, Thomsen MS, Kempen PJ, Klepe A, Lipka DV, Møller PL, Andresen TL, Nyegaard M, Moos T, Brodin B, Nielsen MS. | 03/5/2022 |
| A luciferase reporter assay confirmed that SORT1 is the direct target of miR-182. Our study suggests that SORT1 plays a vital role in the development of arterial calcification and is regulated by miR-182. | The miR-182/SORT1 axis regulates vascular smooth muscle cell calcification in vitro and in vivo.
Zhang Z, Jiang W, Yang H, Lin Q, Qin X. | 10/6/2018 |
| Data suggest that sortilin expression in both gastrocnemius and extensor digitorum longus muscle is down-regulated by 17-18h of fasting/food deprivation; pathological levels of high blood glucose, as in streptozotocin-induced diabetes, do not alter sortilin expression in skeletal muscle; sortilin expression is elevated during differentiation of myocyte cell line or in presence of high concentration of glucose. | Glucose deprivation attenuates sortilin levels in skeletal muscle cells.
Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi SI. | 10/7/2017 |
| Reduced sortilin levels associate with lower VLDL apo B secretion. Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. | Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells.
Sparks RP, Guida WC, Sowden MP, Jenkins JL, Starr ML, Fratti RA, Sparks CE, Sparks JD., Free PMC Article | 05/27/2017 |
| Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1. | Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
Lu C, Zhu W, Shen CL, Gao W., Free PMC Article | 02/14/2015 |
| sortilin expression characterizes human atheromatous lesions and rat aortic post-injury neointima, and suggest that sortilin represents an important regulator of proNGF-induced SMC apoptosis and arterial remodeling. | Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells.
Campagnolo L, Costanza G, Francesconi A, Arcuri G, Moscatelli I, Orlandi A., Free PMC Article | 09/20/2014 |
| the regulation of sortilin shedding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway or to the lysosome, thus modulating the bioavailability of endogenous BDNF. | Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, Blobel C, Hempstead BL., Free PMC Article | 10/22/2011 |
| Results suggest that proneurotrophin-3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex. | Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.
Tauris J, Gustafsen C, Christensen EI, Jansen P, Nykjaer A, Nyengaard JR, Teng KK, Schwarz E, Ovesen T, Madsen P, Petersen CM., Free PMC Article | 06/4/2011 |
| Macrophages in vivo (ED1+) and isolated in vitro (CD11b+) express moderate levels of proBDNF, sortilin and p75NTR after spinal cord injry. | ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury.
Wong I, Liao H, Bai X, Zaknic A, Zhong J, Guan Y, Li HY, Wang YJ, Zhou XF. | 09/27/2010 |
| expression pattern of sortilin did not change in ischemic state induced by elevated intraocular pressure | Immunohistochemical localization of sortilin and p75(NTR) in normal and ischemic rat retina.
Xu F, Wei Y, Lu Q, Zheng D, Zhang F, Gao E, Wang N. | 01/21/2010 |
| These results suggested that the protein expressions of 60 and 50 kDa forms of p75(NTR), and the 90 kDa mature form of sortilin increased in ischemia-induced retinal neuron of rats. | Enhanced protein expressions of sortilin and p75NTR in retina of rat following elevated intraocular pressure-induced retinal ischemia.
Wei Y, Wang N, Lu Q, Zhang N, Zheng D, Li J. | 01/21/2010 |
| Expression of p75 and sortilin increased in FN SCs distal (P < .05) to the axotomy compared with the contralateral controls for all time points, which correlates with increased apoptosis. | p75NTR and sortilin increase after facial nerve injury.
Provenzano MJ, Xu N, Ver Meer MR, Clark JJ, Hansen MR. | 01/21/2010 |
| first comprehensive description of the distribution of NTS3/sortilin mRNA and protein in adult rat brain using in situ hybridization and immunocytochemistry | Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system.
Sarret P, Krzywkowski P, Segal L, Nielsen MS, Petersen CM, Mazella J, Stroh T, Beaudet A. | 01/21/2010 |