| ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder. | ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder.
Przyklenk M, Karmacharya S, Bonasera D, Pasanen-Zentz AL, Kmoch S, Paulsson M, Wagener R, Liccardi G, Schiavinato A., Free PMC Article | 05/14/2024 |
| Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway. | Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway.
Zhou C, Liang A, Zhang J, Leng J, Xi B, Zhou B, Yang Y, Zhu R, Zhong L, Jiang X, Wan D., | 12/15/2023 |
| Two siblings with GAPO syndrome: Ophthalmic presentation and histopathologic findings. | Two siblings with GAPO syndrome: Ophthalmic presentation and histopathologic findings.
Falcone MM, Chang YH, Lidov H, Stagner AM, Dagi LR. | 11/22/2023 |
| ANTXR1 Regulates Erythroid Cell Proliferation and Differentiation through wnt/beta-Catenin Signaling Pathway In Vitro and in Hematopoietic Stem Cell. | ANTXR1 Regulates Erythroid Cell Proliferation and Differentiation through wnt/β-Catenin Signaling Pathway In Vitro and in Hematopoietic Stem Cell.
Jin T, Zhang Z, Han Y, Li D, Liu J, Jiang M, Kurita R, Nakamura Y, Hu F, Fang X, Huang S, Sun Z., Free PMC Article | 09/10/2022 |
| Transmembrane Protein ANTXR1 Regulates gamma-Globin Expression by Targeting the Wnt/beta-Catenin Signaling Pathway. | Transmembrane Protein ANTXR1 Regulates γ-Globin Expression by Targeting the Wnt/β-Catenin Signaling Pathway.
Jin T, Zhang Z, Han Y, Li D, Liu J, Jiang M, Zhu J, Kurita R, Nakamura Y, Hu F, Xu Y, Fang X, Huang S, Sun Z., Free PMC Article | 08/20/2022 |
| Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression. | Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression.
Bu X, Chen Z, Zhang A, Zhou X, Zhang X, Yuan H, Zhang Y, Yin C, Yan Y. | 02/12/2022 |
| N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8. | N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.
Li M, Fang L, Kwantwi LB, He G, Luo W, Yang L, Huang Y, Yin S, Cai Y, Ma W, Zhan H, Tong Z, Zhang L, Liang C, Yin Y., Free PMC Article | 01/22/2022 |
| N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection. | N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection.
Jayawardena N, Miles LA, Burga LN, Rudin C, Wolf M, Poirier JT, Bostina M., Free PMC Article | 12/18/2021 |
| Targeted silencing of TEM8 suppresses nonsmall cell lung cancer tumor growth via the ERK/Bcl2 signaling pathway. | Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway.
Gong Q, Deng J, Zhang L, Zhou C, Fu C, Wang X, Zhuang L., Free PMC Article | 11/22/2021 |
| Overexpression of tumor endothelial marker 8 protein predicts poor prognosis in angiosarcoma. | Overexpression of tumor endothelial marker 8 protein predicts poor prognosis in angiosarcoma.
Kusaba Y, Kajihara I, Sakamoto R, Maeda-Otsuka S, Yamada-Kanazawa S, Sawamura S, Makino K, Aoi J, Masuguchi S, Fukushima S. | 10/9/2021 |
| TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer. | TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.
Xu J, Yang X, Deng Q, Yang C, Wang D, Jiang G, Yao X, He X, Ding J, Qiang J, Tu J, Zhang R, Lei QY, Shao ZM, Bian X, Hu R, Zhang L, Liu S., Free PMC Article | 07/31/2021 |
| inspection showed that MSLN (Mesothelin), ANTXR1 (TEM8), and MUC3A are the probable targets of CAR T cell therapy in gastric adenocarcinoma. | MSLN (Mesothelin), ANTXR1 (TEM8), and MUC3A are the potent antigenic targets for CAR T cell therapy of gastric adenocarcinoma.
Sotoudeh M, Shirvani SI, Merat S, Ahmadbeigi N, Naderi M. | 06/20/2020 |
| our findings suggested that ANTXR1 plays a crucial role in the development and progression of gastric cancer (GC) and could serve as a novel prognostic biomarker and potential therapeutic target for GC. | Anthrax toxin receptor 1/tumor endothelial marker 8 promotes gastric cancer progression through activation of the PI3K/AKT/mTOR signaling pathway.
Cai C, Dang W, Liu S, Huang L, Li Y, Li G, Yan S, Jiang C, Song X, Hu Y, Gu J., Free PMC Article | 04/25/2020 |
| Our results reinforce the clinical characteristics of the syndrome, expand the mutational spectrum and provide more insights into the role of the ANTXR1 protein in the regulation of extracellular matrix. | GAPO syndrome in seven new patients: Identification of five novel ANTXR1 mutations including the first large intragenic deletion.
Abdel-Hamid MS, Ismail S, Zaki MS, Abdel-Salam GMH, Otaify GA, Issa MY, Abdel-Kader M, Girgis M, Aboul-Ezz E, Mazen I, Aglan MS, Temtamy SA. | 02/8/2020 |
| The frequency of the CC genotype of rs4527238 was observed to be high in the low HbF patient group compared to the high HbF group. | ANTXR1 Intronic Variants Are Associated with Fetal Hemoglobin in the Arab-Indian Haplotype of Sickle Cell Disease.
Al-Ali ZA, Fallatah RK, Aljaffer EA, Albukhari ER, Sadek Al-Ali N, Al-Ghannam ZT, Sayeb Al-Atrash R, Alsuliman A, Vatte C. | 06/15/2019 |
| Consistent with experimental study, computational results indicate the metal ion in TEM8 contributes significantly to the binding affinity, and anthrax protective antigen-TEM8 binding is more favorable in the presence of Mg(2+) than Ca(2+) . | Effects from metal ion in tumor endothelial marker 8 and anthrax protective antigen: BioLayer Interferometry experiment and molecular dynamics simulation study.
Jia Z, Ackroyd C, Han T, Agrawal V, Liu Y, Christensen K, Dominy B. | 05/18/2019 |
| TEM8 is a novel receptor for uPA | TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.
Zhang LC, Shao Y, Gao LH, Liu J, Xi YY, Xu Y, Wu C, Chen W, Chen HP, Wang YL, Duan HF, Hu XW., Free PMC Article | 05/11/2019 |
| Our findings implicate ANTXR1 as a candidate gene for isolated TA, suggest the involvement of specific hypomorphic alleles, and expand the previously known ANTXR1-associated phenotypes. | A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis.
Dinckan N, Du R, Akdemir ZC, Bayram Y, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM, Guven Y, Aktoren O, Kayserili H, Boerwinkle E, Gibbs RA, Posey JE, Lupski JR, Uyguner ZO, Letra A., Free PMC Article | 03/2/2019 |
| Results demonstrate that the capsid footprint on the receptor is not conserved in anthrax toxin receptor 2 (ANTXR2), thereby providing a molecular mechanism for explaining the exquisite selectivity of SVV for ANTXR1. | Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus.
Jayawardena N, Burga LN, Easingwood RA, Takizawa Y, Wolf M, Bostina M., Free PMC Article | 01/26/2019 |
| Silencing TEM8 may inhibit proliferation of XWLC05 lung cancer cells, promote cell apoptosis, arrest the cell cycle at G1 phase and decrease the migration and invasive ability. | Effect of silencing TEM8 gene on proliferation, apoptosis, migration and invasion of XWLC‑05 lung cancer cells.
Gong Q, Liu C, Wang C, Zhuang L, Zhang L, Wang X., Free PMC Article | 07/14/2018 |
| Novel targets ANTXR1 and RSPO2 were confirmed to be suppressed by miR-493 directly. | MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2).
Xu Y, Ge K, Lu J, Huang J, Wei W, Huang Q. | 04/28/2018 |
| These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for Seneca Valley virus. | Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus.
Miles LA, Burga LN, Gardner EE, Bostina M, Poirier JT, Rudin CM., Free PMC Article | 10/14/2017 |
| expression does not affect cytotoxicity to anthrax toxin | ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells.
Fujikura D, Toyomane K, Kamiya K, Mutoh M, Mifune E, Ohnuma M, Higashi H., Free PMC Article | 06/24/2017 |
| Findings suggest that down-regulation of tumor endothelial marker 8 play an important role in the inhibition of tumorigenesis and development of osteosarcoma. | Down-regulation of tumor endothelial marker 8 suppresses cell proliferation mediated by ERK1/2 activity.
Cao C, Wang Z, Huang L, Bai L, Wang Y, Liang Y, Dou C, Wang L., Free PMC Article | 01/14/2017 |
| TEM8 may be differentially expressed between wound types and loss of this molecule impacts HaCaT growth and migration, potentially implicating this molecule as a factor involved in successful progression of wound healing. | Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes.
Wang SC, Ye L, Sanders AJ, Ruge F, Harding KG, Jiang WG., Free PMC Article | 10/29/2016 |