| A chloride channel in rat pancreatic acinar AR42J cells is sensitive to extracellular acidification and dependent on ROS. | A chloride channel in rat pancreatic acinar AR42J cells is sensitive to extracellular acidification and dependent on ROS.
Yang X, Zhao C, Mahdy SA, Xu P, Yu M, Wu J, Wang L, Jacob TJ, Zhu L, Peng S, Deng Z, Chen L, Wang L. | 12/5/2020 |
| Data suggest that the chloride channel-3 (CLC-3) might be modulated by transforming growth factor beta (TGF-beta) / TGF-beta Receptor II (TGF- beta RII) signaling pathway during the development of diabetic encephalopathy (DE). | TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.
Fan F, Qi J, Liu N, Wang Z, Wang W, Liu H, Xu X, Chen G, Wang X, Yang H, Johnson M, Tu Y, Liu T, Fu J. | 04/6/2019 |
| Knockdown of CLC-3 in hippocampal CA1 significantly attenuates the contextual fear memory, reduces spine density, induces defects of excitatory synaptic ultrastructure showed by the decreased PSD length, PSD thickness and active zone length, and impairs L-LTP induction and maintenance, and induces the synaptic NMDAR subunit composition to an increased GluN2A/GluN2B ratio pattern and reduces the activity of CaMKII-alpha. | Knockdown of CLC-3 in the hippocampal CA1 impairs contextual fear memory.
Chen YF, Chen ZX, Wang RH, Shi YW, Xue L, Wang XG, Zhao H. | 03/30/2019 |
| Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo. | Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract.
Ji L, Cheng L, Yang Z., Free PMC Article | 09/29/2018 |
| Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy. | ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy.
Li C, Huang D, Tang J, Chen M, Lu Q, Li H, Zhang M, Xu B, Mao J. | 12/30/2017 |
| Data suggest that ClC3/Clcn3 expression is up-regulated by mechanical stimulation (persistent static compression here) in osteoblastic cell line and appears to participate in mechanically sensitive osteogenesis and gene expression regulation. | ClC-3 chloride channel functions as a mechanically sensitive channel in osteoblasts.
Wang H, Wang R, Wang Z, Liu Q, Mao Y, Duan X. | 09/17/2016 |
| Integrin beta3 mediates cerebrovascular remodelling during hypertension via Src/ClC-3 signalling pathway. | Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl(-) channel signalling pathway.
Zeng JW, Wang XG, Ma MM, Lv XF, Liu J, Zhou JG, Guan YY., Free PMC Article | 01/24/2015 |
| Tyrosine 284 phosphorylation in the ClC-3 channel targeted by Src kinase is an important molecular mechanism for ClC-3 channel activation. | Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells.
Wang XG, Tao J, Ma MM, Tang YB, Zhou JG, Guan YY. | 01/4/2014 |
| Data suggest that Clcn3 activity and chloride ion movement due to hypotonic solution are more prominent in smooth muscle cell from femoral artery than from femoral vein; regulation of Clcn3 activity via tyrosine phosphorylation is prominent in veins. | Differences between femoral artery and vein smooth muscle cells in volume-regulated chloride channels.
Kang XL, Zhang M, Liu J, Lv XF, Tang YB, Guan YY. | 05/4/2013 |
| Our results demonstrated for the first time that rat bone marrow endothelial progenitor cells expressed volume-sensitive chloride currents and the corresponding gene and protein Clcn3. | Intermediate-conductance Ca(2+) -activated potassium and volume-sensitive chloride channels in endothelial progenitor cells from rat bone marrow mononuclear cells.
Xu X, Xia J, Yang X, Huang X, Gao D, Zhou J, Lian J, Zhou J. | 09/15/2012 |
| ClC-3 has protective effects on H2O2-induced apoptosis of basilar artery smooth muscle cells through influencing the mitochondrial signaling pathway. | ClC-3 chloride channel prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through mitochondria dependent pathway.
Qian Y, Du YH, Tang YB, Lv XF, Liu J, Zhou JG, Guan YY. | 08/20/2011 |
| ClC-3 mRNA and protein expression levels were significantly higher in aortic smooth muscle and brain tissues of diabetic rats, but significantly decreased in kidney medulla tissue, relative to non-DM controls | Expression patterns of ClC-3 mRNA and protein in aortic smooth muscle, kidney and brain in diabetic rats.
Fu J, Fu J, Gao B, Wang L, Zhang N, Li X, Ji Q. | 09/13/2010 |
| Downregulation of ClC-3 channel with ClC-3 antisense transfection reduced static pressure-evoked cell proliferation and cell cycle transition. | Static pressure promotes rat aortic smooth muscle cell proliferation via upregulation of volume-regulated chloride channel.
Qian JS, Pang RP, Zhu KS, Liu DY, Li ZR, Deng CY, Wang SM. | 02/22/2010 |
| The present study was to investigate the role of ClC-3 in cell cycle progression/distribution and the underlying mechanisms of proliferation. | Silence of ClC-3 chloride channel inhibits cell proliferation and the cell cycle via G/S phase arrest in rat basilar arterial smooth muscle cells.
Tang YB, Liu YJ, Zhou JG, Wang GL, Qiu QY, Guan YY., Free PMC Article | 01/21/2010 |
| PAF induces intracellular acidosis via activation of the Ca(2+)-dependent Cl(-) channel ClC-3, resulting in apoptosis of intestinal epithelial cells. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.
Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, Nelson DJ, Marks J, Jilling T., Free PMC Article | 01/21/2010 |
| Upregulation of ClC-3 is an adaptive response of inflamed pulmonary artery, which enhances the viability of pulmonary artery smooth muscle cells against reactive oxygen species. | ClC-3 chloride channel is upregulated by hypertrophy and inflammation in rat and canine pulmonary artery.
Dai YP, Bongalon S, Hatton WJ, Hume JR, Yamboliev IA., Free PMC Article | 01/21/2010 |
| ClC-3 is strongly expressed in the apical membrane of the caput epididymidis and the vas deferens and is less abundant in cells of the body and cauda epididymidis. | Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM.
Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S. | 01/21/2010 |
| By increasing postsynaptic potentials in a Cl(-) dependent fashion, CLC-3 channels regulate neuronal excitability postsynaptically in immature neurons. | CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons.
Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ. | 01/21/2010 |