| NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins. | NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
Ma Y, Huang X, Wang Y, Lei Y, Yu J, Yu S, Gao Y, Yang J, Zhao F, Yu H, Zeng J, Chu Y, Yang M, Li G, Xie X, Zhang J., Free PMC Article | 03/7/2024 |
| The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer. | The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D., Free PMC Article | 02/22/2024 |
| Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA., Free PMC Article | 05/3/2023 |
| A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. | A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
Campos Gudiño R, Farrell AC, Neudorf NM, McManus KJ., Free PMC Article | 02/5/2022 |
| microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/beta-catenin signaling pathway. | microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway.
Liang K, Liao L, Liu Q, Ouyang Q, Jia L, Wu G. | 01/15/2022 |
| Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer. | Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
Lepage CC, Palmer MCL, Farrell AC, Neudorf NM, Lichtensztejn Z, Nachtigal MW, McManus KJ., Free PMC Article | 12/18/2021 |
| [Effects of Cullin1 on the Biological Characteristics of Lung AdenocarcinomaA549 and H1395 Cells]. | [Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma
A549 and H1395 Cells].
Liu J, Su S, He H, Wang H, Zhang D., Free PMC Article | 10/2/2021 |
| Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. | Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
Kim SO, Cho KS, Kim BY, Lee KH., Free PMC Article | 08/21/2021 |
| Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation. | Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
Sun X, Tong X, Hao Y, Li C, Zhang Y, Pan Y, Dai Y, Liu L, Zhang T, Zhang S., Free PMC Article | 07/17/2021 |
| CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease. | CUL1-Mediated Organelle Fission Pathway Inhibits the Development of Chronic Obstructive Pulmonary Disease.
Li R, Xu F, Wu X, Ji S, Xia R., Free PMC Article | 05/1/2021 |
| CUL1 Knockdown Attenuates the Adhesion, Invasion, and Migration of Triple-Negative Breast Cancer Cells via Inhibition of Epithelial-Mesenchymal Transition. | CUL1 Knockdown Attenuates the Adhesion, Invasion, and Migration of Triple-Negative Breast Cancer Cells via Inhibition of Epithelial-Mesenchymal Transition.
Ren ZQ, Yan WJ, Zhang XZ, Zhang PB, Zhang C, Chen SK. | 04/3/2021 |
| The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes. | The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes.
Sweeney MA, Iakova P, Maneix L, Shih FY, Cho HE, Sahin E, Catic A., Free PMC Article | 01/9/2021 |
| Does single gene expression omnibus data mining analysis apply for only tumors and not mental illness? A preliminary study on bipolar disorder based on bioinformatics methodology. | Does single gene expression omnibus data mining analysis apply for only tumors and not mental illness? A preliminary study on bipolar disorder based on bioinformatics methodology.
You X, Zhang Y, Long Q, Liu Z, Feng Z, Zhang W, Teng Z, Zeng Y., Free PMC Article | 09/19/2020 |
| CUL1 disassociates from NLRP3 to release the repression of the NLRP3 inflammasome. | Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation.
Wan P, Zhang Q, Liu W, Jia Y, Ai S, Wang T, Wang W, Pan P, Yang G, Xiang Q, Huang S, Yang Q, Zhang W, Liu F, Tan Q, Zhang W, Wu K, Liu Y, Wu J. | 05/16/2020 |
| UL1 regulated EZH2 expression to promote the production of cytokines, and finally significantly aggravating the breast cancer cell metastasis and angiogenesis through the PI3K-AKT-mTOR signaling pathway. | CUL1 promotes breast cancer metastasis through regulating EZH2-induced the autocrine expression of the cytokines CXCL8 and IL11.
Huang YF, Zhang Z, Zhang M, Chen YS, Song J, Hou PF, Yong HM, Zheng JN, Bai J., Free PMC Article | 11/16/2019 |
| High expression of CUL1 is associated with colorectal cancer. | Synergistic role of Cul1 and c-Myc: Prognostic and predictive biomarkers in colorectal cancer.
Wang W, Deng J, Wang Q, Yao Q, Chen W, Tan Y, Ge Z, Zhou J, Zhou Y. | 05/19/2018 |
| we analyzed eight probands with clinically suspected Weaver syndrome by whole-exome sequencing and identified three mutations: a 25.4-kb deletion partially involving EZH2 and CUL1 ,a missense mutation , and a missense mutation in SUZ12 inherited from her father .In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased decreased trimethylation of lysine 27 of H3 | Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.
Imagawa E, Higashimoto K, Sakai Y, Numakura C, Okamoto N, Matsunaga S, Ryo A, Sato Y, Sanefuji M, Ihara K, Takada Y, Nishimura G, Saitsu H, Mizuguchi T, Miyatake S, Nakashima M, Miyake N, Soejima H, Matsumoto N. | 02/24/2018 |
| DCUN1D3 has a role in activating SCFSKP2 ubiquitin E3 ligase activity through cullin-1 neddylation and cell cycle progression in tumor cells with UV damage | DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.
Zhang S, Huang J, Shi T, Hu F, Zhang L, Zhou PK, Ma D, Ma T, Qiu X., Free PMC Article | 02/24/2018 |
| Cullin1 and MMP-2 expressions could be novel diagnostic and prognostic markers for colorectal cancer patients. | Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer.
Deng J, Chen W, Du Y, Wang W, Zhang G, Tang Y, Qian Z, Xu P, Cao Z, Zhou Y. | 02/24/2018 |
| Our results demonstrate that increased CUL1 expression is significantly correlated with poor prognosis of patients with osteosarcoma. CUL1 might be an important marker and a therapeutic target for osteosarcoma. | Cullin-1 regulates MG63 cell proliferation and metastasis and is a novel prognostic marker of osteosarcoma.
Cheng Q, Yin G. | 02/24/2018 |
| Our results demonstrate that increased CUL1 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma | Expression of CUL1 correlates with tumour-grade and recurrence in urothelial carcinoma.
Mao SY, Xiong DB, Huang TB, Zheng JH, Yao XD. | 02/24/2018 |
| unneddylated Cul1 is another central player involved in maintenance of the adaptor module pool through the formation of Cul1-Skp-1-F-box complexes and promotion of rapid SCF assembly | Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly.
Liu Q, Zhou Y, Tang R, Wang X, Hu Q, Wang Y, He Q., Free PMC Article | 12/2/2017 |
| Data suggest that cullin1 (Cul1) may constitute a potential therapeutic target in renal cell carcinoma (RCC). | The expression of Cullin1 is increased in renal cell carcinoma and promotes cancer cell proliferation, migration, and invasion.
Ping JG, Wang F, Pu JX, Hou PF, Chen YS, Bai J, Zheng JN. | 02/25/2017 |
| Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR. eIF4F suppression inhibited the promoting effect of Cul1 on melanoma cell proliferation. | Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
Chen L, Liu T, Tu Y, Rong D, Cao Y. | 10/22/2016 |
| Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells. | Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.
Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y, Yin Y., Free PMC Article | 10/1/2016 |