| Genetically programmed changes in transcription of the novel progranulin regulator. | Genetically programmed changes in transcription of the novel progranulin regulator.
Keller M, Gebhardt C, Huth S, Schleinitz D, Heyne H, Scholz M, Stumvoll M, Böttcher Y, Tönjes A, Kovacs P., Free PMC Article | 10/9/2021 |
| Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population. | Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.
Rodríguez-Arellano ME, Solares-Tlapechco J, Costa-Urrutia P, Cárdenas-Hernández H, Vallejo-Gómez M, Granados J, Salas-Padilla S., Free PMC Article | 04/3/2021 |
| Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length. | Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
Nehlig A, Seiler C, Steblyanko Y, Dingli F, Arras G, Loew D, Welburn J, Prigent C, Barisic M, Nahmias C., Free PMC Article | 03/6/2021 |
| the frequency of SNP rs599839 located in the 3' UTR of the PSRC1 gene in patients with genetically confirmed diagnosis of heterozygous familial hypercholesterolemia was analyzed. It was found that there was no association between rs599839 alleles and coronary heart disease in the multivariate analysis. | Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients.
Sánchez Muñoz-Torrero JF, Rivas MD, Zamorano J, Joya-Vázquez PP, de Isla LP, Padro T, Mata P, The Safeheart Investigators. | 01/5/2019 |
| Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle. | DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.
Kwon HJ, Park JE, Song H, Jang CY. | 08/5/2017 |
| these data indicate that ASB7 plays a crucial role in regulating spindle dynamics and genome integrity by controlling the expression of DDA3. | ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T., Free PMC Article | 06/3/2017 |
| no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of coronary artery disease or ischemic stroke | Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.
Zhou YJ, Hong SC, Yang Q, Yin RX, Cao XL, Chen WX., Free PMC Article | 10/22/2016 |
| Thus, ANKRD53 is recruited to the mitotic spindle by DDA3 and acts as a regulator of spindle dynamics and cytokinesis. | ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis.
Kim S, Jang CY. | 06/28/2016 |
| Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 and Ska1. | Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore.
Park JE, Song H, Kwon HJ, Jang CY. | 06/28/2016 |
| DDA3 controls astral spindle formation and spindle positioning by targeting Cep290 to the centrosome. Depletion of Cep290 caused a reduction of the astral spindle, leading to misorientation of the mitotic spindle. | DDA3 targets Cep290 into the centrosome to regulate spindle positioning.
Song H, Park JE, Jang CY. | 08/29/2015 |
| PSRC1 in the cholesterol gene cluster shows a significant association with coronary artery disease and its single nucleotide polymorphism regulates plasma cholesterol levels. | CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort.
Arvind P, Nair J, Jambunathan S, Kakkar VV, Shanker J. | 05/30/2015 |
| Thus, the EB1-based function of DDA3 links MT dynamics to directional cell migration | DDA3 associates with microtubule plus ends and orchestrates microtubule dynamics and directional cell migration.
Zhang L, Shao H, Zhu T, Xia P, Wang Z, Liu L, Yan M, Hill DL, Fang G, Chen Z, Wang D, Yao X., Free PMC Article | 10/19/2013 |
| kinases control the function of DDA3 in the cell cycle by regulating its microtubules-polymerizing/bundling activities through sequential phosphorylation. | Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3.
Jang CY, Coppinger JA, Yates JR 3rd, Fang G., Free PMC Article | 07/23/2011 |
| MCAK and CENP-E are involved in DDA3-mediated chromosome congression. | DDA3 associates with MCAK and controls chromosome congression.
Jang CY, Fang G. | 07/16/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Additive effect of multiple genetic variants on the risk of coronary artery disease.
Lluís-Ganella C, Lucas G, Subirana I, Sentí M, Jimenez-Conde J, Marrugat J, Tomás M, Elosua R. | 12/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.
Ma L, Yang J, Runesha HB, Tanaka T, Ferrucci L, Bandinelli S, Da Y., Free PMC Article | 06/30/2010 |
| the mitotic function of DDA3 is regulated by phosphorylation on the Ser225 residue. | Phospho-regulation of DDA3 function in mitosis.
Jang CY, Coppinger JA, Yates JR 3rd, Fang G., Free PMC Article | 03/22/2010 |
| The C-terminal domain confers its ability to associate with the mitotic spindle, while the regulatory N-terminal domain controls the microtubule-binding by the C-terminal domain and determines the cellular activity of the DDA3 protein. | The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3.
Jang CY, Fang G. | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J. | 09/16/2009 |
| The novel CAD-associated locus in the vicinity of the PSRC1 and CELSR2 genes on chromosome 1 probably enhances CAD risk through an effect on plasma LDL cholesterol. | The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol.
Samani NJ, Braund PS, Erdmann J, Götz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M, Hengstenberg C, Stark K, Ziegler A, Caulfield M, Burton PR, Schunkert H, Tobin MD. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (14) articlesA multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki ML, Nieminen MS, Melander O, Salomaa V, Peltonen L, Kathiresan S. Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans.
Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, Berg D, Schulte C, Khan N, Tatagiba M, Krischek B. Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.
Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.
Keebler ME, Deo RC, Surti A, Konieczkowski D, Guiducci C, Burtt N, Buxbaum SG, Sarpong DF, Steffes MW, Wilson JG, Taylor HA, Kathiresan S. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.
Reynolds CA, Hong MG, Eriksson UK, Blennow K, Wiklund F, Johansson B, Malmberg B, Berg S, Alexeyenko A, Grönberg H, Gatz M, Pedersen NL, Prince JA. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.
Keebler ME, Sanders CL, Surti A, Guiducci C, Burtt NP, Kathiresan S. Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.
Bressler J, Folsom AR, Couper DJ, Volcik KA, Boerwinkle E. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, Wang J. Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.
Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S, Jichi Community Genetics Team (JCOG). Genetic analysis of coronary artery disease single-nucleotide polymorphisms in diabetic nephropathy.
McKnight AJ, Maxwell AP, Fogarty DG, Sadlier D, Savage DA, Warren 3/UK GoKinD Study Group. Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
Lanktree MB, Anand SS, Yusuf S, Hegele RA, SHARE Investigators. [Association of single nucleotide polymorphism rs599839 on chromosome 1p13.3 with premature coronary heart disease in a Chinese Han population].
Huang H, Pan L, Zhang L, Chen Y, Zeng Z. | 01/11/2009 |
| Together these results identify ASPP2 as a bona fide DDA3 interacting protein, and suggest that the ASPP2/DDA3 interaction may inhibit ASPP2 in stimulating the apoptotic signaling of p53. | p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation.
Sun WT, Hsieh PC, Chiang ML, Wang MC, Wang FF. | 01/21/2010 |
| DDA3 represents a new class of microtubule-destabilizing protein that controls spindle dynamics and mitotic progression by regulating microtubule depolymerases. | DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement.
Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G., Free PMC Article | 01/21/2010 |
| Together our results show that hDDA3 is a p53- and DNA-damage down-regulated target that exhibits oncogenic characteristics. | Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage.
Hsieh WJ, Hsieh SC, Chen CC, Wang FF. | 01/21/2010 |