| site-directed mutagenesis the role of three key residues (K4, E225, R229) involved in salt bridges stabilizing the lid domain that controls the access to the active site and is part of the interfacial recognition site. Their substitution has an impact on the pH-dependent activity of rHGL and its relative activities on medium and long chain triglycerides. | Constitutive expression of human gastric lipase in Pichia pastoris and site-directed mutagenesis of key lid-stabilizing residues.
Sams L, Amara S, Chakroun A, Coudre S, Paume J, Giallo J, Carrière F. | 11/25/2017 |
| LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis | Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer.
Kong Y, Zheng Y, Jia Y, Li P, Wang Y., Free PMC Article | 03/18/2017 |
| In patients with intrahepatic cholestasis of pregnancy, there was no elevation in LIPF mRNA in maternal circulation compared with controls. | Intrahepatic Cholestasis of Pregnancy: mRNAs for LIPF and ELOVL4 Genes Are Not Detectable in Circulating Maternal Plasma.
Zucchini C, Montesanto I, Falcone V, Azzaroli F, Pittalis MC, Farina A. | 09/10/2016 |
| Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system. | Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system.
Vardakou M, Sainsbury F, Rigby N, Mulholland F, Lomonossoff GP. | 03/3/2012 |
| insights into the domain movements | Molecular dynamics simulations of human and dog gastric lipases: insights into domain movements.
Selvan A, Seniya C, Chandrasekaran SN, Siddharth N, Anishetty S, Pennathur G. | 01/1/2011 |
| down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer | An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.
Zhang X, Yang JJ, Kim YS, Kim KY, Ahn WS, Yang S. | 03/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesA common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).
Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 12/2/2009 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S. | 03/25/2009 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes.
Srivastava V, Deshpande SN, Nimgaonkar VL, Lerer B, Thelma B. | 08/20/2008 |
| identidfied the cap and the lid residues involved in the binding with the lipidic substrate | Importance of the lid and cap domains for the catalytic activity of gastric lipases.
Miled N, Bussetta C, De caro A, Rivière M, Berti L, Canaan S. | 01/21/2010 |
| Mechanisms of inhibition of triacylglycerol hydrolysis | Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase.
Pafumi Y, Lairon D, de la Porte PL, Juhel C, Storch J, Hamosh M, Armand M. | 01/21/2010 |