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    GCN5 histone acetyltransferase GCN5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853167, updated on 7-Jul-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    the Ada2 SANT domain does not activate Gcn5's activity by directly affecting histone peptide binding as previously proposed. Instead, the Ada2 SANT domain enhances Gcn5 binding of the enzymatic cosubstrate acetyl-CoA.

    Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
    Sun J, Paduch M, Kim SA, Kramer RM, Barrios AF, Lu V, Luke J, Usatyuk S, Kossiakoff AA, Tan S., Free PMC Article

    This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation.

    Chromatin dynamics during DNA replication.
    Bar-Ziv R, Voichek Y, Barkai N.,

    It conserved Spt-Ada-Gcn5 acetyltransferase (SAGA) complex as a paradigm to illustrate how co-activators share and combine a relatively limited set of functional tools.

    Sharing the SAGA.
    Helmlinger D, Tora L., Free PMC Article

    Gcn5 acetyltransferase synergizes with Spt3 (TBP-binding) to promote transcription.

    SAGA Is a General Cofactor for RNA Polymerase II Transcription.
    Baptista T, Grünberg S, Minoungou N, Koster MJE, Timmers HTM, Hahn S, Devys D, Tora L., Free PMC Article

    In this study it has been demonstrated for the first time that Gcn5 and SAGA are needed for respiratory metabolism and oxygen consumption.

    SAGA complex and Gcn5 are necessary for respiration in budding yeast.
    Canzonetta C, Leo M, Guarino SR, Montanari A, Francisci S, Filetici P.

    Gcn5 is required for activation of nuclear genes and lifespan extension in the retrograde response.These results, along with the finding that the histone deacetylase Sir2 was required for a robust retrograde response informed a bioinformatics screen that reduced to four the candidate genes causal for longevity .Of the four, only deletion of PHO84 suppressed lifespan extension

    Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae.
    Jiang JC, Stumpferl SW, Tiwari A, Qin Q, Rodriguez-Quiñones JF, Jazwinski SM., Free PMC Article

    We find that RTS1, one of two genes encoding PP2A regulatory subunits, is a robust and specific high-copy suppressor of temperature sensitivity of gcn5 and a subset of other gcn5 phenotypes

    Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.
    Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L., Free PMC Article

    e describe here our observation of both full length and a truncated form of a yeast protein (Gcn5) expressed in Escherichia coli, and the reduction or elimination of the truncated form by mutating a cryptic Shine-Dalgarno or START codon within the Gcn5 coding region.

    Elimination of truncated recombinant protein expressed in Escherichia coli by removing cryptic translation initiation site.
    Jennings MJ, Barrios AF, Tan S., Free PMC Article

    Gcn5, Snf2, and Ydj1 cooperate in eviction of promoter nucleosomes genome-wide, achieving robust transcription of the most highly expressed subset of genes in yeast.

    Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.
    Qiu H, Chereji RV, Hu C, Cole HA, Rawal Y, Clark DJ, Hinnebusch AG., Free PMC Article

    Gcn5 plays an important role in the regulatory network of FLO11 expression via Gcn4 by downregulating ICR1 expression, which derepresses FLO11 for promoting pseudohyphal development

    The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae.
    Wang LC, Montalvo-Munoz F, Tsai YC, Liang CY, Chang CC, Lo WS., Free PMC Article

    The 3D structure of SAGA complexes in which the subunit Sgf73 is partially or fully deleted to remove the deubiquitination module revealed the module localized in the vicinity of Gcn5 and Spt7.

    Mapping the deubiquitination module within the SAGA complex.
    Durand A, Bonnet J, Fournier M, Chavant V, Schultz P.

    the Gcn5 bromodomain contributes to lysine specificity and is necessary for processive acetylation on histone H3.

    The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
    Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, Taverna SD., Free PMC Article

    Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1

    Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1.
    Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP., Free PMC Article

    NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.

    SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases.
    Bennett G, Peterson CL., Free PMC Article

    Gcn5-dependent H3K36 acetylation increases chromatin accessibility, increases resection and promotes homologous recombination DNA repair.

    A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.
    Pai CC, Deegan RS, Subramanian L, Gal C, Sarkar S, Blaikley EJ, Walker C, Hulme L, Bernhard E, Codlin S, Bähler J, Allshire R, Whitehall S, Humphrey TC., Free PMC Article

    data suggest a novel mechanism of regulation whereby Gcn5 functions to titrate the activity of Ifh1 following its recruitment to RP promoters to provide more than an all-or-nothing mode of transcriptional regulation

    Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1.
    Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP., Free PMC Article

    an alternative explanation for previously indicated repressive role of Gcn5 in gene transcription

    Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome.
    Xue-Franzén Y, Henriksson J, Bürglin TR, Wright AP., Free PMC Article

    we show that under derepressing conditions the recruitment of the histone acetyltransferase Gcn5 is abolished by SNF1 deletion, possibly explaining the lack of increased histone H3 acetylation and nucleosome remodelling

    Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter.
    Abate G, Bastonini E, Braun KA, Verdone L, Young ET, Caserta M., Free PMC Article

    Data support a model in which p23 molecular chaperone and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes.

    The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
    Zelin E, Zhang Y, Toogun OA, Zhong S, Freeman BC., Free PMC Article

    Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p.

    Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p.
    Mallory MJ, Law MJ, Sterner DE, Berger SL, Strich R., Free PMC Article

    SIR2 deletion extended maximum chronological lifespan in wine yeasts grown under laboratory conditions, but shortened it in winemaking. Deletions of sirtuin HST2 and acetyltransferase GCN5 had the opposite effect to SIR2 mutation in both media.

    Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium.
    Orozco H, Matallana E, Aranda A.

    We present our working model in which Elp3/Gcn5 and the APC work together to facilitate passage through mitosis and G(1). To progress into S, we propose that at least Gcn5 must then be targeted for degradation in an APC-dependent fashion.

    The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.
    Turner EL, Malo ME, Pisclevich MG, Dash MD, Davies GF, Arnason TG, Harkness TA., Free PMC Article

    Gcn5 regulates divergent sets of KCl responsive genes in S. cerevisiae and S. pombe.

    Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles.
    Xue-Franzén Y, Johnsson A, Brodin D, Henriksson J, Bürglin TR, Wright AP., Free PMC Article

    propose that GCN5 acts as a positive regulator of DNA replication by counteracting the inhibitory effect of Histone Deacetylases

    GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae.
    Espinosa MC, Rehman MA, Chisamore-Robert P, Jeffery D, Yankulov K., Free PMC Article

    Gcn5p is a target regulated by the competing actions of Snf1p and Spt3p.

    Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p.
    Liu Y, Xu X, Kuo MH., Free PMC Article

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