| A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC.DNA.Cdc6. | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Schmidt JM, Yang R, Kumar A, Hunker O, Seebacher J, Bleichert F., Free PMC Article | 04/23/2022 |
| Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. | Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Philip J, Örd M, Silva A, Singh S, Diffley JF, Remus D, Loog M, Ikui AE., Free PMC Article | 03/5/2022 |
| The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. | The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
Feng X, Noguchi Y, Barbon M, Stillman B, Speck C, Li H., Free PMC Article | 07/24/2021 |
| DNA replication origins retain mobile licensing proteins. | DNA replication origins retain mobile licensing proteins.
Sánchez H, McCluskey K, van Laar T, van Veen E, Asscher FM, Solano B, Diffley JFX, Dekker NH., Free PMC Article | 04/17/2021 |
| The global role of cyclin-specific phosphorylation has been resolved whereby a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin has been uncovered. | Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
Örd M, Venta R, Möll K, Valk E, Loog M., Free PMC Article | 01/18/2020 |
| Repression of CDC6 and SLD2 during meiosis coincides with expression of shortened isoforms. | Transcriptional repression of CDC6 and SLD2 during meiosis is associated with production of short heterogeneous RNA isoforms.
Phizicky DV, Bell SP., Free PMC Article | 07/6/2019 |
| Cdc6 degradation triggered by Mck1 kinase was enhanced upon DNA damage. | Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.
Al-Zain A, Schroeder L, Sheglov A, Ikui AE., Free PMC Article | 06/4/2016 |
| Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-replicative complex after helicase loading to advance subsequent steps in helicase activation in vivo. | Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.
Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M., Free PMC Article | 05/14/2016 |
| Data indicate that Cdt1-MCM2-7 complex activates ORC/Cdc6 ATP-hydrolysis to promote helicase loading. | An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.
Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C. | 08/31/2013 |
| We propose that both CDK and Mck1 kinases are required for Cdc6 degradation to ensure a tight control of DNA replication. | A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
Ikui AE, Rossio V, Schroeder L, Yoshida S., Free PMC Article | 05/11/2013 |
| Tom1 and the Dia2 control Cdc6 degradation in G1 phase. | The Hect domain E3 ligase Tom1 and the F-box protein Dia2 control Cdc6 degradation in G1 phase.
Kim DH, Zhang W, Koepp DM., Free PMC Article | 03/30/2013 |
| findings show that Mcm2-7 loading requires the coordinate action of the origin recognition complex and Cdc6 ATPases | Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Randell JC, Bowers JL, Rodríguez HK, Bell SP. | 01/21/2010 |
| Cdc6 protein is crucial for DNA replication | Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication.
Honey S, Futcher B., Free PMC Article | 01/21/2010 |
| Cdc6p delays a specific subset of mitotic events and that Cdc28 inhibition is not sufficient to account for it. The depletion of Cdc6p in G(2)/M cells reveals that Cdc6p is rate limiting for the degradation of the APC/Cdc20 substrates Pds1p and Clb2p. | Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55.
Boronat S, Campbell JL., Free PMC Article | 01/21/2010 |
| Cdc6 and origin DNA activate a molecular switch in Origin Recognition Complex that contributes to pre-RC assembly. | ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Speck C, Chen Z, Li H, Stillman B., Free PMC Article | 01/21/2010 |
| the mitotic CDK, Clb2/Cdc28, binds tightly to an amino-terminal domain of Cdc6, and Cdc6 in this complex is unable to assemble pre-replicative complexes | Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control.
Mimura S, Seki T, Tanaka S, Diffley JF. | 01/21/2010 |
| Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication | Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.
Speck C, Stillman B., Free PMC Article | 01/21/2010 |